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- Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone reverse insulin resistance receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor functioning as a transcription factor that in humans is encoded by the PPAR...Learn more:Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone reverse insulin resistance receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor functioning as a transcription factor that in humans is encoded by the PPAR...en.wikipedia.org/wiki/Peroxisome_proliferator-activ…Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-modulated transcription factor that governs the expression of genes involved in inflammation, redox equilibrium, trophic factor production, insulin sensitivity, and the metabolism of lipids and glucose.pubmed.ncbi.nlm.nih.gov/29032144/Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of a class of nuclear hormone receptors intimately involved in the regulation of expression of myriad genes that regulate energy metabolism, cell differentiation, apoptosis and inflammation.pubmed.ncbi.nlm.nih.gov/11900961/PPARγ (gamma) is the main target of the drug class of thiazolidinediones (TZDs), used in diabetes mellitus and other diseases that feature insulin resistance. It is also mildly activated by certain NSAIDs (such as ibuprofen) and indoles, as well as from a number of natural compounds.en.wikipedia.org/wiki/PPAR_agonist
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See all on WikipediaPeroxisome proliferator-activated receptor gamma - Wikipedia
Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone reverse insulin resistance receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor functioning as a transcription factor that in humans is encoded by the PPARG gene. See more
PPARG is mainly present in adipose tissue, colon and macrophages. Two isoforms of PPARG are detected in the human and in the mouse: PPAR-γ1 (found in nearly all tissues … See more
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form … See more
Peroxisome proliferator-activated receptor gamma has been shown to interact with:
• Tetrahydrocannabivarin
• See more• Endocannabinoid system
• Endocannainoidome See more
PPARG regulates fatty acid storage and glucose metabolism. The genes activated by PPARG stimulate lipid uptake and adipogenesis by fat cells. PPARG knockout mice are devoid of adipose tissue, establishing PPARG as a master regulator of See more
PPAR-gamma agonists have been used in the treatment of hyperlipidaemia and hyperglycemia.
Many insulin sensitizing drugs (namely, the thiazolidinediones) used in the treatment of diabetes activate PPARG as a means to lower … See moreWikipedia text under CC-BY-SA license Peroxisome proliferator-activated receptor - Wikipedia
All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. These DNA sequences are termed PPREs (peroxisome proliferator hormone response elements). The DNA consensus sequence is AGGTCANAGGTCA, with N being any nucleotide. In general, this sequence occurs in the promoter region of a gene, and, when the PPAR binds its ligand, transcription of target genes is increased or decreased, depending on the …
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PPAR agonist - Wikipedia
PPAR agonists are drugs which act upon the peroxisome proliferator-activated receptor. They are used for the treatment of symptoms of the metabolic syndrome, mainly for lowering …
The peroxisome proliferator-activated receptor: A family of nuclear ...
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, …
PPARG Gene - Peroxisome Proliferator Activated …
Dec 25, 2024 · Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene …
Roles of Peroxisome Proliferator-Activated Receptor-gamma on …
Peroxisome proliferator-activated receptor-gamma (PPARγ) has been implicated in the pathology of numerous diseases involving diabetes, stroke, cancer or obesity. It is expressed in diverse …
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Peroxisome proliferator-activated receptor γ (PPARγ): …
Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-modulated transcription factor that governs the expression of genes involved in inflammation, redox equilibrium, trophic factor production, insulin …
Roles of Peroxisome Proliferator-Activated Receptor Gamma on …
Peroxisome proliferator-activated receptor gamma (PPARγ) has been implicated in the pathology of numerous diseases involving diabetes, stroke, cancer, or obesity. It is expressed in diverse …
Peroxisome Proliferator Activated Receptor Gamma
Peroxisome proliferator-activated receptor gamma (PPARG) is a target receptor for tumor necrosis factor receptor superfamily, member 11 B (TNFRSF11B), which is also called …
Peroxisome proliferator-activated receptor gamma coactivator-1 …
Mar 1, 2024 · Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …
Therapeutic Roles of Peroxisome Proliferator–Activated Receptor ...
Aug 1, 2005 · Peroxisome proliferator–activated receptors (PPARs) play key roles in the regulation of energy homeostasis and inflammation, and agonists of PPARα and -γ are …
Pparg coactivator 1 alpha - Wikipedia
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. [4] PPARGC1A is also known as human …
Peroxisome proliferator-activated receptor gamma …
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of a class of nuclear hormone receptors intimately involved in the regulation of expression of myriad genes …
The mechanisms of action of PPARs - PubMed
The peroxisome proliferator-activated receptors (PPARs) are a group of three nuclear receptor isoforms, PPAR gamma, PPAR alpha, and PPAR delta, encoded by different genes. PPARs …
Peroxisome proliferator-activated receptor γ (PPARγ): A master ...
Apr 1, 2018 · Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-modulated transcription factor that governs the expression of genes involved in inflammation, …
Peroxisome proliferator-activated receptor alpha - Wikipedia
Peroxisome proliferator-activated receptor alpha (PPAR-α), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning as a …
Peroxisome proliferator-activated receptor-gamma: a versatile
The peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor that controls the expression of a large array of genes involved in adipocyte differentiation, lipid …
Peroxisome Proliferator Activated Receptor Gamma
Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a lipid-activated transcription factor that has been implicated in several types of dysregulation of metabolic function, …
Peroxisome proliferator-activated receptor alpha is an ... - Nature
5 days ago · We report that peroxisome proliferator-activated receptor alpha (PPARα), a transcription factor that regulates genes critical for lipid metabolism, is a key molecule in the …
Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-ɣ
PPAR-ɣ can interact with specific DNA response elements to control gene transcription and expression when triggered by its ligand. It regulates lipid metabolism, improves insulin …
Receptor activat per proliferadors peroxisomals - Viquipèdia, l ...
En el camp de la biologia molecular, els receptors activats per proliferadors peroxisomals (PPAR) son un grup de proteïnes receptores nuclears que funcionen com a factors de transcripció …
Peroxisome proliferator-activated receptor γ (PPARγ): A master ...
Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-modulated transcription factor that governs the expression of genes involved in inflammation, redox …
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