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- Depletion of SETX induces spontaneous under-replication and chromosome fragility due to active transcription and R-loops that persist in mitosis. These fragile loci are targeted by the Fanconi anemia protein, FANCD2, to facilitate the resolution of under-replicated DNA, thus preventing chromosome mis-segregation and allowing cells to proliferate.
www.nature.com/articles/s42003-022-04360-2 FANCD2–FANCI surveys DNA and recognizes double- to single …
Jul 31, 2024 · FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular mechanism that …
FANCD2 - Wikipedia
Fanconi anemia is a disorder with a recessive Mendelian pattern of inheritance characterized by chromosomal instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein co…
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- Studies of fancd2 dna
FANCD2–FANCI is a clamp stabilized on DNA by
Feb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that may recruit other DNA repair factors.
The Fanconi Anemia/BRCA Pathway: FANCD2 at the …
Available data indicate that FANCD2 is involved in cell cycle regulation and DNA repair. Our current knowledge on the functional significance of FA pathway and more specifically FANCD2 and its interacting proteins in pathways of genomic …
FANCD2-FANCI surveys DNA and recognizes double- to single …
DNA crosslinks block DNA replication and are repaired by the Fanconi anaemia pathway. The FANCD2-FANCI (D2-I) protein complex is central to this process as it initiates repair by …
FANCD2 and DNA Damage - PubMed
Aug 19, 2017 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, especially in the …
The DNA-damage kinase ATR activates the FANCD2-FANCI …
Sep 1, 2022 · Monoubiquitinated FANCD2–FANCI is locked onto DNA and recruits nucleases that mediate DNA repair. However, it remains unclear how phosphorylation activates this pathway.
FANCD2–FANCI is a clamp stabilized on DNA by …
Together, our structures and biochemical studies explain why and how DNA stimulates FANCD2 monoubiquitination: D2–I binds double-stranded DNA, promoting closure of the heterodimer to …
The FANCI/FANCD2 complex links DNA damage …
Jan 23, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair and replication fork protection. Defects in the FA pathway lead to …
The FANCI/FANCD2 complex links DNA damage response to R …
Jan 1, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair and …
FANCD2 and DNA Damage - MDPI
Aug 19, 2017 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, especially in the …
DNA repair protein FANCD2 has both ubiquitination-dependent …
Mar 1, 2023 · When DNA interstrand crosslink lesions occur, a core complex of Fanconi anemia proteins promotes the ubiquitination of FANCD2 and FANCI, which recruit downstream factors …
FANCD2-FANCI is a clamp stabilized on DNA by ... - PubMed
Mar 20, 2020 · FANCD2-FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA (dsDNA). Ubiquitin …
FANCD2 Binds CtIP and Regulates DNA-End Resection during …
May 22, 2014 · A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand crosslinks (ICLs), where it coordinates DNA repair through …
The key to the FANCD2–FANCI lock - Nature
Sep 7, 2022 · New cryo-EM structures of the FANCD2–FANCI complex provide insights into how phosphorylation of FANCI facilitates DNA clamping to prime the complex for …
FANCD2 maintains replication fork stability during ... - Nature
May 27, 2022 · A HPLC-MS/MS quantitation of endogenous and exogenous 5hmdC levels in genomic DNA samples of wild type and Fancd2 −/− cells exposed to D3-labeled 5hmdC (0, 10 …
FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand …
Jul 29, 2010 · The mono-ubiquitylated ID complex locates to sites of DNA damage to which it recruits FAN1, a mono-ubiquitin–binding protein. FAN1 has a DNA branch–specific nuclease …
Mechanism, specificity, and function of FANCD2-FANCI
This E2-E3 pair specifically targets the FANCI-FANCD2 heterodimer (ID2 complex) for ubiquitination on DNA. Deubiquitination of both FANCD2 and FANCI, which is also critical for …
Fanconi Anemia: Challenges in Diagnosis and Management—A …
1 day ago · The specific role of FANCD2 is not fully understood, but FANCD2-deficient DT40 cells exhibit deficiencies in homologous recombination-mediated DNA double-strand break repair, …
The Fanconi anemia core complex promotes CtIP-dependent end …
Aug 16, 2024 · Strong enrichment of endogenous FANCD2 was observed in control cells at UV-A laser-induced DNA damage stripes marked by the γH2AX-binding protein MDC1 (Fig. 4c).
FANCD2 promotes mitotic rescue from transcription-
Dec 21, 2022 · Mechanistically, we show that FANCD2 promotes mitotic DNA synthesis that is dependent on XPF and MUS81 endonucleases. Importantly, co-depleting FANCD2 together …
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