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  1. Antihistamine
    AntihistamineDrugs that treat allergies
    OverviewCPT codeProcedureSide effectsOverdose
  2. Copilot Answer
    ATC codeR06
    Mechanism of action• Receptor antagonist · • Inverse agonist
    Biological targetHistamine receptors · • HRH1 · • HRH2 · • HRH3 · • HRH4
    Medical uses

    Histamine makes blood vessels more permeable (vascular permeability), causing fluid to escape from capillaries into tissues, which leads to the classic symptoms of an allergic reaction—a runny nose and watery eyes. Hista… See more

    Types

    H1-antihistamines refer to compounds that inhibit the activity of the H1 receptor. Since the H1 receptor exhibits constitutive activity, H1-antihistamines can be either neutral receptor antagonists or inverse agonists. Normally, h… See more

    Atypical antihistamines

    Inhibit the action of histidine decarboxylase:
    • Tritoqualine
    • Catechin
    Mast cell stabilizers are drugs which prevent mast cell degranulation. Examples include:
    • … See more

    History

    The first H1 receptor antagonists were discovered in the 1930s and were marketed in the 1940s. Piperoxan was discovered in 1933 and was the first compound with antihistamine effects to be identified. Piperoxan … See more

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