• Cate Blanchett as Lilith
• Kevin Hart as Roland Greaves
• Jack Black as the voice of Claptrap
• Edgar Ramírez as Deukalian Atlas
• Ariana Greenblatt as Tiny Tina
• Florian Munteanu as Krieg
• Gina Gershon as Mad Moxxi
• Jamie Lee Curtis as Patricia Tannis
• Haley Bennett as Lilith's mom
• Bobby Lee as Larry
• Olivier Richters as Krom
• Janina Gavankar as Commander Knoxx
• Benjamin Byron Davis as Marcus
• Harry Ford as Middleman
• Paula Andrea Placido as Quinn
• Steven Boyer as Scooter
• Ryann Redmond as Ellie
Additionally, Penn Jillette, who voiced Pain in the video game Borderlands 3 (2019), was going to have a cameo in the film as a preacher overseeing a wedding; this scene was cut from the final version. Scenes with Cheyenne Jackson as Wainwright Jakobs and Charles Babalola as Alistair Hammerlock were also cut.

In 2011, Gearbox Software CEO Randy Pitchford had his first conversation about a possible film adaptation of Borderlands with producers Avi and Ari Arad of Arad Productions. Pitchford was convinced that a film adaption would work after the release of Tales from the Borderlands. He later planned on starting a Borderlands cinematic universe. In May 2015, Leigh Whannell was in talks with Lionsgate to write and direct an adaptation of the video game series. The film was officially announced in August 2015; however, Whannell's involvement was left omitted.

Eli Roth stated that his French bulldog pooping gave him inspiration while pitching the film. "I have to look away because she gets really shy. But one day I filmed her. She had that shy look on her face and I was like, 'That's Claptrap.'" A scene of Claptrap pooping was included in the final film.

Aaron Berg was tapped to pen an R-rated take on the material in April 2016. By June 2018, Oren Uziel assumed scripting duties from Berg. On February 20, 2020, Lionsgate announced that Roth was attached to direct the film from a screenplay written by Craig Mazin, with Erik Feig joining as producer through his production company Picturestart. By April 2021, Mazin's script had been rewritten by Juel Taylor and Tony Rettenmaier; and again by Roth. A plot synopsis was released in April.

Cate Blanchett was cast as Lilith in May 2020. Speaking of her decision to join the project, Blanchett said: "The gun-slinging stuff was so much fun. I got really absorbed in that whole world. I think there also may have been a little Covid madness—I was spending a lot of time in the garden, using the chainsaw a little too freely. My husband said, 'This film could save your life'." Kevin Hart trained with United States Navy SEALs prior to auditioning for the role of Roland. The rest of the ensemble cast was announced between January and April 2021. Roth stated that he wanted to include cosplayers in the film as extras and kill them off.

Filming began on April 1, 2021, in Budapest, Hungary, during the COVID-19 pandemic, and wrapped on June 22. On June 4, 2021, first-look images of the cast were released, with black-and-white images obscuring all but the cast's silhouettes. In January 2023, it was announced the film would be going through two weeks of reshoots directed by Tim Miller, due to Roth's commitments to Thanksgiving. Zak Olkewicz wrote new pages for Miller. In June 2023, Mazin removed his name from the project, replaced by Joe Crombie; Mazin has denied reports that Crombie was his pseudonym. Additional literary material was credited to Berg, Uziel, Taylor, Rettenmaier, Olkewicz, Chris Bremner, and Sam Levinson. Steve Jablonsky compose…

Read more on Wikipedia

Borderlands was initially planned to be released in 2022. It premiered at the TCL Chinese Theatre in Los Angeles on August 6, 2024. It was theatrically released in the United States by Lionsgate Films on August 9, 2024. The film cost $110–120 million to produce, and Lionsgate spent $30 million on print and advertising. International pre-sales reportedly covered 60% of production costs. Sales of Borderlands 3 on Steam rose after the film's release and the concurrent player amount doubled from around 6,000 to a peak of 12,231.
On August 18, 2024, Lionsgate Home Entertainment announced that Borderlands would be released on Digital HD and platforms on August 30, 2024. The film was released on DVD, Blu-ray, and 4K Ultra HD Blu-ray on October 22, 2024.