In 1988, researchers at Uppsala University Hospital and the Karolinska Institute in Stockholm mapped the MEN1 gene to the long arm of chromosome 11. The gene was finally cloned in … See more

The gene is located on long arm of chromosome 11 (11q13) between base pairs 64,570,985 and 64,578,765. It has 10 exons and … See more

Most germline or somatic mutations in the MEN1 gene predict truncation or absence of encoded menin resulting in the inability of MEN1 to act as a tumor suppressor gene. Such mutations in MEN1 have been associated with defective binding of encoded menin to … See more

• Tsukada T, Yamaguchi K, Kameya T (2002). "The MEN1 gene and associated diseases: an update". Endocrine Pathology. 12 (3): … See more

The MEN1 phenotype is inherited via an autosomal-dominant pattern and is associated with neoplasms of the pituitary gland, the … See more

MEN1 has been shown to interact with:
• FANCD2,
• GFAP,
• JunD,
• See more

• GeneReviews/NIH/NCBI/UW entry on Multiple Endocrine Neoplasia Type 1
• MEN1 gene variant database Archived 2017-10-10 at the Wayback Machine See more