fancd2 dimer dna - Search
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  1. Nature
    https://www.nature.com/articles/s41594-020-0380-1

    FANCD2–FANCI is a clamp stabilized on DNA by

    • A volume of 300 µl of purified D2–I, FANCD2 and FANCI at 1 µM were sequentially run on a Superdex 200 10/300 column (GE Healthcare Life Sciences) equilibrated in 50 mM HEPES, pH 7.5… See more

    Cloning, Expression and Purification

    cDNAs encoding full-length Gallus gallus FANCI and FANCD2 were synthesized (GeneArt) and cloned into pACEBac1. The individual genes were amplified by PCR and cloned … See more

    Nature
    In Vitro Ubiquitination and Purification of Ubiquitinated D2–I

    Based on previously described ubiquitination assays8,28, we set up a large-scale in vitro … See more

    Nature
    Electrophoretic Mobility Shift Assays

    Fluorescently labeled DNA (6FAM-labeled or Alexa647-labeled on the 3ʹ end, purchased from IDT) was prepared by incubating complementary oligonucleotides (Suppleme… See more

    Nature
    Protein Binding Assays

    We used purified StrepII-tagged FANCD2 and His-tagged FANCI to probe their interaction. In a total volume of 50 µl per reaction, FANCD2:FANCI at molar ratios 1:0, 1:0.5, 1… See more

    Nature
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    Cloning, Expression and Purification
    In Vitro Ubiquitination and Purification of Ubiquitinated D2–I
    Electrophoretic Mobility Shift Assays
    Protein Binding Assays
     

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  2. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067600

    FANCD2–FANCI is a clamp stabilized on DNA by …

     

  3. Images of FANCD2 dimer DNA

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  4. Nature
    https://www.nature.com/articles/s41586-024-07770-w

    FANCD2–FANCI surveys DNA and recognizes double- to single …

  5. Nature
    https://www.nature.com/articles/s41594-022-00826-3

    The key to the FANCD2–FANCI lock - Nature

  6. Cell Press
    https://www.cell.com/cell-reports/fulltext/S2211-1247(16)31554-6

    The FA Core Complex Contains a Homo-dimeric Catalytic

  7. FEBS Press
    https://febs.onlinelibrary.wiley.com/doi/full/…

    Mechanism, specificity, and function of …

    WEBJun 17, 2021 · This E2-E3 pair specifically targets the FANCI-FANCD2 heterodimer (ID2 complex) for ubiquitination on DNA. Deubiquitination of both FANCD2 and FANCI, which is also critical for ICL repair, is …

  8. bioRxiv
    https://www.biorxiv.org/content/biorxiv/early/2019/11/28/858225.full.pdf
    [PDF]

    FANCD2-FANCI is a clamp stabilized on DNA by ... - bioRxiv

  9. ResearchGate
    https://www.researchgate.net/publication/…

    FANCD2–FANCI is a clamp stabilized on DNA by

    WEBMar 1, 2020 · We also find that isolated FANCD2 is a dimer, but it adopts a closed conformation that is unable to bind DNA. When incubated with free FANCI, the FANCD2 homodimer exchanges to D2-I, acquiring...

  10. bioRxiv
    https://www.biorxiv.org/content/10.1101/858225v1

    FANCD2-FANCI is a clamp stabilized on DNA by ... - bioRxiv

  11. EMBO Press
    https://www.embopress.org/doi/full/10.152…

    Differential functions of FANCI and FANCD2

    WEBJun 8, 2020 · Hence, FANCD2 ubiquitination appears to enhance ID2‐DNA binding by reaching the closed state, while FANCI ubiquitination acts to maintain this closed state (and thus the higher DNA affinity), by …

  12. Cell Press
    https://www.cell.com/cell-reports/fulltext/S…

    FANCD2 Binds CtIP and Regulates DNA-End …

    WEBMay 22, 2014 · A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand crosslinks (ICLs), where it coordinates DNA repair through mechanisms that are still …

  13. Cell Press
    https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01622-4

    The FANCI/FANCD2 complex links DNA damage response to R …

  14. PubMed
    https://pubmed.ncbi.nlm.nih.gov/28825622

    FANCD2 and DNA Damage - PubMed

  15. Nature
    https://www.nature.com/articles/s41594-022-00820-9

    The DNA-damage kinase ATR activates the FANCD2-FANCI …

  16. Oxford Academic
    https://academic.oup.com/nar/article/45/20/11837/4559113

    FANCI and FANCD2 have common as well as independent …

  17. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578191

    FANCD2 and DNA Damage - PMC - National Center for …

  18. PubMed
    https://pubmed.ncbi.nlm.nih.gov/19379763

    FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA

  19. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S2211124716315546

    The FA Core Complex Contains a Homo-dimeric Catalytic …

  20. ResearchGate
    https://www.researchgate.net/figure/FANCI-forms-a...

    FANCI forms a monomer and binds DNA whereas FANCD2 is

  21. Cell Press
    https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00599-3

    FBXL12 degrades FANCD2 to regulate replication recovery and …

  22. Nature
    https://www.nature.com/articles/ncomms6726

    Structural insights into 5′ flap DNA unwinding and incision by the ...

  23. ResearchGate
    https://www.researchgate.net/publication/337614970...

    FANCD2-FANCI is a clamp stabilized on DNA by ... - ResearchGate

  24. Cell Press
    https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01535-8

    FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ...

  25. Nature
    https://www.nature.com/articles/s41586-024-07903-1

    Agonist antibody to guanylate cyclase receptor NPR1 regulates