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FANCD2–FANCI surveys DNA and recognizes double- to single …
Jul 31, 2024 · FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular mechanism that …
See results only from nature.comThe DNA-damage kinase …
When cross-links are detected at stalled replication forks, ATR kinase …
FANCD2–FANCI is a cla…
Together, our work suggests that FANCD2–FANCI is a clamp that is …
The FANCD2–FANCI compl…
FANCD2 and FANCI are essential components of the Fanconi anaemia …
DNA requirement in FANCD…
Several findings have emerged, namely: (1) occurrence of USP1-UAF1 mediated …
The Fanconi anemia core co…
The FA core complex recognizes crosslinked DNA and subsequently …
The key to the FANCD2–FA…
New cryo-EM structures of the FANCD2–FANCI complex provide …
The DNA-damage kinase ATR activates the FANCD2-FANCI …
Sep 1, 2022 · When cross-links are detected at stalled replication forks, ATR kinase phosphorylates FANCI, which stimulates monoubiquitination of the FANCD2–FANCI clamp by …
FANCD2–FANCI is a clamp stabilized on DNA by
Feb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that may recruit other DNA repair factors.
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FANCD2-FANCI surveys DNA and recognizes double- to single …
DNA crosslinks block DNA replication and are repaired by the Fanconi anaemia pathway. The FANCD2-FANCI (D2-I) protein complex is central to this process as it initiates repair by …
FANCD2-FANCI is a clamp stabilized on DNA by ... - PubMed
Mar 20, 2020 · FANCD2-FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA (dsDNA). Ubiquitin …
Mechanism, specificity, and function of FANCD2-FANCI
At the center of the pathway is the monoubiquitination of two FA proteins, FANCD2 and FANCI, on two specific lysine residues. This is achieved by the combined action of the UBE2T …
The FANCI/FANCD2 complex links DNA damage …
Jan 23, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair and replication fork protection. Defects in the FA pathway lead to …
FANCD2–FANCI is a clamp stabilized on DNA by …
FANCD2–FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA. Ubiquitin is positioned at the interface …
FANCD2 Gene - GeneCards | FACD2 Protein
Oct 2, 2024 · FANCD2 (FA Complementation Group D2) is a Protein Coding gene. Diseases associated with FANCD2 include Fanconi Anemia, Complementation Group D2 and Fanconi Anemia, Complementation Group A. …
Structure of the FANCI-FANCD2 Complex: Insights …
Jul 15, 2011 · Fanconi anemia is a cancer predisposition syndrome caused by defects in the repair of DNA interstrand cross-links (ICLs). Central to this pathway is the Fanconi anemia I–Fanconi anemia D2 (FANCI-FANCD2) (ID) complex, …
DNA repair protein FANCD2 has both ubiquitination-dependent …
Mar 1, 2023 · When DNA interstrand crosslink lesions occur, a core complex of Fanconi anemia proteins promotes the ubiquitination of FANCD2 and FANCI, which recruit downstream factors …
The FANCD2–FANCI complex is recruited to DNA interstrand
Jul 13, 2016 · FANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2 …
Differential functions of FANCI and FANCD2 ... - EMBO reports
Jun 8, 2020 · A FA patient mutation in FANCI, R1285Q, which reduces ubiquitination of the ID2 complex 20, has been suggested to reduce both FANCI and ID2 DNA binding, as well as …
FANCD2 facilitates replication through common fragile sites
Oct 10, 2016 · Bidirectional replication fork movement observed in FANCD2 monoub−/− and FANCI monoub−/− lymphoblasts indicates that the monoubiquitination of FANCD2 is perhaps …
Monoubiquitinated Fanconi Anemia D2 (FANCD2-Ub) Is …
Fanconi D2 (FANCD2) is monoubiquitinated on K561 (FANCD2-Ub) in response to DNA double-strand breaks (DSBs) to stimulate repair of these potentially lethal DNA lesions.
Regulated interaction of the Fanconi anemia protein, FANCD2, …
Feb 1, 2005 · A critical regulatory event in the FA/BRCA pathway is the monoubiquitination of FANCD2 on Lysine 561. 10 Analysis of FANCD2 monoubiquitination provides a rapid …
DNA requirement in FANCD2 deubiquitination by USP1-UAF1
Jun 28, 2019 · Several findings have emerged, namely: (1) occurrence of USP1-UAF1 mediated-deubiquitination of FANCD2 on DNA; (2) identification of UAF1 amino acid residues important …
FANCD2 protects genome stability by recruiting RNA …
Nov 15, 2018 · FANCD2 has been suggested to orchestrate various activities during ICL repair, including protection and restart of the stalled replication forks. FANCD2 promotes HR, perhaps by stabilizing RAD51 filaments or promoting …
The key to the FANCD2–FANCI lock - Nature
Sep 7, 2022 · New cryo-EM structures of the FANCD2–FANCI complex provide insights into how phosphorylation of FANCI facilitates DNA clamping to prime the complex for …
Fanconi anemia - Wikipedia
Fanconi anemia (FA) is a rare, autosomal recessive, genetic disease resulting in impaired response to DNA damage in the FA/BRCA pathway. Although it is a very rare disorder, study …
The Fanconi anemia core complex promotes CtIP-dependent end …
Aug 16, 2024 · The FA core complex recognizes crosslinked DNA and subsequently ubiquitinates the FANCD2/FANCI heterodimer 18. This is an essential step to recruit nucleases that remove …
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