• The exact cause is not known. But the possible causes include:
• Biological differences:
• Different people have Different physical changes in the brain which might lead to this disease.
• Brain chemistry:
• Brain activities are controlled by neurotransmitters and the changes in neurotransmitters can be a cause of depression.
• Inherited traits:
• People with family history have more chances of developing the disease.
• It is believed that certain genes also play a role in occurrence of the disease.
• Life events:
• Traumatic events can be the cause of PDD, these may include:
• Loss of a loved one
• Financial problems
• High levels of stress

Treatment involves a combination of medication and psychotherapy.

Medication

Selective serotonin reuptake inhibitors (SSRIs): Helps to deal with depression by controlling the amount of seretonin in the body.

Fluoxetine . Sertraline

Tricyclic antidepressants: Most commonly used and highly efficient antidepressants.

Amitriptyline . Amoxapine

Serotonin and norepinephrine reuptake inhibitors (SNRIs): Helps in managing depression by controlling the amount of serotonin and norepinephrine in the body.

Desvenlafaxine . Duloxetine