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- BARD1 displays a dual role in cancer development and progression as it acts as a tumor suppressor and an oncogene. Structurally, BARD1 has homologous domains to BRCA1 that aid their heterodimer interaction to inhibit the progression of different cancers such as breast and ovarian cancers following the BRCA1-dependant pathway.DOI: 10.1186/s12885-022-09567-4Publication: BMC Cancer. 2022; 22: 599.Published: 2022
www.ncbi.nlm.nih.gov/pmc/articles/PMC9161512/ - People also ask
BARD1 mystery: tumor suppressors are cancer susceptibility genes
- Published: 2022
- Authors: Yousef M. Hawsawi, Anwar Shams, Abdulrahma…
- DOI: 10.1186/s12885-022-09567-4
- Publication: BMC Cancer. 2022; 22: 599.
In recent decades, researchers have studied the role of the BARD1 (BRCA1-associated RING domain 1) gene in cancer progression and its usage as a prognostic biomarker for cancer and a potential candidate for targeted cancer therapy [1]. The human BARD1 gene is located in chromosome 2 (2q34–35) and co...New breast screening recommendations related to the BARD1 …
WEBRecent research has provided more evidence linking BARD1 and breast cancer risk, particularly for triple-negative (ER, PR, and HER-2) breast cancer. In light of this new …
BARD1 Gene Mutations: Risk, Management and Treatment
WEBJun 25, 2024 · Mutations in the BARD1 gene have been linked to increased risk for breast cancer in women (people assigned female at birth). Currently, it is not believed that …
About Mutations in the BARD1 Gene - Memorial Sloan Kettering …
WEBJul 17, 2023 · A BARD1 mutation may increase your risk for breast cancer. More research is needed for us to better understand this risk. While a BARD1 mutation means you have a …
Literature Review of BARD1 as a Cancer Predisposing Gene with …
WEBJul 27, 2020 · We selected peer reviewed research articles that focused on three themes: (i) sequence analyses of BARD1 to identify potentially pathogenic germline variants in adult …
BARD1 is a Low/Moderate Breast Cancer Risk Gene: Evidence …
WEBMay 28, 2019 · In this large case-control study, we provided strong evidence that BARD1 is a low/moderate cancer susceptibility gene. The large collection of BC cases and controls …
The antitumorigenic roles of BRCA1–BARD1 in DNA …
WEBFeb 24, 2020 · The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA double-strand break (DSB) repair by homologous recombination and protects DNA replication...
BARD1 and Breast Cancer: The Possibility of Creating Screening …
WEBOct 24, 2020 · Analyzing structure and functions of the BARD1 gene, we believe that BARD1 gene can play an important role in the pathogenesis of breast cancer and in the …
Gene Mutation BARD1 and Cancer Risk - Everyday …
WEBSep 20, 2022 · Women who carry mutations in the BARD1 gene may be more likely to develop breast cancer and possibly ovarian cancer. Here’s what you need to know about this cancer risk gene.
Summary of BARD1 Mutations and Precise Estimation of Breast …
WEBJul 15, 2020 · Over the last two decades, numerous BARD1 mutations/pathogenic variants (PVs) have been found in patients with breast cancer (BC) and ovarian cancer (OC). …
Cancer Risk Management for People with a BARD1 Mutation
WEBSep 19, 2024 · People with an inherited mutation in the BARD1 gene have options for managing their cancer risk. Learn about the risk-management guidelines. FORCE is …
BARD1 mystery: tumor suppressors are cancer susceptibility genes
WEBJun 1, 2022 · The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa protein. BARD1 displays a dual role in cancer development and progression as it …
BARD1 mystery: tumor suppressors are cancer susceptibility genes
WEBJun 2, 2022 · The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa protein. BARD1 displays a dual role in cancer development and progression as it …
Cancer Risk in People with an Inherited BARD1 Mutation
WEBSep 19, 2024 · Women with a BARD1 mutation have an increased risk of breast cancer. The estimated lifetime risk of breast cancer is 17 - 30 percent. Currently, there is not enough …
BARD1 Mutation - My Cancer Genome
WEBBARD1 Mutation is present in 1.28% of AACR GENIE cases, with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive …
Functional Analysis of BARD1 Missense Variants on …
WEB4 days ago · Women with germline BRCA1 mutations face an increased risk of developing breast and ovarian cancers. BARD1 (BRCA1 associated RING domain 1) is an essential …
BARD1 is A Low/Moderate Breast Cancer Risk Gene: Evidence …
WEBMay 28, 2019 · BARD1 is a potentially predisposing BC gene, however, the rarity of its mutations and an insufficient family/study size have hampered corroboration and …
BARD1 deletion in a patient with suspected hereditary colorectal …
WEBMar 15, 2024 · Deleterious germline variants in the BRCA1-associated ring domain (BARD1) gene moderately elevate breast cancer risk; however, their potential association with …
Literature Review of BARD1 as a Cancer Predisposing Gene with …
WEBJul 27, 2020 · Here, we review studies of BARD1 as a cancer predisposing gene and illustrate the challenge of discovering additional cancer risk genes for hereditary breast …
Summary of BARD1 Mutations and Precise Estimation of Breast …
WEBJul 15, 2020 · Over the last two decades, numerous BARD1 mutations/pathogenic variants (PVs) have been found in patients with breast cancer (BC) and ovarian cancer (OC). …
The Effects of Genetic and Epigenetic Alterations of BARD1 on …
WEBJul 21, 2020 · A novel mutation in the BARD1 gene was discovered in a patient who had 5 family members with PDAC but no other cancer types. BARD1 c.632T > A (p.Leu211*) …
Cancer Treatment in People with a BARD1 Mutation
WEBJun 21, 2024 · The PARP inhibitor, Lynparza (olaparib) has FDA-approval to treat metastatic, castration-resistant prostate cancer in people who have a mutation in BARD1 …
BARD1 and Breast Cancer: The Possibility of Creating Screening …
WEBOct 24, 2020 · The BARD1 and BRCA1 (BReast CAncer type 1) proteins have similar structures and functions, and they combine to form the new molecule BARD1-BRCA1 …
BARD1 BRCA1 associated RING domain 1 [ (human)] - National …
WEBSep 19, 2024 · This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have …
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