diseases caused by protein aggregation - Search
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  1. Nature
    https://www.nature.com/articles/nrd3050

    Protein aggregation diseases: pathogenicity and therapeutic ...

    • •Amyloids can be broadly defined as insoluble protein aggregates containing a characteristic highly ordered, β-sheet-rich structural motif. The latter can be identified histologically with dyes such as Congo … See more

    Abstract

    A growing number of diseases seem to be associated with inappropriate deposition of protein aggregates. Some of these diseases — such as Alzheimer's disease and system… See more

    Nature
    Main

    Inappropriate aggregation of proteins is normally prevented by complex cellular quality … See more

    Nature
    Acknowledgements

    Stained sections from human Alzheimer's diseased brains, prion-diseased brains, kidney amyloidosis, and the PrPSc histoblot were provided courtesy of J. Haybaeck, H. Fischer, V. … See more

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    Authors and Affiliations
    Institute of Neuropathology, University Hospital of Zürich, Schmelzbergstrasse 12, Zürich, CH8091, Switzerland Adriano Aguzzi & Tracy O'… See more

    Nature
    Glossary

    Blood–brain barrier
    A protective wall of capillary epithelium separating the brain parenchyma from the bloodstream that is impenetrable to most circulating … See more

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  2. Diabetes, Alzheimer’s disease, Parkinson’s disease
    More than 20 unique diseases such as diabetes, Alzheimer’s disease, Parkinson’s disease are caused by the abnormal aggregations of pathogenic proteins such as amylin, β-amyloid (Aβ), and α-synuclein.
    Author: Sungmun Lee, Myung Chul Choi, Kenana Al Adem, Suryani Lukman, Tae-Yeon Kim
    Publish Year: 2020

    Aggregation and Cellular Toxicity of Pathogenic or Non-pathogeni…

    www.nature.com/articles/s41598-020-62062-3
    www.nature.com/articles/s41598-020-62062-3
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  3. People also ask
    Can protein aggregation cause systemic diseases?
    Apart from NDDs, protein aggregation can associate with systemic diseases also. Systemic diseases affect the entire body as opposed to just one organ. Different types of systemic diseases that are caused by misfolding of proteins are discussed below. 7.1. Proteins aggregated in liver diseases

    A comprehensive review of protein misfolding disorders, underlying

    sciencedirect.com
    What are the effects of consuming too much protein?

    Livia Dickson Chen

    PhD in Nutrition · 11 years of exp

    Excessive protein consumption is mainly related to kidney failure, irritability, liver problems and weight gain. Protein supplementation should be done based on the calculation taking into account the individual's weight, without extrapolating the recommendations.
    Q&A: Protein
    bing.com
    Which protein misfolding diseases involve aggregation of protein?
    Most of the protein misfolding diseases (PMDs) involve aggregation of protein. We have discussed such proteins like Aβ peptide, α-synuclein, amylin and lysozyme involved in Alzheimer's, Parkinson's, type II diabetes and non-neuropathic systemic amyloidosis respectively.

    Protein misfolding and related human diseases: A comprehensive review

    sciencedirect.com
    What causes protein aggregation in neurodegenerative diseases?
    Authors to whom correspondence should be addressed. The accumulation of protein aggregates is the hallmark of many neurodegenerative diseases. The dysregulation of protein homeostasis (or proteostasis) caused by acute proteotoxic stresses or chronic expression of mutant proteins can lead to protein aggregation.

    IJMS | Free Full-Text | Cellular Protein Aggregates: Formation ... - MDPI

    mdpi.com
    What diseases are associated with inappropriate deposition of protein aggregates?
    A growing number of diseases seem to be associated with inappropriate deposition of protein aggregates. Some of these diseases — such as Alzheimer's disease and systemic amyloidoses — have been recognized for a long time.

    Protein aggregation diseases: pathogenicity and therapeutic

    nature.com
    What causes toxicity associated with protein aggregation?
    Mechanism of toxicity associated with aggregated proteins The dynamic nature of protein aggregation involves the formation of transient intermediate structures, dissolution of mature fibrils etc., makes it challenging to uncover the real culprit of the toxicity associated with aggregation.

    Protein aggregation: Consequences, mechanism, characterization and

    sciencedirect.com
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  4. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S1568163723001769

    A comprehensive review of protein misfolding disorders, …

     
  5. Nature
    https://www.nature.com/scitable/topicpage/protein...

    Protein Misfolding and Degenerative Diseases | Learn Science

  6. Nature
    https://www.nature.com/articles/s41580-023-00647-2

    Mechanisms and pathology of protein misfolding and aggregation

  7. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/books/NBK208522

    Protein Aggregation - Neurodegeneration - NCBI Bookshelf

  8. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC10273386

    Big versus small: The impact of aggregate size in disease

  9. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0141813022025806

    Protein misfolding and related human diseases: A comprehensive …

  10. PubMed
    https://pubmed.ncbi.nlm.nih.gov/20190788

    Protein aggregation diseases: pathogenicity and therapeutic ...

  11. Science | AAAS
    https://www.science.org/content/blog-post/protein-aggregation-diseases

    Protein Aggregation Diseases - Science | AAAS

  12. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC5348787

    Protein misfolding in neurodegenerative diseases: implications …

  13. Nature
    https://www.nature.com/articles/s41598-020-62062-3

    Aggregation and Cellular Toxicity of Pathogenic or Non …

  14. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0141813023020172

    Protein aggregation: Consequences, mechanism, …

  15. PubMed
    https://pubmed.ncbi.nlm.nih.gov/36356861

    Protein misfolding and related human diseases: A comprehensive …

  16. MDPI
    https://www.mdpi.com/1422-0067/24/10/8593

    Cellular Protein Aggregates: Formation, Biological Effects, and

  17. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6432913

    Protein misfolding, aggregation, and conformational strains in ...

  18. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC11157337

    Protein aggregation and therapeutic strategies in SOD1- and TDP …

  19. Wiley Online Library
    https://onlinelibrary.wiley.com/doi/10.1111/jnc.15955

    Protein aggregation: A detrimental symptom or an adaptation …

  20. Nature
    https://www.nature.com/articles/s41576-018-0011-4

    Prions, prionoids and protein misfolding disorders - Nature

  21. PubMed
    https://pubmed.ncbi.nlm.nih.gov/16610361

    Protein aggregation as a cause for disease - PubMed

  22. Nature
    https://www.nature.com/articles/s41593-018-0235-9

    Protein misfolding, aggregation, and conformational strains in ...

  23. News-Medical.net
    https://www.news-medical.net/news/20241103/Hunting...

    Huntington’s disease symptoms reduced by new peptide-polymer …

  24. Translational Neurodegeneration
    https://translationalneurodegeneration.biomedcentral.com/...

    Protein misfolding in neurodegenerative diseases: implications …