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- FANCD2 is a central component of the Fanconi anemia pathway for DNA cross-link repair, and its inactivation is associated with progressive bone-marrow failure and cancer predisposition.Author: Johanna Michl, Jutta Zimmer, Francesca M Buffa, Ultan McDermott, Madalena TarsounasPublish Year: 2016
www.nature.com/articles/nsmb.3252 - People also ask
FANCD2 - My Cancer Genome
WEBFANCD2 is an inclusion criterion in 14 clinical trials for ovarian carcinoma, of which 10 are open and 4 are closed. Of the trials that contain FANCD2 status and ovarian …
Pancancer analysis of the prognostic and immunological role of …
WEBMar 5, 2024 · Through this comprehensive pan-cancer analysis, we have gained a deeper understanding of the functions of FANCD2 in oncogenesis and metastasis across …
The Fanconi Anemia/BRCA Pathway: FANCD2 at the …
WEBAt least eleven genes are involved in Fanconi anemia, including the breast cancer susceptibility gene BRCA2. Six of the Fanconi anemia proteins …
- Author: Massimo Bogliolo, Jordi Surrallés
- Published: 2013
- Publish Year: 2013
FANCD2 promotes mitotic rescue from transcription-mediated
WEBDec 21, 2022 · Importantly, co-depleting FANCD2 together with SETX impairs cancer cell proliferation, without significantly affecting non-cancerous cells.
Pan-cancer analysis of the tumorigenic role of Fanconi anemia ...
WEBWe investigated the regulatory effect of FANCD2 on the cell cycle of lung adenocarcinoma cells by flow cytometry, and verified this effect by western blotting. FANCD2 expression …
FANCD2 - Wikipedia
WEBClinical significance. Tobacco smoke suppresses the expression of FANCD2, which codes for a DNA damage "caretaker" or repair mechanism. [20] Cancer.
Overlooked FANCD2 variant encodes a promising, portent tumor …
WEBApr 4, 2017 · Fanconi Anemia (FA) complementation group D2 protein (FANCD2) is the center of the FA tumor suppressor pathway, which has become an important field of …
FANCD2 modulates the mitochondrial stress response to prevent …
WEBJan 29, 2021 · We show that FANCD2, a master regulator of CFS stability, dampens the activation of the mitochondrial stress response and prevents mitochondrial dysfunction.
FANCD2–FANCI is a clamp stabilized on DNA by
WEBFeb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that may recruit other DNA repair factors.
FANCD2 promotes the malignant behavior of endometrial cancer …
WEBDec 15, 2022 · Defective DNA damage repair is a key mechanism affecting tumor susceptibility, treatment response, and survival outcome of endometrial cancer (EC). …
FANCD2 and DNA Damage - PMC - National Center for …
WEBAug 19, 2017 · Fanconi anemia (FA) is a rare human genetic disease displaying various clinical symptoms such as severe bone marrow failure, an extremely high incidence of …
The FANCI/FANCD2 complex links DNA damage response to R …
WEBJan 23, 2024 · Importantly, we found that cancer-associated mutations in SRSF1 are impaired for interaction with FANCD2 and NXF1, leading to decreased FANCD2 …
Expression of FANCD2 is associated with prognosis in patients …
WEBSep 1, 2019 · FANCD2 may be a molecular marker for the early diagnosis and prognosis of NPC. Keywords: Fanconi anemia, head and neck tumor, clinical significance, prognosis, …
FANCD2 limits replication stress and genome instability in
WEBJun 20, 2016 · Here we report that human cancer cells lacking BRCA2 rely on the Fanconi anemia protein FANCD2 to limit replication-fork progression and genomic instability.
FANCD2 | Cancer Genetics Web
WEBFANCD2 is involved in: - BRCA1-dependent Ub-ligase activity BIOCARTA. - Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility BIOCARTA. Data from KEGG and …
The FANCI/FANCD2 complex links DNA damage response to R …
WEBJan 4, 2024 · Fanconi anemia (FA) is characterized by congenital abnormalities, bone marrow failure, and cancer susceptibility. The central FA protein complex …
FBXL12 degrades FANCD2 to regulate replication recovery and …
WEBAug 16, 2023 · In the absence of FBXL12, FANCD2 becomes trapped on chromatin, leading to replication stress and excessive DNA damage. In human cancers, FBXL12, CYCLIN …
FANCD2 inhibits ferroptosis by regulating the JAK2/STAT3 …
WEBFeb 22, 2023 · In this research, we detected the role of FANCD2 on ferroptosis of osteosarcoma cells, FANCD2 knockdown reduced the levels of FTH1 and GPX4, and …
Clinical importance of FANCD2, BRIP1, BRCA1, BRCA2 and …
WEBMar 1, 2019 · Conclusions: Our study shows for the first time that FANCD2 overexpression is a strong negative prognostic factor in ovarian cancer, particularly in patients …
Frontiers | Ferroptosis regulator FANCD2 is associated with …
WEBOct 3, 2022 · In addition, higher FANCD2 expression was related to a higher tumor immune dysfunction and exclusion (TIDE) score, indicating lower responder rates to cancer …
The DNA-damage kinase ATR activates the FANCD2-FANCI …
WEBSep 1, 2022 · Overall, our results demonstrate that phosphorylation primes the FANCD2–FANCI clamp for ubiquitination, showing how multiple posttranslational …
FANCD2 and DNA Damage - PubMed
WEBAug 19, 2017 · Investigators have dedicated considerable effort to understanding the molecular basis underlying Fanconi Anemia (FA), a rare human genetic disease …
FANCD2 FA complementation group D2 [ (human)] - National …
WEBFANCD2 promotes the malignant behavior of endometrial cancer cells and its prognostic value. The AICD fragment of APP initiates a FoxO3a mediated response via …
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