DeLuise was born in Brooklyn, New York, to Italian American parents Vincenza "Jennie" (née DeStefano), a homemaker, and John DeLuise, a public employee (garbage collector). He was the youngest of three children, ha… See more

DeLuise's paid stage debut, at age 18, of Bernie the dog was in the drama Bernie's Christmas Wish. His first steady gig was as an intern at the Cleveland Play House, 1952–54, as stage manager and actor.
In 1961, De… See more

In 1964, while working in a summer theater in Provincetown, Massachusetts, DeLuise met actress Carol Arthur. They married in 1965 and had three sons, all of whom became actors, writers, and directors themselves: … See more