dna methyltransferase family - Search
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  1. Copilot Answer
    SymbolDNA_methylase
    Pfam clanCL0063
    InterProIPR001525
    Classification

    MTases can be divided into three different groups on the basis of the chemical reactions they catalyze:
    • m6A - those that generate N6-methyladenine EC 2.1.1.72
    • m4C - those that generate … See more

    Mammalian

    At least four differently active DNA methyltransferases have been identified in mammals. They are named DNMT1, two isoforms transcribed from the DNMT3a gene: DNMT3a1 and DNMT3a2, and DNMT3b. … See more

    Clinical significance

    Because of the epigenetic effects of the DNMT family, some DNMT inhibitors are under investigation for treatment of some cancers:
    • Vidaza (azacitidine) in phase III trials for myelodyspl… See more

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