chaperone system in humans - Search
  1. Nature
    https://www.nature.com/articles/s41467-021-22369-9

    The landscape of molecular chaperones across human tissues

    • Chaperones are highly conserved molecular machines that control cellular protein homeostasis (proteostasis). Across species, they promote de novo protein folding and protein maturation1, protein tr… See more

    Abstract

    The sensitivity of the protein-folding environment to chaperone disruption can be highly tissue-specific. Yet, the organization of the chaperone system across phy… See more

    Nature
    Results

    Chaperones are ubiquitously and highly expressed across human tissues
    We … See more

    Nature
    Discussion

    Chaperones are basic components of all living organisms, and are thus commonly regarded as house-keeping genes1. But, are all folding environments similar to each other? In a … See more

    Nature
    Methods

    Curation of an integrated list of human chaperones
    We compiled a curated list of 195 known human chaperone, co-chaperone, and folding enz… See more

    Nature
    Code availability

    Data of chaperones analyzed in the study are available as Supplementary Data 1. Data of tissues analyzed in the study appear in Supplementary Data 2. Data of disease-as… See more

    Nature
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  2. The chaperone (or chaperoning) system (CS) constitutes molecular chaperones, co-chaperones, and chaperone co-factors, interactors and receptors, and its canonical role is protein quality control. A malfunction of the CS may cause diseases, known as the chaperonopathies.

    The Neurochaperonopathies: Anomalies of the Chaperone Syste…

    www.mdpi.com/2076-3417/11/3/898
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  3. People also ask
    What is a chaperone system?
    Through computational analyses of large-scale tissue transcriptomes, we unveil that the chaperone system is composed of core elements that are uniformly expressed across tissues, and variable elements that are differentially expressed to fit with tissue-specific requirements.

    The landscape of molecular chaperones across human tissues reveals a

    nature.com
    What phenotypes are found in the human chaperone system?
    Here, the authors show that the human chaperone system consists of ubiquitous core chaperones and tissue-specific variable chaperones, perturbation of which leads to tissue-specific phenotypes. Chaperones are highly conserved molecular machines that control cellular protein homeostasis (proteostasis).

    The landscape of molecular chaperones across human tissues reveals a

    ncbi.nlm.nih.gov
    How does chaperonenet work?
    Users can query ChaperoneNet by chaperone and tissue, and obtain a graphical network representation of the functional relationships of the query chaperone in that tissue. The network highlights core chaperones, marks chaperone families, and reports known disease associations.

    The landscape of molecular chaperones across human tissues reveals a

    nature.com
    What are molecular chaperones?
    In molecular biology, molecular chaperones are proteins that assist the conformational folding or unfolding of large proteins or macromolecular protein complexes. There are a number of classes of molecular chaperones, all of which function to assist large proteins in proper protein folding during or after synthesis, and after partial denaturation.

    Chaperone (protein) - Wikipedia

    en.wikipedia.org
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  4. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042005

    The landscape of molecular chaperones across human tissues …

     
  5. Wikipedia
    https://en.wikipedia.org/wiki/Chaperone_(protein)

    Chaperone (protein) - Wikipedia

  6. Cell Press
    https://www.cell.com/trends/genetics/fullte…

    Unfolding the role of chaperones and chaperonins in …

    We then summarize contemporary research concerning the role of these proteins in several human diseases, concentrating on the genes coding for chaperone and chaperonin proteins and the importance of chaperones in …

  7. The New England Journal of Medicine
    https://www.nejm.org/doi/full/10.1056/NEJ…

    Sick Chaperones, Cellular Stress, and Disease | NEJM

    Oct 6, 2005 · Cells maintain a complete set of functionally competent proteins normally and in the face of injury or stress with the use of various mechanisms, including systems of proteins called molecular...

  8. Images of Chaperon systems in human

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  9. Nature
    https://www.nature.com/articles/nature10317

    Molecular chaperones in protein folding and proteostasis | Nature

  10. PubMed
    https://pubmed.ncbi.nlm.nih.gov/33846299

    The landscape of molecular chaperones across human tissues

  11. bioRxiv
    https://www.biorxiv.org/content/10.1101/2020.03.04.976720v1.full.pdf
    [PDF]

    The landscape of molecular chaperones across human …

  12. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0168952501024131

    Unfolding the role of chaperones and chaperonins in human disease

  13. MDPI
    https://www.mdpi.com/2076-3417/11/3/…

    The Neurochaperonopathies: Anomalies of the …

    Jan 20, 2021 · The chaperone (or chaperoning) system (CS) constitutes molecular chaperones, co-chaperones, and chaperone co-factors, interactors and receptors, and its canonical role is protein quality control. A malfunction of the …

  14. Springer
    https://link.springer.com/chapter/10.1007/978-94-007-4667-1_2

    Chaperones: General Characteristics and Classifications

  15. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893670

    Mitochondrial Chaperone in human health and diseases - PMC

  16. Nature
    https://www.nature.com/articles/s41467-021-22369-9.pdf
    [PDF]

    The landscape of molecular chaperones across human …

  17. Cell Press
    https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(21)00227-0

    Chaperone networks are shaped by cellular differentiation and …

  18. Nature
    https://www.nature.com/articles/s41580-019-0133-3

    The Hsp70 chaperone network | Nature Reviews Molecular Cell …

  19. PubMed
    https://pubmed.ncbi.nlm.nih.gov/11525836

    Unfolding the role of chaperones and chaperonins in human disease

  20. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773841

    Hsp70 chaperones: Cellular functions and molecular mechanism

  21. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0891584921008121

    Mitochondrial chaperones in human health and disease

  22. ScienceDirect
    https://www.sciencedirect.com/science/article/abs/...

    Unfolding the role of chaperones and chaperonins in human disease

  23. Springer
    https://link.springer.com/article/10.1007/s10735-023-10119-8

    The chaperone system in cancer therapies: Hsp90 - Springer

  24. PubMed
    https://pubmed.ncbi.nlm.nih.gov/36933095

    The chaperone system in cancer therapies: Hsp90 - PubMed

  25. Nature
    https://www.nature.com/articles/gim20052

    Genetic disorders involving molecular-chaperone genes: A

  26. University of Arkansas
    https://news.uark.edu/articles/71073

    Unique Chicken Line Advances Research on Autoimmune …