Restless legs syndrome - Search
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  1. Restless legs syndrome
    Restless legs syndromeNeurological disorder
    SymptomsCausesDiagnosisTreatmentsDoctorsClinical trials
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  2. Restless legs syndrome - Overview

    Verified Expert
    Also known as: willis-ekbom disease
    A disorder that causes an overwhelming urge to move legs, usually associated with unpleasant sensations often during sleep and relieved by movement.
    How common is condition?
    Very common (More than 3 million cases per year in US)
    Is condition treatable?
    Treatments can help manage condition, no known cure
    Does diagnosis require lab test or imaging?
    Doesn't require lab test or imaging
    Condition Highlight
    Family history may increase likelihood
    See more

    Causes

    Verified Expert

    • The exact cause is not known
    • Family history - it is believed to be hereditary
    • Abnormalities in the brain can lead to this condition
    • Neurotransmitters (chemicals that help to transmit signal to the brain) abnormalities can cause this problem
    • The conditions which are likely to cause restless leg syndrome include
    • The iron deficiency anemia
    • Peripheral neuropathy - damage to the nerves of limbs due to underlying conditions such as diabetes
    • Parkinson's disease
    • Varicose veins
    • Fibromyalgia
    • Hyper- or hypothyroidism (over- or underactive thyroid glands)
    • Severe kidney disease and uremia (kidney failure causing build up of toxins within the body)
    • Amyloidosis (build-up of a starch-like substance in the body's tissues and organs)
    • Lyme disease
    • Damage to spinal nerves
    • Rheumatoid arthritis
    • Sjögren syndrome
    • Pregnancy

    See more

    Symptoms

    Verified Expert
    Contact your provider if experiencing new, severe, or persistent symptoms.

    The major symptom is urging to move your legs, especially after rest and worsens in the evening. The other symptoms include:

    • Tingling, burning or itching
    • A creepy-crawly feeling
    • Feeling like fizzy water is inside the blood vessels in the legs
    • A painful, cramping sensation in the legs, particularly in the calves
    • Leg jerking
    • Pulling - feeling of pulling in the legs
    • Throbbing - sensation of throbbing near the calves
    • Aching- leg pain

    See more

    Treatment

    Verified Expert

    Treatment involves managing the underlying conditions.

    Medication

    Iron Replacement: Iron replacement is suggested whose fasting serum ferritin levels are < 75 micrograms/litre. Usually recommended when the condition is secondary to iron deficiency anemia.

    Ferrous sulphate . Ferric carboxymaltose

    Antidepressants: To reduce the symptoms of depression, which may result to disturbed sleep pattern.

    Buproprion . Ropinirole . Rotigotine . Pramipexole

    Calcium channel regulators: Work for some chronic, persistent cases. Usually recommended in some cases.

    Gabapentin . Pregabalin

    Narcotic medication: Usually addictive and are used if other drugs do not work. Usually recommended in some cases.

    Oxycodone . Hydrocodone

    Sedatives: To help sleep better.

    Clonazepam . Eszopiclone . Temazepam

    See more
    restless legs syndrome_en
    Microsoft Start Health

    Diagnosis

    Verified Expert
    One or more of these tests may be recommended by your medical provider.
    The condition is usually self-diagnosable and tests are usually required to rule out any other condition with similar symptoms.

    Common tests & procedures

    Polysomnography: In certain cases polysomnography (sleep study, to check the leg movement during sleep) may be done.

    Electromyography (EMG): To detect the leg movements during sleep.

    Iron deficiency test: To check for iron deficiency.

    See more
    Source: Focus Medica. For informational purposes only. Consult a medical professional for advice. | Disclaimer: Opinions are from external health professionals and should not be considered as Microsoft's opinion or a substitute for professional help. Consult a health professional for medical advice.
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  2. Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/restless...

    Restless legs syndrome - Symptoms and causes - Mayo …

     
  3. Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/restless...

    Restless legs syndrome - Diagnosis and treatment

  4. Cleveland Clinic
    https://my.clevelandclinic.org/health/diseases/9497-restless

    Restless Legs Syndrome (RLS): Causes, Symptoms

  5. National Institute of Neurological Disorders and Stroke
    https://www.ninds.nih.gov/.../restless-legs-syndrome

    Restless Legs Syndrome | National Institute of …

  6. WebMD
    https://www.webmd.com/brain/restless-legs-syndrome...

    Restless Legs Syndrome (RLS): Causes, Symptoms

  7. Johns Hopkins Medicine
    https://www.hopkinsmedicine.org/health/conditions-and...

    Restless Legs Syndrome (RLS) | Johns Hopkins Medicine

  8. Interesting reads - Restless legs syndrome

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  9. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/books/NBK430878

    Restless Legs Syndrome - StatPearls - NCBI Bookshelf

    WEBFeb 27, 2023 · Restless legs syndrome (RLS), or Willis-Ekbom disease, is a common, chronic, multifactorial movement disorder of the limbs in which patients have an irresistible urge to move legs. This is often …