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Neurofibromatosis Clinical Trials - Johns Hopkins Medicine
WEBThe neurofibromatosis team at Hopkins is building a clinical database that can predict which NF patients are most at risk for specific tumor types. With this improved accuracy, doctors can steer patients away from unnecessary screening.
Neurofibromatosis Clinical Trials - Mayo Clinic Research
WEBBrowse Clinical Trials. neurofibromatosis. Displaying 5 studies. The Collection of Blood Samples from Patients With NF1 for Research Purposes Rochester, MN. The objective …
FDA Approves First Ever Treatment for Neurofibromatosis
WEBApr 10, 2020 · The U.S. Food and Drug Administration (FDA) has approved Koselugo (selumetinib) for use in patients with inoperable plexiform neurofibromas, a common …
Brigatinib in NF2 -Related Schwannomatosis with Progressive …
WEBJun 20, 2024 · NF2 -related schwannomatosis (NF2 -SWN, formerly called neurofibromatosis type 2) is a tumor predisposition syndrome that is manifested by …
Selumetinib in Children with Inoperable Plexiform …
WEBMar 18, 2020 · In a phase 1 trial of the oral selective MEK inhibitor selumetinib (AZD6244 or ARRY-142886) involving 24 children with inoperable neurofibromatosis type 1–related plexiform neurofibromas, we...
Activity of Selumetinib in Neurofibromatosis Type …
WEBDec 29, 2016 · We conducted a phase 1 trial of selumetinib (AZD6244 or ARRY-142886), an oral selective inhibitor of MAPK kinase (MEK) 1 and 2, in children who had neurofibromatosis type 1 and inoperable ...
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Novel molecular targeted therapies for patients with …
WEBAug 10, 2021 · This comprehensive review aims to provide detailed information on the novel targeted therapies developed for patients with NF1 with inoperable PNs and ongoing …
Clinical Trials | Neurofibromatosis Center | Washington University …
WEBOur clinical trials aim to determine how drugs and other therapies can prevent or treat medical problems seen in individuals with NF1 and NF2. Search for additional current …
NF106: A Neurofibromatosis Clinical Trials Consortium Phase II …
WEBJan 28, 2021 · Purpose. Patients with neurofibromatosis type 1 (NF1) frequently develop plexiform neurofibromas (PNs), which can cause significant morbidity. We performed a …
NF106: A Neurofibromatosis Clinical Trials Consortium Phase II …
WEBMar 1, 2021 · Abstract. Purpose: Patients with neurofibromatosis type 1 (NF1) frequently develop plexiform neurofibromas (PNs), which can cause significant morbidity. We …
University of California Health Neurofibromatosis Clinical Trials ...
WEBAug 7, 2024 · MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas. This study evaluates mirdametinib (PD …
NF Clinical Trials Consortium - Neurofibromatosis Program
WEBNeurofibromatosis Clinical Trials Consortium. An international leader in advancing neurofibromatosis research, UAB serves as the national coordinating center for the NF …
Clinical trials targeting neurofibromatoses-associated tumors: a ...
WEBJan 16, 2022 · There is a paucity of literature that comprehensively analyzes previous and current clinical trials targeting neurofibromatoses-related tumors. This article aims to …
Neurofibromatosis Research Program, Clinical Trials Consortium ...
WEBMay 26, 2022 · The Neurofibromatosis Clinical Trials Consortium (NFCTC, http://www.uab.edu/nfconsortium) was established by the Department of Defense …
Cabozantinib for neurofibromatosis type 1–related plexiform ...
WEBJan 13, 2021 · Cabozantinib, an inhibitor of multiple receptor tyrosine kinases, has efficacy in a mouse model of neurofibromatosis type I and has clinical activity in reducing …
Clinical Trials for Neurofibromatosis - NYU Langone Health
WEBAs the only participating neurofibromatosis center in the New York tri-state region, we are pleased to offer such important and promising new treatments for people with …
A Systematic Review of Recent and Ongoing Clinical Trials in …
WEBThis study seeks to address this gap by presenting a systematic overview of recent and ongoing clinical trials for patients with the neurofibromatoses in order to better …
A Systematic Review of Recent and Ongoing Clinical Trials in
WEBThis review summarizes recent and ongoing clinical trials involving patients with neurofibromatoses to better understand the current state of clinical trial research …
Translating current basic research into future therapies for ...
WEBMay 22, 2020 · This knowledge has been translated into clinical trials of putative therapeutic targets in an attempt to develop new treatments for NF1 (Fig. 1).
Neurofibromatosis Clinic - Overview - Mayo Clinic
WEBJun 12, 2024 · We provide clinical evaluations for neurofibromatosis (type 1 and type 2) and schwannomatosis — and all of our physicians have significant experience treating …
WEBNF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform …
Neurofibromatosis - National Institute of Neurological Disorders …
WEBJul 19, 2024 · Clinical trials. NINDS supports clinical trials aimed at understanding tumor growth and cognitive impairments in children, including: Studying the natural history of …
Home - Neurofibromatosis Consortium - The University of …
WEBThe NF Clinical Trials Consortium was formed in 2006 with funding from the U.S. Army Medical Research and Materiel Command to carry out clinical trials of such medications.
Potential of Advancing Neurofibromatosis Care With …
WEB1 day ago · Top Clinical Takeaways. Mirdametinib has the potential to become the first FDA-approved treatment for adults with NF1-PN, addressing a significant unmet need. …
Unraveling neuronal and metabolic alterations in …
WEB5 days ago · Neurofibromatosis type 1 (NF1) is a multisystemic autosomal-dominant condition affecting ~ 1 in 3,000 live births worldwide [1,2,3,4].Historical recognition of the …
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