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  2. Initiation of DNA replication in prokaryotes involves the following steps1234:
    1. Unwinding of DNA at the origin of replication by enzymes like DnaA and DnaB helicase.
    2. Formation of two replication forks that move in opposite directions.
    3. Continuous replication of the leading strand, while the lagging strand is replicated discontinuously in short segments called Okazaki fragments.
    4. Recognition of the origin of replication, which is approximately 245 base pairs long and rich in AT sequences.
    5. Helicase unwinding the DNA by breaking the hydrogen bonds between the nitrogenous base pairs.
    Learn more:
    DNA replication in prokaryotes begins with the unwinding of DNA at the origin of replication by enzymes like DnaA and DnaB helicase. This produces two replication forks that move in opposite directions. The leading strand is replicated continuously while the lagging strand is replicated discontinuously in short segments called Okazaki fragments.
    www.slideshare.net/slideshow/prokaryotic-dna-repli…
    DNA replication begins at a specific spot on the DNA molecule called the origin of replication. At the origin, enzymes unwind the double helix making its components accessible for replication. The helix is unwound by helicase to form a pair of replication forks. The unwound helix is stabilized by SSB proteins and DNA topoisomerases.
    microbenotes.com/prokaryotic-dna-replication-enzy…
    The DNA replication in prokaryotes takes place in the following place: The two strands of DNA unwind at the origin of replication. Helicase opens the DNA and replication forks are formed. The DNA is coated by the single-strand binding proteins around the replication fork to prevent rewinding of DNA.
    byjus.com/biology/dna-replication-machinery-enzy…
    The origin of replication is approximately 245 base pairs long and is rich in AT sequences. This sequence of base pairs is recognized by certain proteins that bind to this site. An enzyme called helicase unwinds the DNA by breaking the hydrogen bonds between the nitrogenous base pairs.
    openoregon.pressbooks.pub/mhccmajorsbio/chapt…
     
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    Aug 30, 2022 · Prokaryotic DNA replication is often studied in the model organism coli, but all other prokaryotes show many similarities. Replication is bi-directional and originates at a single origin of replication (OriC). Takes place in the cell …

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    Aug 17, 2019 · DnaA proteins bind regions in oriC throughout the cell cycle, but to initiate replication, DnaA proteins must bind a few particular oriC sequences. The presence of DnaA at these sites recruits a helicase (usually DnaB helicase) to …

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    May 17, 2021 · DNA replication can be divided into three stages: initiation, elongation, and termination. How does the replication machinery know where to begin? It turns out that there are specific nucleotide sequences called origins …

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    Sep 22, 2024 · The process of DNA replication can be summarized as follows: DNA unwinds at the origin of replication. Helicase opens up the DNA-forming replication forks; these are extended bidirectionally. Single-strand binding …

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    Nov 23, 2024 · In prokaryotes, three main types of polymerases are known: DNA pol I, DNA pol II, and DNA pol III. DNA pol III is the enzyme required for DNA synthesis; DNA pol I and DNA pol II are primarily required for repair. There are …

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