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    How Histone Proteins Shape Your Genes
    How Histone Proteins Shape Your Genes
    How Histones Rule our Genes
    How Histones Rule our Genes
    Overview

    In biology, histones are highly basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei and in most Archaeal phyla. They act as spools around which DNA winds to create structural units called … See more

    Structure

    The nucleosome core is formed of two H2A-H2B dimers and a H3-H4 tetramer, forming two nearly symmetrical halves by tertiary structure (C2 symmetry; one macromolecule is the mirror image of the other). The H2A-H2B dimer… See more

    Evolution and species distribution

    Core histones are found in the nuclei of eukaryotic cells and in most Archaeal phyla, but not in bacteria. The unicellular algae known as dinoflagellates were previously thought to be the only eukaryotes that completely … See more

    Function

    Histones act as spools around which DNA winds. This enables the compaction necessary to fit the large genomes of eukaryotes inside cell nuclei: the compacted molecule is 40,000 times shorter tha… See more

     
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