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    Xq28 - Wikipedia

    Xq28 is a chromosome band and genetic marker situated at the tip of the X chromosome which has been studied since at least 1980. The band contains three distinct regions, totaling about 8 Mbp of genetic information. The marker came to the public eye in 1993 when studies by Dean Hamer and … See more

    The 1993 study by Hamer et al. examined 114 families of gay men in the United States and found increased rates of homosexuality … See more

    Xq28 is a large, complex, and gene-dense region. Among its various genes are the 12 genes of the melanoma-associated antigen (MAGE) family, of which MAGEA11 has been identified as a coregulator for the androgen receptor. Mutations involving … See more

    Two further studies in the 1990s gave mixed results. One was an X chromosome linkage analysis of 54 pairs of gay brothers carried out by the … See more

    Molecular Genetic Study of Sexual Orientation Archived 2010-03-02 at the Wayback Machine A genetic study of gay brothers at Northwestern University. See more

     
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  3. Dean Hamer - Wikipedia

  4. MECP2 duplication syndrome - Wikipedia

  5. MECP2 Duplication Syndrome - Symptoms, Causes, Treatment

  6. Xq28 Duplication Syndrome, Int22h1/Int22h2 Mediated

    Mar 10, 2016 · The int22h1/int22h2-mediated Xq28 duplication syndrome is an X-linked intellectual disability syndrome characterized by variable degrees of …

    • Author: Ayman W El-Hattab, Christian P Schaaf, Sau Wai Cheung
    • Published: 2021/02/25
    • Publish Year: 2016
  7. Chromosome Xq28 duplication syndrome - NIH Genetic Testing …

  8. People also ask
    What is Xq28 chromosome?
    Xq28 is a chromosome band and genetic marker situated at the tip of the X chromosome which has been studied since at least 1980. [ 1] The band contains three distinct regions, totaling about 8 Mbp of genetic information. [ 2]
    en.wikipedia.org
    Is chromosome Xq28 a functional disomy?
    Duplications leading to functional disomy of chromosome Xq28, including MECP2 as the critical dosage-sensitive gene, are associated with a distinct clinical phenotype in males, characterized by severe mental retardation, infantile hypotonia, progressive neurologic impairment, recurrent infections, bladder dysfunction, and absent speech.
    How do we describe Xq28 genes?
    By using a systematic approach, we describe the Xq28 genes by RNA in situ hybridisation and Northern blotting of the mouse orthologs, as well as subcellular localisation and data mining of the human genes. We have developed a relational web-accessible database with comprehensive query options integrating all experimental data.
    What are Xq28 map and disease regions?
    Xq28 map and disease regions. The Xq28 region is shown in a megabase scale and regions of Xq28-mapped diseases are shown as different colored lines. Candidate genes discussed in the text are shown in red. Genetic markers are shown in green.
    Why does the Xq28 chromosome break off?
    In these specific cases, the Xq28 region breaks off and attaches to an autosome (non-sex chromosome). Because the duplicated material on the X chromosome has been translocated to an autosome, this prevents the normal X-inactivation of the duplicated segment. An unbalanced translocation occurs randomly (de novo).
    Could Xq28 contain a 'gay gene'?
    In 1993 geneticist Dean Hamer of the U.S. National Cancer Institute and his colleagues published a paper suggesting that an area on the X chromosome called Xq28 could contain a “gay gene.”
  9. Orphanet: Proximal Xq28 duplication syndrome

  10. Retiring the Single Gay Gene Hypothesis - DNA Science

  11. MECP2 Duplication Syndrome - GeneReviews® - NCBI Bookshelf

  12. The life of the gay gene: from hypothetical genetic marker to …

  13. The systematic functional characterisation of Xq28 genes …

  14. Clinical impacts of genomic copy number gains at Xq28

  15. Xq28 Duplication Syndrome, Int22h1/Int22h2 Mediated - PubMed

  16. Massive Study Finds No Single Genetic Cause of Same-Sex …

  17. Xq28 - Wikipedia

  18. MECP2 duplication syndrome: MedlinePlus Genetics

  19. Study of gay brothers may confirm X chromosome link to …

  20. Xq28 - Wikiwand articles

  21. The systematic functional characterisation of Xq28 genes …

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  23. MECP2 duplications in six patients with complex sex …

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  25. Xq28 – Wikipédia

  26. Xq28 duplications including MECP2 in five females: Expanding …