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DNA repair - Wikipedia
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual … See more
Pathological effects of poor DNA repair
Experimental animals with genetic deficiencies in DNA repair often show decreased life span and increased cancer incidence. For example, mice deficient in the dominant NHEJ pathway and in telomere … See moreCells exposed to ionizing radiation, ultraviolet light or chemicals are prone to acquire multiple sites of bulky DNA lesions and double-strand breaks. Moreover, DNA damaging agents can damage other biomolecules such as proteins, carbohydrates See more
Hereditary DNA repair disorders
Defects in the NER mechanism are responsible for several genetic disorders, including:
• See moreDamage to DNA is very common and is constantly being repaired. Epigenetic alterations can accompany DNA repair of oxidative damage or double-strand breaks. In human cells, … See more
Wikipedia text under CC-BY-SA license Nucleotide excision repair - Wikipedia
Nucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize specific non-bulky lesions
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DNA damage (naturally occurring) - Wikipedia
WEBThe seven main types of DNA repair and one pathway of damage tolerance, the lesions they address, and the accuracy of the repair (or tolerance) are shown in this table. For a …
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DNA repair - Simple English Wikipedia, the free encyclopedia
WEBDNA repair means the processes by which a cell identifies and corrects damage to its DNA molecules. In cells, normal metabolic activities and environmental factors such as UV …
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Mechanisms of DNA damage, repair and mutagenesis
WEBAt least five major DNA repair pathways—base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), homologous recombination (HR) and non …
- Author: Nimrat Chatterjee, Graham C. Walker
- DOI: 10.1002/em.22087
- Publish Year: 2017
- Published: 2017/06
DNA Damage & Repair: Mechanisms for Maintaining DNA Integrity
WEBDefects in DNA repair underlie a number of human genetic diseases that affect a wide variety of body systems but share a constellation of common traits, most notably a …
DNA repair | Enzymes, Pathways & Benefits | Britannica
WEBDNA repair ensures the survival of a species by enabling parental DNA to be inherited as faithfully as possible by offspring. It also preserves the health of an individual. Mutations …
DNA damage repair - Nature
WEBFeb 13, 2023 · CRISPR-based genetic screens are providing new insights into the consequences of deficiencies in DNA damage response and repair pathways.
DNA damage repair: historical perspectives, mechanistic …
WEBJul 9, 2021 · In this review, we first illustrate the timeline steps for the understanding the roles of DNA damage repair in the promotion of cancer and cancer therapy developed, …
Exploring DNA Damage and Repair Mechanisms: A Review with …
WEBJan 16, 2024 · DNA damage is a critical factor contributing to genetic alterations, directly affecting human health, including developing diseases such as cancer and age-related …
DNA mismatch repair - Wikipedia
WEBDNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and …
24.2: DNA Mutations, Damage, and Repair - Biology LibreTexts
WEBThere are elaborate DNA repair processes designed to recognize and repair different types of DNA lesions. Fewer than 1 in 1,000 DNA lesions will result in a DNA mutation. The …
An Introduction to Molecular Biology/Replication of DNA and its …
WEBSep 4, 2020 · DNA is unwound and nucleotides are matched to make two new strands. As we know Cell division is essential for an organism to grow, but, when a cell divides, it …
A brief history of the DNA repair field | Cell Research - Nature
WEBDec 24, 2007 · The history of the repair of damaged DNA can be traced to the mid-1930s. Since then multiple DNA repair mechanisms, as well as other biological responses to …
DNA Repair - Molecular Biology of the Cell - NCBI …
WEBMaintaining genetic stability requires not only an extremely accurate mechanism for replicating DNA, but also mechanisms for repairing the many accidental lesions that occur continually in DNA. Most such …
Genetic recombination - Wikipedia
WEBRecA, the chief recombinase found in Escherichia coli, is responsible for the repair of DNA double strand breaks (DSBs). In yeast and other eukaryotic organisms there are two …
7.4: DNA Repair - Biology LibreTexts
WEBMar 21, 2024 · All DNA suffers damage over time, from exposure to ultraviolet and other radiation, as well as from various chemicals in the environment (Figures 7.34 & 7.35). …
Homologous recombination in DNA repair and DNA damage …
WEBJan 1, 2008 · Homologous recombination (HR) is a DNA metabolic process found in all forms of life that provides high-fidelity, template-dependent repair or tolerance of …
Nuclease - Wikipedia
WEBNucleases variously affect single and double stranded breaks in their target molecules. In living organisms, they are essential machinery for many aspects of DNA repair. Defects …
RecA - Wikipedia
WEBRecA is a 38 kilodalton protein essential for the repair and maintenance of DNA in bacteria. [2] . Structural and functional homologs to RecA have been found in all kingdoms of life. …
4.4: DNA Repair - Chemistry LibreTexts
WEBAug 23, 2021 · DNA damage. All DNA suffers damage over time, from exposure to ultraviolet and other radiation, as well as from various chemicals in the environment …
DNA replication - Wikipedia
WEBDNA replication occurs in all living organisms acting as the most essential part of biological inheritance. This is essential for cell division during growth and repair of damaged …
RNA-mediated double-strand break repair by end-joining …
WEB1 day ago · We propose two mechanisms of RNA-mediated DSB repair: RNA-mediated NHEJ (R-NHEJ) and RNA-mediated MMEJ (R-MMEJ). In these mechanisms, RNA, due …
Cell damage - Wikipedia
WEBThe most notable components of the cell that are targets of cell damage are the DNA and the cell membrane.. DNA damage: In human cells, both normal metabolic activities and …
Mitochondrial DNA - Wikipedia
WEBMitochondrial DNA is a small portion of the DNA contained in a eukaryotic cell; most of the DNA is in the cell nucleus, and, in plants and algae, the DNA also is found in plastids, …
Protein - Wikipedia
WEBA representation of the 3D structure of the protein myoglobin showing turquoise α-helices.This protein was the first to have its structure solved by X-ray …
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