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Bokep
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Nature
https://www.nature.com/articles/s41586-024-07770-w
FANCD2–FANCI surveys DNA and recognizes double- to single …
WEBJul 31, 2024 · FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular …
- FANCD2–FANCI is a cla…
  Together, our work suggests that FANCD2–FANCI is a clamp that is …
- The DNA-damage kinase …
  When cross-links are detected at stalled replication forks, ATR kinase …
- The key to the FANCD2–FA…
  New cryo-EM structures of the FANCD2–FANCI complex provide …
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FANCD2 Chromatin
FANCD2 Fanci Structure
FANCD2 Tower
FANCD2 and P53
researchgate.net
Domain architecture and structure of FANCD2 and FANCI. (A) Schematic of ...
researchgate.net
Dynamic FA pathway model. The FANCD2–FANCI dimer represents the ...
zhuanlan.zhihu.com
FANCI和FANCD2不同的泛素化功能使ID2-DNA稳定结合 - 知乎
mdpi.com
IJMS | Free Full-Text | FANCD2 and DNA Damage
researchgate.net
Model for regulation of FANCD2 and FANCI in DNA crosslink repair ...
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Nature
https://www.nature.com/articles/s41594-0…
FANCD2–FANCI is a clamp stabilized on DNA by
WEBFeb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that …
Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
Publish Year: 2020
Nature
https://www.nature.com/articles/s41594-022-00820-9
The DNA-damage kinase ATR activates the FANCD2-FANCI …
WEBSep 1, 2022 · When cross-links are detected at stalled replication forks, ATR kinase phosphorylates FANCI, which stimulates monoubiquitination of the FANCD2–FANCI …
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PubMed
FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair
Vertebrate DNA crosslink repair excises toxic replication-blocking DNA crosslinks. Numerous factors involved in crosslink repair have been identified, and mutations in their corresponding genes cause Fanconi anemia (FA). A key step in crosslink repair
Author: Pablo Alcón
Published: 2020/3
Keywords: National In…
PubMed
Mechanism, specificity, and function of FANCD2-FANCI ubiquitination and deubiquitination
Fanconi anemia (FA) is a rare genetic disorder caused by mutations in any of the currently 22 known FA genes. The products of these genes, along with other FA-associated proteins, participate in a biochemical pathway, known as the FA pathway. This pathway
Author: Kimon Lemonidis
Published: 2022/8
Keywords: DNA repair…
National Center for Biotechnology Information
FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair
Vertebrate DNA crosslink repair excises toxic replication-blocking DNA crosslinks. Numerous factors involved in crosslink repair have been identified, and mutations in their corresponding genes cause Fanconi anemia (FA). A key step in crosslink repair
Author: Pablo Alcón, S…
Published: 2020/03
DOI: 10.1038/s41594-0…
febs.onlinelibrary.wiley.com
Mechanism, specificity, and function of FANCD2-FANCI ubiquitination and deubiquitination
Fanconi anemia (FA) is a rare genetic disorder caused by mutations in any of the currently 22 known FA genes. The products of these genes, along with other FA-associated proteins, participate in a biochemical pathway, known as the FA pathway. This pathway
Author: Kimon Lemoni…
Published: 17 June 2021
Cited By: 12
National Center for Biotechnology Information
Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway
Fanconi Anemia is a cancer predisposition syndrome caused by defects in the repair of DNA interstrand crosslinks (ICL). Central to this pathway is the FANCI-FANCD2 (ID) complex, which is activated by DNA damage-induced phosphorylation and monoubiquitination.
Author: Woo Joo, Guo…
Published: 2011/07/07
DOI: 10.1126/science.1…
National Center for Biotechnology Information
Functional and physical interaction between the mismatch repair and FA-BRCA pathways
Fanconi anemia (FA) is a rare genetic disorder characterized by bone marrow failure and an increased risk for leukemia and cancer. Fifteen proteins thought to function in the repair of DNA interstrand crosslinks (ICLs) comprise what is known as the FA-BRCA
Author: Stacy A. Willia…
Published: 2011/11/11
Publication: Hum Mol …
PubMed
The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export
Fanconi anemia (FA) is characterized by congenital abnormalities, bone marrow failure, and cancer susceptibility. The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink
Author: Anne Olazaba…
Published: 2024 Jan
Keywords: CP: Molecu…
National Center for Biotechnology Information
FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress
REV1 is a eukaryotic member of the Y-family of DNA polymerases involved in translesion DNA synthesis and genome mutagenesis. Recently, REV1 is also found to function in homologous recombination. However, it remains unclear how REV1 is recruited to the
Author: Yeran Yang, Z…
Published: 2015/09/09
Publication: Nucleic A…
National Center for Biotechnology Information
FANCD2 facilitates replication through common fragile sites
Nearly two-thirds of the human genome is comprised of repetitive sequences that often challenge DNA replication, which can lead to genomic instability. CFSs are chromosomal regions that are most prone to genomic instability and are implicated in the development
Author: Advaitha Madir…
Published: 2016/10/10
DOI: 10.1016/j.molcel.2…
National Center for Biotechnology Information
Ouabain, a Cardiac Glycoside, Inhibits the Fanconi Anemia/BRCA Pathway Activated by DNA Interstrand Cross-Linking Agents
Modulation of the DNA repair pathway is an emerging target for the development of anticancer drugs. DNA interstrand cross-links (ICLs), one of the most severe forms of DNA damage caused by anticancer drugs such as cisplatin and mitomycin C (MMC), activates
Author: Dong Wha Jun…
Published: 2013
Publication: PLoS On…
PubMed
https://pubmed.ncbi.nlm.nih.gov/32066963
FANCD2-FANCI is a clamp stabilized on DNA by ... - PubMed
WEBMar 20, 2020 · FANCD2-FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA (dsDNA). …
- Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
- Publish Year: 2020
PubMed
https://pubmed.ncbi.nlm.nih.gov/34137174
Mechanism, specificity, and function of FANCD2-FANCI
WEBAt the center of the pathway is the monoubiquitination of two FA proteins, FANCD2 and FANCI, on two specific lysine residues. This is achieved by the combined action of the …
- Author: Kimon Lemonidis, Connor Arkinson, Martin L. Rennie, Helen Walden
- Publish Year: 2021
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067600
FANCD2–FANCI is a clamp stabilized on DNA by …
WEBFANCD2–FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA. Ubiquitin …
PubMed
https://pubmed.ncbi.nlm.nih.gov/39085614
FANCD2-FANCI surveys DNA and recognizes double- to single …
WEBDNA crosslinks block DNA replication and are repaired by the Fanconi anaemia pathway. The FANCD2-FANCI (D2-I) protein complex is central to this process as it initiates repair …
FEBS Press
https://febs.onlinelibrary.wiley.com/doi/full/…
Mechanism, specificity, and function of …
WEBJun 17, 2021 · A key step in the FA pathway is the monoubiquitination of FA proteins FANCD2 and FANCI. This is a crucial event because it results in the formation of FANCI-FANCD2 nuclear foci where numerous …
EMBO Press
https://www.embopress.org/doi/full/10.152…
Differential functions of FANCI and FANCD2
WEBJun 8, 2020 · A FA patient mutation in FANCI, R1285Q, which reduces ubiquitination of the ID2 complex 20, has been suggested to reduce both FANCI and ID2 DNA binding, as well as FANCI interaction with …
Cell Press
https://www.cell.com/cell-reports/fulltext/S…
The FANCI/FANCD2 complex links DNA damage …
WEBJan 23, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair and replication fork protection. Defects …
bioRxiv
https://www.biorxiv.org/content/10.1101/858225v1
FANCD2-FANCI is a clamp stabilized on DNA by ... - bioRxiv
WEBNov 28, 2019 · When incubated with free FANCI, the FANCD2 homodimer exchanges to D2-I, acquiring DNA binding properties. This suggests an autoinhibitory mechanism that …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310437
Structure of the FANCI-FANCD2 Complex: Insights into the …
WEBJul 7, 2011 · Fanconi Anemia is a cancer predisposition syndrome caused by defects in the repair of DNA interstrand crosslinks (ICL). Central to this pathway is the FANCI-FANCD2 …
Cell Press
https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00599-3
FBXL12 degrades FANCD2 to regulate replication recovery and …
WEBAug 16, 2023 · Fanconi anemia (FA) signaling, a key genomic maintenance pathway, is activated in response to replication stress. Here, we report that phosphorylation of the …
Cell Press
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00732-5
Phosphorylation by ATR triggers FANCD2 chromatin loading and …
WEBJul 25, 2023 · Once ATR phosphorylates FANCD2, the DNA affinity of the FANCD2/FANCI complex increases, licensing it for loading onto ICLs residing on …
Nature
https://www.nature.com/articles/s41594-022-00826-3
The key to the FANCD2–FANCI lock - Nature
WEBSep 7, 2022 · New cryo-EM structures of the FANCD2–FANCI complex provide insights into how phosphorylation of FANCI facilitates DNA clamping to prime the complex for …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196888
Functional and physical interaction between the mismatch repair …
WEBNov 11, 2011 · FANCD2 monoubiquitylation, foci formation and chromatin loading are greatly diminished in MSH2-deficient cells. Human or mouse cells lacking MSH2 or …
Oxford Academic
https://academic.oup.com/nar/article/45/20/11837/4559113
FANCI and FANCD2 have common as well as independent …
WEBOct 20, 2017 · FANCD2 and FANCI are partially independent for their protein stability, nuclear import and chromatin recruitment and contribute separately to normal cell …
Cell Press
https://www.cell.com/cell-reports/pdf/S2211-1247(23)01622-4.pdf
[PDF]
The FANCI/FANCD2 complex links DNA damage response …
WEBThe central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair and replication fork …
PubMed
https://pubmed.ncbi.nlm.nih.gov/38165804
The FANCI/FANCD2 complex links DNA damage response to R …
WEBJan 4, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787816
FANCD2 and REV1 cooperate in the protection of nascent DNA …
WEBSep 9, 2015 · Expression of a FANCD2-Ub chimeric protein in RAD18-depleted cells enhances REV1 assembly at laser-damaged sites, suggesting that FANCD2-mUb …
GeneCards
https://www.genecards.org/cgi-bin/carddisp.pl?gene=FANCD2
FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody
WEBAug 6, 2024 · FANCD2 (FA Complementation Group D2) is a Protein Coding gene. Diseases associated with FANCD2 include Fanconi Anemia, Complementation Group …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683400
FANCD2 facilitates replication through common fragile sites
WEBOct 10, 2016 · Complementation of FANCD2 −/− fibroblasts with wild-type protein ( Fig. S6B) led to an increase in replication initiation events (9 in 40 examined) at CFS …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790830
Ouabain, a Cardiac Glycoside, Inhibits the Fanconi …
WEBOct 4, 2013 · We observed that ouabain, as well as other cardiac glycoside family members―digitoxin and digoxin―down-regulated FANCD2 and FANCI mRNA levels, …
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