Members of the Hsp70 family are very strongly upregulated by heat stress and toxic chemicals, particularly … See more

The Hsp70 proteins have three major functional domains:
• N-terminal ATPase domain – binds ATP (Adenosine triphosphate) and hydrolyzes it to ADP (Adenosine diphosphate). The NBD (nucleotide … See more

The Hsp70 system interacts with extended peptide segments of proteins as well as partially folded proteins to cause aggregation of proteins in key pathways to downregulate activity. When not interacting with a subs… See more

Hsp70 is overexpressed in malignant melanoma and underexpressed in renal cell cancer. In breast cancer cell line (MCF7) has been found that not only Hsp90 interacted with estrogen receptor alpha (ERα) but a… See more

Both Hsp70 and HSP47 were shown to be expressed in dermis and epidermis following laser irradiation, and the spatial and temporal changes in HSP expression patterns define the laser-induced thermal damage zo… See more