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    Ceruloplasmin - Wikipedia

    Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948. Another protein, hephaestin, is noted for its homology to … See more

    Ceruloplasmin (CP) is an enzyme (EC 1.16.3.1) synthesized in the liver containing 6 atoms of copper in its structure. Ceruloplasmin carries more than 95% of the total copper in healthy human plasma. The rest is … See more

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    A cis-regulatory element called the GAIT element is involved in the selective translational silencing of the Ceruloplasmin transcript. The … See more

    • Hellman NE, Gitlin JD (2002). "Ceruloplasmin metabolism and function". Annual Review of Nutrition. 22: 439–58. doi: See more

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    Active site structure image

    The multicopper active site of CP contains a type I (T1) mononuclear copper site and a trinuclear copper center ~ 12-13 Šaway (see figure 2). The tricopper center consists of two type III (T3) coppers and one type II (T2) copper ion. The two T3 copper ions are … See more

    Like any other plasma protein, levels drop in patients with hepatic disease due to reduced synthesizing capabilities.
    Mechanisms of low ceruloplasmin levels:
    • Gene … See more

    • GeneReviews/NCBI/NIH/UW entry on Aceruloplasminemia
    • OMIM entries on Aceruloplasminemia
    • Overview of all the structural information available in the See more

     
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  3. Biochemistry, Ceruloplasmin - StatPearls - NCBI …

    WEBFeb 24, 2023 · Ceruloplasmin is a serum ferroxidase responsible for 95% copper transport in the blood. It is well known for its role in the …

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