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    Estrone is a medication and naturally occurring steroid hormone. It is used in menopausal hormone therapy and for other indications. Estrone is a hormone that all adults make naturally. It is a far less potent estrogen than estradiol and is a relatively weak estrogen. Estrone is naturally derived from the peripheral conversion of androstenedione by an aromatase enzyme found in adipose tissues and is converted to estradiol in peripheral tissues.

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