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FANCD2–FANCI surveys DNA and recognizes double- to single …
See results only from nature.comFANCD2–FANCI is a cla…
Together, our work suggests that FANCD2–FANCI is a clamp that is …
The DNA-damage kinase …
When cross-links are detected at stalled replication forks, ATR kinase …
The key to the FANCD2–FA…
New cryo-EM structures of the FANCD2–FANCI complex provide …
DNA requirement in FANCD…
Here, the authors have developed a set of biochemical tools to reconstitute …
The FANCD2–FANCI compl…
FANCD2 and FANCI are essential components of the Fanconi anaemia …
FANCD2–FANCI is a clamp stabilized on DNA by
WEBFeb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that may recruit other DNA repair factors.
The DNA-damage kinase ATR activates the FANCD2-FANCI …
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FANCD2-FANCI is a clamp stabilized on DNA by ... - PubMed
Mechanism, specificity, and function of FANCD2-FANCI
The FANCI/FANCD2 complex links DNA damage …
WEBJan 23, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair and replication fork protection. Defects …
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Differential functions of FANCI and FANCD2
WEBJun 8, 2020 · A FA patient mutation in FANCI, R1285Q, which reduces ubiquitination of the ID2 complex 20, has been suggested to reduce both FANCI and ID2 DNA binding, as well as FANCI interaction with …
DNA repair protein FANCD2 has both ubiquitination-dependent …
FANCD2-FANCI surveys DNA and recognizes double- to single …
FBXL12 degrades FANCD2 to regulate replication …
WEBAug 16, 2023 · Fanconi anemia (FA) signaling, a key genomic maintenance pathway, is activated in response to replication stress. Here, we report that phosphorylation of the pivotal pathway protein FANCD2 by CHK1 …
Structure of the FANCI-FANCD2 Complex: Insights …
WEBJul 15, 2011 · Fanconi anemia is a cancer predisposition syndrome caused by defects in the repair of DNA interstrand cross-links (ICLs). Central to this pathway is the Fanconi anemia I–Fanconi anemia D2 (FANCI-FANCD2) …
The key to the FANCD2–FANCI lock - Nature
Structural and biochemical basis of interdependent FANCI …
Structure of the FANCI-FANCD2 Complex: Insights into the …
The FANCD2–FANCI complex is recruited to DNA interstrand
FANCD2-FANCI is a sliding DNA clamp that specifically …
FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand …
FANCD2–FANCI surveys DNA and recognizes double- to single …
DNA requirement in FANCD2 deubiquitination by USP1-UAF1
The Fanconi anemia pathway induces chromothripsis and ecDNA …
FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody