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Organoid - Wikipedia
An organoid is a miniaturised and simplified version of an organ produced in vitro in three dimensions that mimics the key functional, structural, and biological complexity of that organ. It is derived from one or a few cells from a tissue, embryonic stem cells, or induced pluripotent stem cells, … See more
Attempts to create organs in vitro started with one of the first dissociation-reaggregation experiments where Henry Van Peters Wilson demonstrated that mechanically … See more
Lancaster and Knoblich define an organoid as a collection of organ-specific cell types that develops from stem cells or organ progenitors, self-organizes through cell sorting and … See more
A multitude of organ structures have been recapitulated using organoids. This section aims to outline the state of the field as of now through providing an abridged list of the organoids that have been successfully created, along with a brief outline based on the most recent … See more
Organoids provide an opportunity to create cellular models of human disease, which can be studied in the laboratory to better understand the causes of disease and identify possible treatments. The power of organoids in this regard was first shown for a genetic form of See more
early 2010sThe technique for growing organoids has rapidly improved1987Researchers have devised different methods for 3D culturing2006Yaakov Nahmias and David Odde showed the self-assembly of vascular liver organoid maintained for over 50 days in vitro2008Yoshiki Sasai and his team at RIKEN institute demonstrated that stem cells can be coaxed into balls of neural cells that self-organize into distinctive layers2009The Laboratory of Hans Clevers at Hubrecht Institute and University Medical Center Utrecht, Netherlands, showed that single LGR5-expressing intestinal stem cells self-organize to crypt-villus structures in vitro without necessity of a mesenchymal niche, making them the first organoids2010Mathieu Unbekandt & Jamie A. Davies demonstrated the production of renal organoids from murine fetus-derived renogenic stem cells2013Madeline Lancaster at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences established a protocol starting from pluripotent stem cells to generate cerebral organoids that mimic the developing human brain's cellular organization2014Qun Wang and co-workers engineered collagen-I and laminin based gels and synthetic foam biomaterials for the culture and delivery of intestinal organoids and encapsulated DNA-functionalized gold nanoparticles into intestinal organoids to form an intestinal Trojan horse for drug delivery and gene therapy2014Artem Shkumatov et al. at the University of Illinois at Urbana-Champaign demonstrated that cardiovascular organoids can be formed from ES cells through modulation of the substrate stiffness, to which they adhere2022The first successful transplantation of an organoid into a human, a patient with ulcerative colitis whose cells were used for the organoid, was carried outOrganoid formation generally requires culturing the stem cells or progenitor cells in a 3D medium. Stem cells have the ability to self-renew and differentiate into various cell … See more
Organoids enable to study how cells interact together in an organ, their interaction with their environment, how diseases affect them and the effect of drugs. In vitro culture makes this system easy to manipulate and facilitates their monitoring. While … See more
Intestinal organoids grown from rectal biopsies using culture protocols established by the Clevers group have been used to model See more
Wikipedia text under CC-BY-SA license Cerebral organoid - Wikipedia
A neural, or brain organoid, describes an artificially grown, in vitro, tissue resembling parts of the human brain. Neural organoids are created by culturing pluripotent stem cells into a three-dimensional culture that can be maintained for years. The brain is an extremely complex system of heterogeneous tissues and consists of a diverse array of neurons and glial cells. This complexity has made studying the brain and understanding how it works a difficult task in neuroscience, es…
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Organoid intelligence - Wikipedia
Organoid intelligence (OI) is an emerging field of study in computer science and biology that develops and studies biological computing using 3D cultures of human brain cells (or brain …
What Is an Organoid? : ScienceAlert
Organoids are small, simplified, 3D copies of organs created outside of a living body, usually grown by treating combinations of tissues or stem cells with the nutrients and chemical signals …
Organoids: A new window into disease, development and discovery
Nov 7, 2017 — Organoids are tiny, self-organized three-dimensional tissue cultures that are derived from stem cells. Such cultures can be crafted to replicate much of the complexity of an …
Human organoids: model systems for human biology and medicine
Jul 7, 2020 — Human organoids are valuable models for the study of development and disease and for drug discovery, thus complementing traditional animal models. The generation of organoids …
Experimental microscopic organs: enter the organoid
May 6, 2021 — First fully realized and developed in the early 2010s, an organoid is a miniaturized and simplified version of an organ produced in vitro (or outside the entire organism: on their own). The organoid has significant use for …
What Are Organoids and How Are They Made? - The Scientist
Aug 11, 2022 — Organoids are 3D cell cultures derived from pluripotent stem cells that mimic the structure, function, and cellular complexity of human organs.
Organoids: The current status and biomedical applications - PMC
May 17, 2023 — Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are derived from cells with stem potential and can self‐organize and differentiate into 3D …
Human organoids: a new dimension in cell biology - PMC
May 1, 2019 — Organoids originate from renewable tissue sources that self-organize in culture to acquire in vivo-like organ complexity. Organoids can be generated from human cell sources, …
A brief history of organoids - National Center for Biotechnology ...
Jul 1, 2020 — The modern term organoid refers to cells growing in a defined three-dimensional (3D) environment in vitro to form mini-clusters of cells that self-organize and differentiate into …
A brief history of organoids | American Journal of Physiology-Cell ...
Jul 7, 2020 — The modern term organoid refers to cells growing in a defined three-dimensional (3D) environment in vitro to form mini-clusters of cells that self-organize and differentiate into …
The Cerebral Organoid, a Lab-Grown Model Brain - National …
Aug 28, 2013 — An organoid is a lab-grown, three-dimensional ball of cells that has some of the features of a normal organ. In recent years, scientists have made organoids for intestines, …
An Introduction to Organoids, Organoid Creation, Culture and ...
Jan 17, 2023 — Organoids have revolutionized biological and medical research and proven to be excellent substitutes for animal models in preclinical studies. Here, we discuss what organoids …
A brief history of organoids - PubMed
Jul 1, 2020 — In this review, we provide an overview of the organoid history and development. We discuss the strengths and limitations of organoids as well as their potential applications in the …
Organoids | Nature Methods
Jan 3, 2018 — An organoid is a 3D multicellular in vitro tissue construct that mimics its corresponding in vivo organ, such that it can be used to study aspects of that organ in the …
Organoids and mini-organs: Introduction, history, and potential
Jan 1, 2018 — Organoids are three-dimensional assemblies that contain multiple cell types, arranged similarly to the cells in a specific tissue, at least at the micro-scale; mini-organs add …
オルガノイド - Wikipedia
オルガノイド(英:organoid)、試験管内など生体外(in vitro)、3次元(3D)的につくられた臓器である。「器官」(organ)と「~もどき」(-oid)を組み合わせた造語 [1] 。
Organoids | Nature Reviews Methods Primers
Dec 1, 2022 — Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo …
Organoid - an overview | ScienceDirect Topics
An organoid is a miniaturized and simplified version of an organ produced in vitro from differentiated cells, embryonic stem cells, or induced pluripotent stem cells that self-organize in …
What are organoids - Monash Biomedicine Discovery Institute
Organoids are an innovative three-dimensional cell culture system that holds tremendous potential for personalised medicine and ground breaking discovery research. They are …
Organoid - an overview | ScienceDirect Topics
By way of definition, an organoid is a cellular structure grown in vitro that contains multiple cell types in patterned geometric arrangements that resemble a tissue or organ of the body. From: …
Nevus sebaceous - Wikipedia
Nevus sebaceus or sebaceous nevus (the first term is its Latin name, the second term is its name in English; also known as an "organoid nevus" [1]: 661 and "nevus sebaceus of Jadassohn" …
Organoïde — Wikipédia
Organoïde. Organoïde intestinal cultivé à partir de cellules souches Lgr5+. Un organoïde est une version miniature et simplifiée d'un organe, fabriquée in vitro en trois dimensions et qui …