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  1. Nature
    https://www.nature.com › articles

    The Fanconi anaemia/BRCA pathway | Nature Reviews Cancer

    • •Fanconi anaemia (FA) is an autosomal recessive disease that is characterized by developmental abnormalities, cancer susceptibility and cellular sensitivity to crosslinking agents.… See more

    Abstract

    Fanconi anaemia (FA) is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA cro… See more

    Nature
    Main

    Fanconi anaemia (FA) is a rare autosomal recessive disease that is characterized by … See more

    Nature
    Acknowledgements

    We apologize to those authors whose work is not cited owing to space constraints. A.D.D. is a Doris Duke Distinguished Clinical Scientist and is supported by National In… See more

    Nature
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    Authors and Affiliations
    Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, 02115, Massachus… See more

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  2. Studies of fa brca pathway
    National Center for Biotechnology Information
    The Fanconi Anemia Pathway in Cancer
    Cells are constantly subjected to genomic insults from exogenous and endogenous sources. Cells are equipped with multiple specialized DNA repair mechanisms for detecting and repairing specific DNA damage lesions. Eradicating DNA damage is essential to the maintenance of genomic integrity. Unfaithful...
    Author: Joshi Niraj, An…
    Published: 2019/03
    DOI: 10.1146/annurev-c…
    National Center for Biotechnology Information
    The Fanconi Anemia/BRCA Pathway: FANCD2 at the Crossroad between Repair and Checkpoint Responses to DNA Damage
    In 1967 a Swiss physician, Guido Fanconi, reported his observations of a recessively inherited aplastic anemia in two brothers along with several other physical malformations.1 Fanconi anemia (FA) is a rare syndrome characterized by progressive pancytopenia, increased spontaneous and mutagen-induced...
    Author: Massimo Bogli…
    Published: 2013
    Affiliations: * Correspo…
    National Center for Biotechnology Information
    Fanconi Anemia Pathway: Mechanisms of Breast Cancer Predisposition Development and Potential Therapeutic Targets
    The maintenance of genomic stability is crucial for species survival, and its failure is closely associated with tumorigenesis. The Fanconi anemia (FA) pathway, involving 22 identified genes, plays a central role in repairing DNA interstrand cross-links. Importantly, a germline defect in any of thes...
    Author: Can-Bin Fang…
    Published: 2020
    Publication: Front Cel…
    PubMed
    The Fanconi anaemia/BRCA pathway
    Fanconi anaemia (FA) is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking agents. Seven FA-associated genes have recently been cloned, and their products were found to interact with well-k...
    Author: Alan D D&#x2…
    Published: 2003/1
    Keywords: National In…
    ScienceDirect
    Review Article The Fanconi anemia/BRCA pathway: A coordinator of cross-link repair
    Fanconi anemia (FA) is a rare inherited disease characterized by genomic instability and markedly increased cancer risk. Efforts to elucidate the molecular basis of FA have unearthed a novel DNA damage response pathway, the integrity of which is critical for cellular resistance to DNA cross-linking ...
    Published: 2006/08/15
    Cited By: 0
    Keywords: Fanconi an…
    National Center for Biotechnology Information
    BRCA-FA pathway as a target for anti-tumor drugs
    Promising research on DNA repair signaling pathways predicts a new age of anti-tumor drugs. This research was initiated through the discovery and characterization of proteins that functioned together in signaling pathways to sense, respond, and repair DNA damage. It was realized that tumor cells oft...
    Author: Rachel Litman…
    Published: 2008/05
    DOI: 10.2174/18715200…
    PubMed
    New roads to FA/BRCA pathway: H2AX
    We have recently described an involvement of H2AX into the Fanconi anemia (FA) BRCA pathway through recruitment of FA protein FANCD2 to the sites of stalled replication forks. We showed that BRCA1 mediates the recruitment of FANCD2 by gammaH2AX to damaged chromatin and cells deficient or depleted of...
    Author: Alex Lyakhovich
    Published: 2007/05/02
    Keywords: National In…
    PubMed
    A Boolean network model of the FA/BRCA pathway
    Motivation: Fanconi anemia (FA) is a chromosomal instability syndrome originated by inherited mutations that impair the Fanconi Anemia/Breast Cancer (FA/BRCA) pathway, which is committed to the repair of DNA interstrand cross-links (ICLs). The disease displays increased spontaneous chromosomal aberr...
    Author: Alfredo Rodríg…
    Published: 2012/03/15
    Keywords: Fanconi an…
     
  3. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    The Fanconi Anemia Pathway in Cancer - PMC - National Center …

     
  4. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › books

    The Fanconi Anemia/BRCA Pathway: FANCD2 at the …

    WEBAt least eleven genes are involved in Fanconi anemia, including the breast cancer susceptibility gene BRCA2. Six of the Fanconi anemia proteins (FANCA, C, E, F, G and L) assemble in a complex that is required for …

  5. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Fanconi Anemia Pathway: Mechanisms of Breast Cancer …

  6. Nature
    https://www.nature.com › articles

    The Fanconi anaemia pathway: new players and new functions

  7. Cell Press
    https://www.cell.com › current-biology › full…

    Fanconi anemia pathway: Current Biology - Cell Press

    WEBSep 25, 2017 · The FA pathway ensures fidelity in the repair of the ICL-derived double-strand break by blocking the error-prone non-homologous end-joining pathway and funneling the ICL-derived double-strand break …

  8. Frontiers
    https://www.frontiersin.org › journals › c…

    Frontiers | Fanconi Anemia Pathway: Mechanisms of …

    WEBApr 1, 2020 · The FA pathway, also called the FA-BRCA pathway, is a fundamental DNA repair pathway that recognizes DNA damage and orchestrates DNA damage responses, especially for DNA interstrand …

  9. Nature
    https://www.nature.com › articles

    Beyond DNA repair and chromosome instability—Fanconi …

  10. Cell Press
    https://www.cell.com › molecular-cell › fulltext

    The splicing factor CCAR1 regulates the Fanconi anemia/BRCA …

  11. Genes & Development
    https://genesdev.cshlp.org › content
    [PDF]

    The Fanconi Anemia/BRCA pathway: new faces in the crowd

  12. Springer
    https://link.springer.com › article

    Fanconi anemia pathway and its relationship with cancer

    WEBJun 5, 2021 · In cervical cancer (CC), hypermethylation of BRCA1 and FANCF co-excist in patient samples, suggesting an attenuating function of FA pathway in CC (Narayan et al., 2004). In sporadic breast cancer, …

  13. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    The Fanconi anaemia/BRCA pathway - PubMed

  14. Cell Press
    https://www.cell.com › cell-reports › fulltext

    NEIL3 contributes to the Fanconi anemia/BRCA pathway by

  15. ScienceDirect
    https://www.sciencedirect.com › science › article › pii

    The Fanconi anemia/BRCA pathway: A coordinator of cross-link …

  16. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    BRCA-FA pathway as a target for anti-tumor drugs - PMC

  17. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    New roads to FA/BRCA pathway: H2AX - PubMed

  18. Nature
    https://www.nature.com › articles

    Histone-methyltransferase KMT2D deficiency impairs the Fanconi …

  19. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    A Boolean network model of the FA/BRCA pathway - PubMed

  20. ScienceDirect
    https://www.sciencedirect.com › science › article › pii

    NEIL3 contributes to the Fanconi anemia/BRCA pathway by …

  21. Academia.edu
    https://www.academia.edu › A_Boolean...

    A Boolean network model of the FA/BRCA pathway - Academia.edu