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FANCD2–FANCI is a clamp stabilized on DNA by …
WEBTogether, our structures and biochemical studies explain why and how DNA stimulates FANCD2 monoubiquitination: D2–I binds double-stranded DNA, promoting closure of …
- Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
- DOI: 10.1038/s41594-020-0380-1
- Publish Year: 2020
- Published: 2020/03
FANCD2–FANCI surveys DNA and recognizes double- to single …
WEBJul 31, 2024 · The closed state enables efficient D2–I monoubiquitination to activate Fanconi anaemia DNA repair. As ubiquitin is wedged into the dimerization interface, …
The key to the FANCD2–FANCI lock - Nature
WEBSep 7, 2022 · New cryo-EM structures of the FANCD2–FANCI complex provide insights into how phosphorylation of FANCI facilitates DNA clamping to prime the complex for …
The FA Core Complex Contains a Homo-dimeric Catalytic
WEBJan 17, 2017 · Mono-ubiquitination of FANCI-FANCD2 by the Fanconi anemia core complex activates a major DNA interstrand-crosslink repair pathway important for genome …
- Author: Paolo Swuec, Ludovic Renault, Aaron Borg, Fenil Shah, Vincent J. Murphy, Sylvie van Twest, Ambrosius...
- Publish Year: 2017
Mechanism, specificity, and function of …
WEBJun 17, 2021 · This E2-E3 pair specifically targets the FANCI-FANCD2 heterodimer (ID2 complex) for ubiquitination on DNA. Deubiquitination of both FANCD2 and FANCI, which is also critical for ICL repair, is …
WEBNov 28, 2019 · Together, these experiments explain why and how DNA stimulates FANCD2 monoubiq- uitination: D2-I binds double-stranded DNA, promoting closure of the …
FANCD2–FANCI is a clamp stabilized on DNA by
WEBMar 1, 2020 · We also find that isolated FANCD2 is a dimer, but it adopts a closed conformation that is unable to bind DNA. When incubated with free FANCI, the FANCD2 homodimer exchanges to D2-I, acquiring...
FANCD2-FANCI is a clamp stabilized on DNA by ... - bioRxiv
WEBNov 28, 2019 · When incubated with free FANCI, the FANCD2 homodimer exchanges to D2-I, acquiring DNA binding properties. This suggests an autoinhibitory mechanism that …
Differential functions of FANCI and FANCD2
WEBJun 8, 2020 · Hence, FANCD2 ubiquitination appears to enhance ID2‐DNA binding by reaching the closed state, while FANCI ubiquitination acts to maintain this closed state (and thus the higher DNA affinity), by …
FANCD2 Binds CtIP and Regulates DNA-End …
WEBMay 22, 2014 · A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand crosslinks (ICLs), where it coordinates DNA repair through mechanisms that are still …
The FANCI/FANCD2 complex links DNA damage response to R …
WEBJan 23, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair …
FANCD2 and DNA Damage - PubMed
WEBAug 19, 2017 · Here, we discuss the recent and relevant studies to provide an updated review on the roles of FANCD2 in the DNA damage response. Keywords: DNA damage …
The DNA-damage kinase ATR activates the FANCD2-FANCI …
WEBSep 1, 2022 · Monoubiquitinated FANCD2–FANCI is locked onto DNA and recruits nucleases that mediate DNA repair. However, it remains unclear how phosphorylation …
FANCI and FANCD2 have common as well as independent …
WEBOct 20, 2017 · In this study, we analyzed the functions of FANCD2 and FANCI during DNA replication, using isogenic knockout cell lines. Our results suggest that FANCD2 and …
FANCD2 and DNA Damage - PMC - National Center for …
WEBAug 19, 2017 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, …
FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA
WEBJul 31, 2009 · Eight FA proteins (FANCA, -B, -C, -E, -F, -G, -L and -M) and three non-FA proteins (FAAP100, FAAP24 and HES1) form the FA nuclear core complex that is …
The FA Core Complex Contains a Homo-dimeric Catalytic …
WEBJan 17, 2017 · In the FA/BRCA ICL repair pathway, the FANCI-FANCD2 dimer binds the double helix at the damaged site and acts as a landing platform that recruits a set of …
FANCI forms a monomer and binds DNA whereas FANCD2 is
WEBOur results reveal how monoubiquitinated FANCI:FANCD2 is activated upon DNA binding and present new insights to potentially modulate monoubiquitinated …
FBXL12 degrades FANCD2 to regulate replication recovery and …
WEBAug 16, 2023 · Reconstituting FANCD2-deficient fibroblasts with phosphodegron mutants failed to re-establish fork progression. In the absence of FBXL12, FANCD2 becomes …
Structural insights into 5′ flap DNA unwinding and incision by the ...
WEBDec 11, 2014 · Human FANCD2-associated nuclease 1 (FAN1) is a DNA structure-specific nuclease involved in the processing of DNA interstrand crosslinks (ICLs). FAN1 …
FANCD2-FANCI is a clamp stabilized on DNA by ... - ResearchGate
WEBNov 28, 2019 · We also find that isolated FANCD2 is a dimer, but it adopts a closed conformation that is unable to bind DNA. When incubated with free FANCI, the FANCD2 …
FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ...
WEBDec 26, 2023 · Leung et al. show that FANCD2-dependent mitotic DNA synthesis (MiDAS) in non-transformed human cells relies on PCNA lysine 164 (K164) ubiquitination. …
Agonist antibody to guanylate cyclase receptor NPR1 regulates
WEB22 hours ago · The active peptides bind to and signal through a membrane-bound guanylate cyclase, natriuretic peptide receptor 1/A (NPR1, also known as NPRA). NPR1 …
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