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TGF alpha - Wikipedia
TGF-α is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. See more
Transforming growth factor alpha (TGF-α) is a protein that in humans is encoded by the TGFA gene. As a member of the epidermal growth factor (EGF) family, TGF-α is a mitogenic polypeptide. The protein becomes activated … See more
TGF-α can be produced in macrophages, brain cells, and keratinocytes. TGF-α induces epithelial development. Considering that TGF-α is a member of the EGF family, the biological actions of TGF-α and EGF are similar. For instance, TGF-α and EGF … See more
In an animal model of Parkinson's disease where dopaminergic neurons have been damaged by 6-hydroxydopamine, infusion of TGF-α into the brain caused an increase in the number of neuronal precursor cells. However TGF-α treatment did not result in … See more
TGF-α is synthesized internally as part of a 160 (human) or 159 (rat) amino acid transmembrane precursor. The precursor is composed of an … See more
A 170-kDa glycosylated protein known as the EGF receptor binds to TGF-α allowing the polypeptide to function in various signaling pathways. The EGF receptor is characterized by having an extracellular domain that has numerous amino acid motifs. EGFR is … See more
Neuroendocrine system
The EGF/TGF-α family has been shown to regulate luteinizing hormone-releasing hormone (LHRH) through a glial-neuronal interactive process. … See moreWikipedia text under CC-BY-SA license Transforming growth factor - Wikipedia
• TGFα is upregulated in some human cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It belongs to the EGF family.
• TGFβ exists in three known subtypes in humans, TGFβ1, TGFβ2, and TGFβ3. These are upregulated in Marfan's syndrome and some human cancers, and play crucial roles in tissue regeneration, cell differentiation, embryonic development, and regulation of the immune system. Isoforms of trans…Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 2 mins
Transforming Growth Factor Alpha - an overview - ScienceDirect
Transforming Growth Factor Alpha (TGF-α) is a protein that acts as a potent agonist of EGFR and has been found to have increased expression in recurrent meningiomas. It is also …
TGF-α - Wikipedia
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TGF Alpha - an overview | ScienceDirect Topics
Transforming growth factor alpha (TGFα) is perhaps the best studied member of the EGF family. It was initially identified in the conditioned media of sarcoma cells through its ability to promote a …
Transforming Growth Factor α and β (TGF-α and TGF-β)
Mar 11, 2016 · Transforming Growth Factor alpha (TGF-α) is a protein structurally similar to Epidermal Growth Factor (EGF) and a ligand for EGF-receptors, competing with Epidermal Growth Factors. It has been found in a variety of …
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TGF-α - Wikipedia
TGF-α （transforming growth factor alpha）は、ヒトでは TGFA 遺伝子 にコードされる タンパク質 である [5]。 TGF-αは EGFファミリー のメンバーであり、 分裂促進因子 としての活性を …
TGF alpha - wikidoc
TGF-α is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This …
トランスフォーミング増殖因子 - Wikipedia
トランスフォーミング増殖因子 （トランスフォーミングぞうしょくいんし、Transforming growth factor、 TGF）または トランスフォーミング成長因子 （トランスフォーミングせいちょう …
Transforming Growth Factor α: A Promoter of Motoneuron …
Sep 9, 2001 · Expression of transforming growth factor α (TGFα), a member of the epidermal growth factor (EGF) family, is a general response of adult murine motoneurons to genetic and …
TGFA Gene - GeneCards | TGFA Protein | TGFA …
Dec 25, 2024 · TGFA (Transforming Growth Factor Alpha) is a Protein Coding gene. Diseases associated with TGFA include Tooth Agenesis and Cleft Lip. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts …
TGF Alpha - an overview | ScienceDirect Topics
Transforming growth factor-α (TGFα) is an epidermal growth factor (EGF) superfamily member, and is produced by Sertoli, peritubular, and Leydig cells. From: Handbook of Cell Signaling …
转化生长因子-β - 维基百科，自由的百科全书
转化生长因子-β （Transforming growth factor beta，TGF-β）是一多功能蛋白质，可以影响多种 细胞 的生长，分化、 细胞凋亡 及 免疫 调节等功能，转化生长因子-β包括三个亚型， 转化生 …
From wavy hair to naked proteins: The role of transforming growth ...
Since its discovery in 1978 and cloning in 1984, transforming growth factor-alpha (TGF α, TGFA) has been one of the most extensively studied EGF receptor (EGFR) ligands. In this review, we …
Transforming Growth Factor α: Expression and Biological
Transforming growth factor α (TGFα) is a potent polypeptide mitogen that was first identified in the culture fluids of retroviral (1) and chemically transformed (2) cells.
Transforming Growth Factor α (TGFα)-Stimulated Secretion of …
Mar 10, 2008 · Transforming growth factor α (TGFα) belongs to the epidermal growth factor (EGF) family, which has 10 members in humans. The mature form of TGFα is a 50-amino-acid …
Transforming Growth Factor Alpha - an overview - ScienceDirect
Transforming growth factor alpha (TGFα), epidermal growth factor, epidermal growth factor receptor, and fibroblast growth factor are all growth factors that have been implicated in the …
Transforming growth factor α disrupts the normal program of …
Jan 1, 1995 · Transforming growth factor alpha (TGFα) evokes diverse responses in transgenic mouse tissues in which it is over-expressed, including the gastric mucosa, which experiences …
TGF alpha - NamuWiki
Transforming growth factor α. (TGFα, TGFa) TGFα is a subfamily of epidermal growth factors (EGFs), which bind to the EGF receptor and use the RTK pathway similar to EGF. TGFα is …
Transforming Growth Factor Alpha - an overview - ScienceDirect
Transforming growth factor alpha (TGFα) is perhaps the best studied member of the EGF family. It was initially identified in the conditioned media of sarcoma cells through its ability to promote a …
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