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In the nucleus, DNA is tightly packaged into chromatin, a DNA–protein complex. The major protein component of chromatin consists of a group of highly basic proteins known as …

DNA histone interaction refers to the process where histone modifications, such as acetylation and methylation, influence the structure of chromatin by altering the accessibility of …

Oct 10, 2011 · Our detailed analysis of DNA-histone interactions revealed molecular mechanisms for modulating access to nucleosomal DNA via conformational rearrangements of its structure.

To elucidate the physicochemical properties of human histone/nucleosome interactions, we construct three human histone interaction networks including structural, cross-linking and high …

6 days ago · The interactions between DNA and histone with absorption energy can wind the DNA around the histone core, forming partially wrapped and mis-wrapped structures, and finally …

Thermodynamic information on the interaction of histones with DNA can be obtained from equilibrium binding curves and their variation with temperature, pH, ionic strength and so on.

Positively charged lysine residues, for instance in the histone H4 tail, can interact with negatively charged DNA or neighboring nucleosomes. Acetylation of the ɛ‐amino group of lysines occurs …

Because replication stress takes place in the context of chromatin, histone dynamics play key roles in modulating fork progression and replication stress responses. Here, we summarize the …

Feb 8, 2024 · The dynamic interactions between DNA and histones regulate DNA access while the strong DNA-histone interactions impose physical barriers to DNA binding and processing. …

Histone–DNA interactions are highly nonuniform within a nucleosome. There are three broad regions of strong interactions: one located at the dyad and two ∼±40 bp from the dyad.

Apr 22, 2021 · We identified atomistic mechanisms of these processes by analyzing the accompanying structural rearrangements of the histone octamer and histone-DNA contacts. …

Jan 11, 2009 · Here we present a detailed map of histone-DNA interactions along the DNA sequence to near base pair accuracy by mechanically unzipping single molecules of DNA, …

Histones are associated with DNA to form nucleosome essential for chromatin structure and major nuclear processes like gene regulation and expression. Histones consist of H1, H2A, H2B and …

Aug 19, 2021 · Using single-molecule DNA unzipping with optical tweezers, we reveal that linker histone interactions with DNA are remarkably extended, with the C-terminal domain binding …

Considerable progress has been made recently in defining the interactions of linker histones (H1s) within nucleosomes. Major advancements include atomic-resolution structures of the globular …

Oct 19, 2011 · Our detailed analysis of DNA-histone interactions revealed molecular mechanisms for modulating access to nucleosomal DNA via conformational rearrangements of its structure.

For real-time observation of the DNA-H2A interaction with HS-AFM, the scientists prepared DNA samples with different lengths and forms: plasmid (long and circular), long-linearized and...

We have utilized micrococcal nuclease digestion and thermal denaturation studies to investigate the binding of DNA to the histone core of the nucleosome. We conclude that a total of …

Mar 15, 2021 · Our findings indicate that histone H4 tails engage in a fuzzy interaction with nucleosomal DNA, underpinned by a variable pattern of short-lived salt bridges and hydrogen …

Jan 27, 2025 · Abstract. Nucleosomes, the chromatin building blocks, play an important role in controlling DNA and chromatin accessibility. Nucleosome remodeling and the incorporation of …

DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has become clear that the DNA and histone lysine methylation systems are highly interrelated and rely …

Jan 16, 2025 · The DNA damage response is accompanied by a reshaping of the chromatin landscape, including critical changes in histone post-translational modifications (PTMs) 11.

Oct 19, 2011 · Our detailed analysis of DNA-histone interactions revealed molecular mechanisms for modulating access to nucleosomal DNA via conformational rearrangements of its structure.