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  1. Zollinger ellison syndrome - Overview

    Verified Expert
    Also known as: Z-E syndrome, gastrinoma
    A condition where the body produces an excess of the gastrin hormone that causes stomach to produce too much acid. This causes peptic ulcers and diarrhea.
    Condition Highlight
    Urgent medical attention is usually recommended by healthcare providers
    Condition Highlight
    Can be dangerous or life threatening if untreated
    How common is condition?
    Extremely rare (Fewer than 1,000 cases per year in US)
    Is condition treatable?
    Treatable by a medical professional
    Does diagnosis require lab test or imaging?
    Requires lab test or imaging
    Time taken for recovery
    Can last several months or years
    Condition Highlight
    Common for ages 20-50
    Condition Highlight
    More common in males
    Condition Highlight
    Family history may increase likelihood
    See more

    Causes

    Verified Expert

    • This condition can be caused by tumors called gastrinomas found often on the head of the pancreas and upper small intestines. These gastrinomas secrete a hormone called gastrin.
    • High levels of gastrin cause production of excess stomach acid, which leads to peptic ulcer.
    • The risk factors include:
    • Family history - this is likely run in families

    See more

    Symptoms

    Verified Expert
    Seek immediate medical attention if you experience symptoms.

    Symptoms may include:

    • Nausea
    • Vomiting
    • Abdominal pain
    • Diarrhea
    • Weight loss
    • Loss of appetite
    • Bloating and burping

    See more
    How does Zollinger-Ellison syndrome affect the stomach?
    Gastrinomas produce large amounts of the hormone gastrin, which is what triggers your stomach to produce gastric acid. Too much gastrin leads to too much stomach acid, which can cause ulcers in your stomach and duodenum. ZES is also known as pancreatic ulcerogenic tumor syndrome. How does Zollinger-Ellison syndrome affect me?
    my.clevelandclinic.org

    Treatment

    Verified Expert

    The methods of managing this disease include medication and surgery.

    Medication

    Proton pump inhibitors: Used to stop acid reflux, relieve pain caused by peptic ulcers and encourage healing.

    Esomeprazole . Omeprazole . Pantoprazole

    Chemotherapeutic agents: Used to treat gastrinomas that cannot be removed surgically.

    Streptozotocin . Doxorubicin . 5-fluorouracil

    Chemotherapy: In case, if the tumor is found to be of cancerous nature, a combination of chemotherapy, targeted radiation therapy may be advised.

    Streptozocin/Fluorouracil

    See more
    zollinger ellison syndrome_en
    Microsoft Start Health

    Diagnosis

    Verified Expert
    One or more of these tests may be recommended by your medical provider.
    If Zollinger-Ellison syndrome is suspected, several tests are carried out.

    Common tests & procedures

    Blood test: To check gastrin levels. High levels indicates the condition.

    Imaging tests: To locate and find the size of the tumors.

    Endoscopy: To check for ulcers and take samples of the tumors.

    See more
    Source: Focus Medica. For informational purposes only. Consult a medical professional for advice. | Disclaimer: Opinions are from external health professionals and should not be considered as Microsoft's opinion or a substitute for professional help. Consult a health professional for medical advice.
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    Table of Contents
    Overview
    Causes
    Symptoms
    How does Zollinger-Ellison syndrome affect the stomach?
    Treatment
    Health guide
    Diagnosis
     

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    Wikipedia
    https://en.wikipedia.org/wiki/Zollinger–Ellison...

    Zollinger–Ellison syndrome - Wikipedia

    Zollinger–Ellison syndrome (Z-E syndrome) is a rare disease in which tumors cause the stomach to produce too much acid, resulting in peptic ulcers. Symptoms include abdominal pain and diarrhea. The syndrome is caused by a gastrinoma, a neuroendocrine tumor that secretes a hormone called gastrin. … See more

    Signs and symptoms

    Patients with Zollinger–Ellison syndrome may experience abdominal pain and diarrhea. If left untreated, the condition could result in severe … See more

    Pathophysiology

    Gastrin works on the parietal cells of the gastric glands, causing them to secrete more hydrogen ions into the stomach lumen. … See more

    Treatment

    Proton pump inhibitors (such as omeprazole and lansoprazole) and histamine H2-receptor antagonists (such as See more

    History

    Sporadic reports of unusual cases of peptic ulceration in the presence of pancreatic tumors occurred prior to 1955, but Robert M. Zollinger and Edwin H. Ellison, surgeons at See more

    Overview image
    Diagnosis

    Zollinger–Ellison syndrome may be suspected when the above symptoms prove resistant to treatment when the symptoms are … See more

    Epidemiology

    The condition most commonly affects people between the ages of 30 and 60. The prevalence is unknown, but estimated to be about 1 in … See more

    From Wikipedia
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  3. Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/...

    Zollinger-Ellison syndrome - Symptoms and causes - Mayo Clinic

  4. Johns Hopkins Medicine
    https://www.hopkinsmedicine.org/healt…

    Zollinger-Ellison Syndrome - Johns Hopkins Medicine

    Zollinger-Ellison syndrome is a rare digestive disorder that results in too much gastric acid. This excess gastric acid can cause peptic ulcers in your stomach and intestine. Symptoms include abdominal pain, nausea, vomiting, weight loss, …

  5. Wikipedia
    https://en.wikipedia.org/wiki/Gastrinoma

    Gastrinoma - Wikipedia

  6. Cleveland Clinic
    https://my.clevelandclinic.org/health/dis…

    Zollinger-Ellison Syndrome - Cleveland Clinic

    Nov 9, 2022 · Zollinger-Ellison syndrome (ZES) is a very rare condition that affects your digestive system. It results from a type of tumor called a gastrinoma which may develop in your pancreas and/or duodenum (the top of your small …

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  7. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/books/NBK537344

    Zollinger-Ellison Syndrome - StatPearls - NCBI Bookshelf

    Nov 21, 2022 · Zollinger-Ellison syndrome (ZES) is a group of symptoms comprised of severe peptic ulcer disease, gastroesophageal reflux disease (GERD), and chronic diarrhea caused by a gastrin-secreting tumor of the …

  8. People also ask
    What is Zollinger-Ellison syndrome (z-E syndrome)?
    Zollinger–Ellison syndrome (Z-E syndrome) is rare disease in which tumors cause the stomach to produce too much acid, resulting in peptic ulcers. Symptoms include abdominal pain and diarrhea. The syndrome is caused by a gastrinoma, a neuroendocrine tumor that secretes a hormone called gastrin.

    Zollinger–Ellison syndrome - Wikipedia

    en.wikipedia.org
    Do you have Zollinger-Ellison syndrome?
    If you have a first-degree relative, such as a sibling or parent, with MEN 1, it's more likely that you'll have Zollinger-Ellison syndrome. In this rare disease, tumors in the digestive tract cause excess production of a certain hormone. High levels of this hormone increase stomach acid, leading to peptic ulcers.

    Zollinger-Ellison syndrome - Symptoms and causes - Mayo Clinic

    mayoclinic.org
    How does Zollinger-Ellison syndrome affect the stomach?
    Gastrinomas produce large amounts of the hormone gastrin, which is what triggers your stomach to produce gastric acid. Too much gastrin leads to too much stomach acid, which can cause ulcers in your stomach and duodenum. ZES is also known as pancreatic ulcerogenic tumor syndrome. How does Zollinger-Ellison syndrome affect me?

    Zollinger-Ellison Syndrome - Cleveland Clinic

    my.clevelandclinic.org
    Can Zollinger-Ellison syndrome cause peptic ulcer disease?
    The extra stomach acid caused by Zollinger-Ellison syndrome can lead to peptic ulcer disease or GERD. Without treatment, these diseases can lead to complications such as The tumors that cause Zollinger-Ellison syndrome are sometimes cancerous and may spread to other parts of your body.

    Zollinger-Ellison Syndrome | NIDDK

    niddk.nih.gov
    What is Zollinger-Ellison syndrome (ZES)?
    They are characterized by gastric hypersecretion that results in peptic ulcers and diarrhea; this condition is known as Zollinger–Ellison syndrome (ZES). Recently, research studies have been conducted to seek new medical advances in relation to gastrinoma and Zollinger–Ellison syndrome.

    Gastrinoma - Wikipedia

    en.wikipedia.org
    Where does Zollinger-Ellison syndrome come from?
    They occasionally stem from other organs in the body, for example, the lymph nodes, stomach, liver, and ovaries. According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Zollinger-Ellison syndrome is rare.

    Zollinger-Ellison syndrome: Symptoms, diagnosis, and treatment

    medicalnewstoday.com
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  9. nih.gov
    https://www.niddk.nih.gov/health-infor…

    Zollinger-Ellison Syndrome - NIDDK

    Zollinger-Ellison syndrome is a condition that occurs when one or more tumors —called gastrinomas, which are located mainly in your pancreas or duodenum —cause your stomach to make too much acid.

  10. National Organization for Rare Disorders
    https://rarediseases.org/rare-diseases/…

    Zollinger-Ellison Syndrome - Symptoms, Causes, …

    Jan 9, 2019 · Learn about Zollinger-Ellison Syndrome, including symptoms, causes, and treatments. If you or a loved one is affected by this condition, visit NORD to find.

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  11. MedlinePlus
    https://medlineplus.gov/ency/article/000325.htm

    Zollinger-Ellison syndrome: MedlinePlus Medical Encyclopedia

  12. patient.info
    https://alpha30.patient.info/doctor/zollinger-ellison-syndrome

    Zollinger-Ellison Syndrome: Symptoms and Treatment

  13. Health
    https://www.health.com/zollinger-elliso…

    Zollinger-Ellison Syndrome: Symptoms, Causes, …

    Apr 2, 2024 · Zollinger-Ellison syndrome (ZES) is a digestive disorder that occurs when tumors called gastrinomas form in the pancreas or duodenum (the first part of the small intestine).

  14. UpToDate
    https://www.uptodate.com/contents/zollinger...

    Zollinger-Ellison syndrome (gastrinoma): Clinical ... - UpToDate

  15. Healthline
    https://www.healthline.com/health/zollinger-ellison-syndrome

    Zollinger-Ellison Syndrome: Symptoms, Treatment, and More

  16. mayoclinic.org
    https://www.akamai.mayoclinic.org/diseases...

    Zollinger-Ellison syndrome - Diagnosis and treatment - Mayo Clinic

  17. Osmosis
    https://www.osmosis.org/learn/Zollinger-Ellison_syndrome

    Zollinger-Ellison syndrome: Video, Causes, & Meaning - Osmosis

  18. Medical News Today
    https://www.medicalnewstoday.com/articles/186793

    Zollinger-Ellison syndrome: Symptoms, diagnosis, and treatment

  19. Wikiwand
    https://www.wikiwand.com/en/articles/Zollinger–Ellison_syndrome

    Zollinger–Ellison syndrome - Wikiwand

  20. BMJ Best Practice
    https://bestpractice.bmj.com/topics/en-gb/408

    Zollinger-Ellison syndrome - BMJ Best Practice

  21. Orphanet
    https://www.orpha.net/en/disease/detail/913

    Zollinger-Ellison syndrome - Orphanet

  22. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/sites/books/NBK537344

    Zollinger-Ellison Syndrome - StatPearls - NCBI Bookshelf