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  2. ATTR amyloidosis is a condition that causes abnormal deposits of a protein called amyloid in various organs. There are different subtypes of ATTR amyloidosis, but some common symptoms are1234:
    • Shortness of breath, especially with minimal exertion and when lying down
    • Leg and ankle swelling (edema)
    • Heart palpitations and arrhythmias, especially atrial fibrillation or flutter
    • Fatigue and weakness, especially in the legs
    • Weight loss and bloated stomach
    • Confusion or difficulty thinking
    • Coughing or wheezing, especially when lying down
    Learn more:
    The symptoms of ATTR vary based on the subtype but may include: weakness, especially in your legs leg and ankle swelling extreme fatigue insomnia heart palpitations (especially in ATTRwt)
    www.healthline.com/health/amyloidosis/attr-amyloi…

    Symptoms of transthyretin amyloidosis (ATTR-CM) are similar to heart failure symptoms, which include:

    • Shortness of breath (especially when lying down or doing minimal physical activity).
    • Bloated stomach.
    my.clevelandclinic.org/health/diseases/17855-amyl…
    Symptoms of wild-type ATTR amyloidosis result from stiffening of the heart due to amyloid deposits (restrictive cardiomyopathy). These symptoms may include: shortness of breath, sometimes just after mild exertion palpitations and abnormal heart rhythms, most frequently atrial fibrillation or atrial flutter leg swelling (oedema) weight loss
    www.amyloidosis.org.uk/about-amyloidosis/introdu…
    ATTR-CM symptoms are like those associated with heart failure. Shortness of breath is the most common, especially with minimal exertion and when lying down. Other symptoms usually occur after the shortness of breath is already there, including: Coughing or wheezing, especially when lying down. Swelling in the feet, ankles and legs
    www.heart.org/en/health-topics/cardiomyopathy/wh…
     
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  5. WEBATTR-CM is a heart condition caused by abnormal proteins that clump in the heart muscle and make it stiffer. Learn about the signs, diagnosis, and new treatments for this rare disease.