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  1. Wikipedia
    https://en.wikipedia.org/wiki/FANCD2

    FANCD2 | Wikipedia

    • Fanconi anemia group D2 protein is a protein that in humans is encoded by the FANCD2 gene. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2 (this gene), FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, FANCN and FANCO. Fanconi anemia … See more

    AliasesFANCD2, FA-D2, FA4, FACD, FAD, FAD2, FANCD, Fanconi anemia complementation group D2, FA complementation group D2
    External IDsOMIM: 613984; MGI: 2448480; HomoloGene: 13212; GeneCards: FANCD2; OMA:FANCD2 - orthologs
    Function

    Fanconi anemia is a disorder with a recessive Mendelian pattern of inheritance characterized by chromosomal instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective … See more

    Infertility

    Humans with a FANCD deficiency display hypogonadism, male infertility, impaired spermatogenesis, and reduced female fertility. Similarly, mice deficient in FANCD2 show hypogonadism, impaired fertility and impaired g… See more

    FANCD2–FANCI is a clamp stabilized on DNA by ... | Nature
    Nature
    Clinical significance

    Tobacco smoke suppresses the expression of FANCD2, which codes for a DNA damage "caretaker" or repair mechanism.
    FANCD2 mutant mice have a significantly increased incidence of tumors including ovarian, ga… See more

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  2. GeneCards
    https://www.genecards.org/cgi-bin/carddisp.pl?gene=FANCD2

    FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody

     
  3. Nature
    https://www.nature.com/articles/s41594-0…

    FANCD2–FANCI is a clamp stabilized on DNA by

    WEBFeb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that …

    • Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
    • Publish Year: 2020
  4. Studies of fancd2
    PubMed
    FANCD2 and DNA Damage - PubMed
    Investigators have dedicated considerable effort to understanding the molecular basis underlying Fanconi Anemia (FA), a rare human genetic disease featuring an extremely high incidence of cancer and many congenital defects. Among those studies, FA group
    Author: Manoj Nepal
    Published: 2017/08/19
    Keywords: DNA dama…
    National Center for Biotechnology Information
    The Fanconi Anemia/BRCA Pathway: FANCD2 at the Crossroad between Repair and Checkpoint Responses to DNA Damage
    In 1967 a Swiss physician, Guido Fanconi, reported his observations of a recessively inherited aplastic anemia in two brothers along with several other physical malformations.1 Fanconi anemia (FA) is a rare syndrome characterized by progressive pancytopenia,
    Author: Massimo Bogli…
    Published: 2013
    Affiliations: * Correspo…
    National Center for Biotechnology Information
    FANCD2 and DNA Damage - PMC - National Center for Biotechnology Information
    Investigators have dedicated considerable effort to understanding the molecular basis underlying Fanconi Anemia (FA), a rare human genetic disease featuring an extremely high incidence of cancer and many congenital defects. Among those studies, FA group
    Author: Manoj Nepal, …
    Published: 2017/08
    Publication: Int J Mol …
    PubMed
    Mechanism, specificity, and function of FANCD2-FANCI ubiquitination and deubiquitination
    Fanconi anemia (FA) is a rare genetic disorder caused by mutations in any of the currently 22 known FA genes. The products of these genes, along with other FA-associated proteins, participate in a biochemical pathway, known as the FA pathway. This pathway
    Author: Kimon Lemonidis
    Published: 2022/8
    Keywords: DNA repair…
    PubMed
    Subcellular localization of FANCD2 is associated with survival in ovarian carcinoma
    Objective: Ovarian cancer is a leading cause of death from gynecological cancers. Late diagnosis and resistance to therapy results in mortality and effective screening is required for early diagnosis and better treatments. Expression of the Fanconi Anemia
    Author: Sonali Joshi
    Published: 2020/02/25
    Keywords: Ovarian ca…
    National Center for Biotechnology Information
    FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress
    REV1 is a eukaryotic member of the Y-family of DNA polymerases involved in translesion DNA synthesis and genome mutagenesis. Recently, REV1 is also found to function in homologous recombination. However, it remains unclear how REV1 is recruited to the
    Author: Yeran Yang, Z…
    Published: 2015/09/09
    Publication: Nucleic A…
    PubMed
    The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export
    Fanconi anemia (FA) is characterized by congenital abnormalities, bone marrow failure, and cancer susceptibility. The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink
    Author: Anne Olazaba…
    Published: 2024 Jan
    Keywords: CP: Molecu…
    National Center for Biotechnology Information
    Monoubiquitinated Fanconi Anemia D2 (FANCD2-Ub) Is Required for BCR-ABL1 Kinase -Induced Leukemogenesis
    Fanconi D2 (FANCD2) is monoubiquitinated on K561 (FANCD2-Ub) in response to DNA double-strand breaks (DSBs) to stimulate repair of these potentially lethal DNA lesions. FANCD2-Ub was upregulated in CD34+ chronic myeloid leukemia (CML) cells and in BCR-ABL1
    Author: Mateusz Kopty…
    Published: 2011/08
    DOI: 10.1038/leu.2011.91
    National Center for Biotechnology Information
    Ferroptosis regulator FANCD2 is associated with immune infiltration and predicts worse prognosis in lung adenocarcinoma
    Lung adenocarcinoma (LUAD) remains one of the leading causes of cancer-related death. Although immunotherapy has been shown to improve survival in LUAD patients, only a select group of LUAD patients could benefit from it. The correlation between ferroptosis
    Author: Chenyang Ye, …
    Published: 2022
    Publication: Front Gen…
  5. Nature
    https://www.nature.com/articles/s41586-024-07770-w

    FANCD2–FANCI surveys DNA and recognizes double- to single …

  6. PubMed
    https://pubmed.ncbi.nlm.nih.gov/28825622

    FANCD2 and DNA Damage | PubMed

  7. Nature
    https://www.nature.com/articles/s42003-021-01647-8

    FANCD2 modulates the mitochondrial stress response to prevent …

  8. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/gene/2177

    FANCD2 FA complementation group D2 [ (human)] | National …

  9. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/books/NBK6087

    The Fanconi Anemia/BRCA Pathway: FANCD2 at the …

    WEBAvailable data indicate that FANCD2 is involved in cell cycle regulation and DNA repair. Our current knowledge on the functional significance of FA pathway and more specifically FANCD2 and its interacting proteins in …

  10. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578191

    FANCD2 and DNA Damage - PMC | National Center for …

  11. Cell Press
    https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01622-4

    The FANCI/FANCD2 complex links DNA damage response to R …

  12. PubMed
    https://pubmed.ncbi.nlm.nih.gov/34137174

    Mechanism, specificity, and function of FANCD2-FANCI ... | PubMed

  13. Nature
    https://www.nature.com/articles/s41594-021-00602-9

    Fanconi anemia proteins participate in a break-induced ... | Nature

  14. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Term=2177

    FANCD2 FA complementation group D2 [ Homo sapiens (human) ]

  15. PubMed
    https://pubmed.ncbi.nlm.nih.gov/32165999

    Subcellular localization of FANCD2 is associated with survival in ...

  16. American Society of Hematology
    https://ashpublications.org/blood/article/100/7/...

    S-phase–specific interaction of the Fanconi anemia protein, …

  17. Nature
    https://www.nature.com/articles/s41594-022-00820-9

    The DNA-damage kinase ATR activates the FANCD2-FANCI …

  18. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787816

    FANCD2 and REV1 cooperate in the protection of nascent DNA …

  19. Nature
    https://www.nature.com/articles/s41419-022-04952-0

    FANCD2 maintains replication fork stability during …

  20. PubMed
    https://pubmed.ncbi.nlm.nih.gov/38165804

    The FANCI/FANCD2 complex links DNA damage response to R …

  21. OMIM
    https://www.omim.org/entry/613984

    Entry - *613984 - FANCD2 GENE; FANCD2 | OMIM

  22. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145022

    Monoubiquitinated Fanconi Anemia D2 (FANCD2-Ub) Is …

  23. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576926

    Ferroptosis regulator FANCD2 is associated with immune …

  24. Nature
    https://www.nature.com/articles/s42003-022-04360-2

    FANCD2 promotes mitotic rescue from transcription-mediated …