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FANCD2–FANCI is a clamp stabilized on DNA by …
WEBAn x-ray crystal structure of the FANCD2–FANCI dimer revealed that the monoubiquitination sites, as well as regulatory FANCI phosphorylation sites, map to the …
- Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
- DOI: 10.1038/s41594-020-0380-1
- Publish Year: 2020
- Published: 2020/03
FANCD2–FANCI surveys DNA and recognizes double- to single …
WEBJul 31, 2024 · The closed state enables efficient D2–I monoubiquitination to activate Fanconi anaemia DNA repair. As ubiquitin is wedged into the dimerization interface, …
- Studies of fancd2 dimerization
The FA Core Complex Contains a Homo-dimeric Catalytic
WEBJan 17, 2017 · A transient interaction with FANCC-FANCE-FANCF alters the FANCI-FANCD2 configuration, stabilizing the dimerization interface. Our data provide a model …
The DNA-damage kinase ATR activates the FANCD2-FANCI …
WEBSep 1, 2022 · Monoubiquitinated FANCD2–FANCI is locked onto DNA and recruits nucleases that mediate DNA repair. However, it remains unclear how phosphorylation …
Mechanism, specificity, and function of …
WEBJun 17, 2021 · Dimonoubiquitination of the FANCI-FANCD2 (ID2) complex is a crucial step in the Fanconi anemia DNA repair pathway. This is achieved by the E2-ubiquitin-conjugating enzyme, UBE2T, and a …
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WEBNov 28, 2019 · To understand the molecular basis of FANCD2 dimerization and gain insight into why it did not bind DNA, we determined the structure of the FANCD2 …
(PDF) Mechanism, specificity, and function of FANCD2-FANCI ...
WEBJun 1, 2021 · FANCD2 ubiquitination stabilizes a secondary FANCD2-FANCI interface formed between the C-terminal 'arms' of each protein (Arm ID2 interface), resulting in …
Differential functions of FANCI and FANCD2
WEBJun 8, 2020 · Our above results demonstrate separate functions for the two monoubiquitination events occurring on the ID2 complex. FANCD2 ubiquitination was found to modulate ID2‐dsDNA binding affinity, …
Structure of the FANCI-FANCD2 Complex: Insights into the …
WEBJul 7, 2011 · The 3.4 Å crystal structure of the ~300 kDa ID complex reveals that monoubiquitination and regulatory phosphorylation sites map to the I-D interface, …
FANCI and FANCD2 have common as well as independent …
WEBOct 20, 2017 · Consistent with this idea, in the Xenopus system the ID2 dimer dissociates upon activation in S-phase, followed by consecutive recruitment of FANCD2 and FANCI …
Structural insight into FANCI–FANCD2 monoubiquitination
WEBJul 29, 2020 · In this review, we summarize these recent advances in the structural and molecular understanding of these key components in the FA pathway, compare the …
The FA Core Complex Contains a Homo-dimeric Catalytic …
WEBJan 17, 2017 · A transient interaction with FANCC-FANCE-FANCF alters the FANCI-FANCD2 configuration, stabilizing the dimerization interface. Our data provide a model …
The key to the FANCD2–FANCI lock - Nature
WEBSep 7, 2022 · New cryo-EM structures of the FANCD2–FANCI complex provide insights into how phosphorylation of FANCI facilitates DNA clamping to prime the complex for …
FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease …
WEBWe characterized three mechanisms of FANCD2-mediated fork protection: (1) The N-terminal domain of FANCD2 inhibits the essential DNA2 nuclease activity by directly …
Mechanism of Ubiquitination and Deubiquitination in the Fanconi …
WEBDec 13, 2016 · As the cycle of FANCD2 monoubiquitination and deubiquitination is critical to the successful repair of DNA interstrand crosslinks, our findings have important mechanistic, biological, and clinical implications for our understanding of ICL repair and the genetic disorder Fanconi anemia.
FANCD2 Binds CtIP and Regulates DNA-End Resection during …
WEBMay 22, 2014 · Our results indicate that FANCD2 directly interacts with CtIP, which associates with chromatin in a manner dependent on FANCD2 and its …
Structural insight into FANCI-FANCD2 monoubiquitination
WEBOct 26, 2020 · In this review, we summarize these recent advances in the structural and molecular understanding of these key components in the FA pathway, compare the …
The FA Core Complex Contains a Homo-dimeric Catalytic …
WEBJan 17, 2017 · A transient interaction with FANCC-FANCE-FANCF alters the FANCI-FANCD2 configuration, stabilizing the dimerization interface. Our data provide a model …
The DNA-damage kinase ATR activates the FANCD2-FANCI …
WEBWhen crosslinks are detected at stalled replication forks, ATR kinase phosphorylates FANCI, which stimulates monoubiquitination of the FANCD2-FANCI clamp by the …
The FANCI/FANCD2 complex links DNA damage response to R …
WEBJan 23, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair …
FANCD2 maintains replication fork stability during ... - Nature
WEBMay 27, 2022 · Despite of the lack of impairment on fork speed in wild type cells, olaparib largely exacerbated 5hmdC-mediated fork defects observed in Fancd2 −/− cells (Fork …
FANCI forms a monomer and binds DNA whereas FANCD2 is
WEBTo understand the molecular basis of FANCD2 dimerization and gain insight into why it did not bind DNA, we determined the structure of the FANCD2 homodimer using cryoEM to …
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