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FANCD2–FANCI surveys DNA and recognizes double- to single …
WEBJul 31, 2024 · FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular …
FANCD2–FANCI is a clamp stabilized on DNA by
WEBFeb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that …
- Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
- Publish Year: 2020
FANCD2-FANCI is a clamp stabilized on DNA by ... - PubMed
WEBMar 20, 2020 · FANCD2-FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA (dsDNA). …
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The DNA-damage kinase ATR activates the FANCD2-FANCI …
WEBSep 1, 2022 · When cross-links are detected at stalled replication forks, ATR kinase phosphorylates FANCI, which stimulates monoubiquitination of the FANCD2–FANCI …
Mechanism, specificity, and function of FANCD2-FANCI
WEBAt the center of the pathway is the monoubiquitination of two FA proteins, FANCD2 and FANCI, on two specific lysine residues. This is achieved by the combined action of the …
FANCD2–FANCI is a clamp stabilized on DNA by …
WEBFANCD2–FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA. Ubiquitin …
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The FANCI/FANCD2 complex links DNA damage …
WEBJan 23, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair and replication fork protection. Defects …
Differential functions of FANCI and FANCD2
WEBJun 8, 2020 · A FA patient mutation in FANCI, R1285Q, which reduces ubiquitination of the ID2 complex 20, has been suggested to reduce both FANCI and ID2 DNA binding, as well as FANCI interaction with …
DNA repair protein FANCD2 has both ubiquitination-dependent …
WEBMar 1, 2023 · When DNA interstrand crosslink lesions occur, a core complex of Fanconi anemia proteins promotes the ubiquitination of FANCD2 and FANCI, which recruit …
FBXL12 degrades FANCD2 to regulate replication …
WEBAug 16, 2023 · Fanconi anemia (FA) signaling, a key genomic maintenance pathway, is activated in response to replication stress. Here, we report that phosphorylation of the pivotal pathway protein FANCD2 by CHK1 …
Mechanism, specificity, and function of …
WEBJun 17, 2021 · Dimonoubiquitination of the FANCI-FANCD2 (ID2) complex is a crucial step in the Fanconi anemia DNA repair pathway. This is achieved by the E2-ubiquitin-conjugating enzyme, UBE2T, and a …
FANCD2-FANCI surveys DNA and recognizes double- to single …
WEBDNA crosslinks block DNA replication and are repaired by the Fanconi anaemia pathway. The FANCD2-FANCI (D2-I) protein complex is central to this process as it initiates repair …
The key to the FANCD2–FANCI lock - Nature
WEBSep 7, 2022 · New cryo-EM structures of the FANCD2–FANCI complex provide insights into how phosphorylation of FANCI facilitates DNA clamping to prime the complex for …
Structure of the FANCI-FANCD2 Complex: Insights into the
WEBJul 15, 2011 · Fanconi anemia is a cancer predisposition syndrome caused by defects in the repair of DNA interstrand cross-links (ICLs). Central to this pathway is the Fanconi …
WEBReconstituting FANCD2-deficient fibroblasts with phosphodegron mutants failed to re-establish fork pro-gression. In the absence of FBXL12, FANCD2 becomes trapped on …
Structure of the FANCI-FANCD2 Complex: Insights into the …
WEBJul 7, 2011 · Fanconi Anemia is a cancer predisposition syndrome caused by defects in the repair of DNA interstrand crosslinks (ICL). Central to this pathway is the FANCI-FANCD2 …
The FANCD2–FANCI complex is recruited to DNA interstrand
WEBJul 13, 2016 · FANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2 …
The Fanconi anemia pathway induces chromothripsis and ecDNA …
WEBAug 23, 2024 · Inactivation of the FA pathway suppresses chromosome shattering during mitosis without impacting interphase-associated defects within micronuclei. Mono …
FANCD2–FANCI surveys DNA and recognizes double- to single …
WEBJul 31, 2024 · FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular …
FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody
WEBAug 6, 2024 · FANCD2 (FA Complementation Group D2) is a Protein Coding gene. Diseases associated with FANCD2 include Fanconi Anemia, Complementation Group …
DNA clamp function of the monoubiquitinated Fanconi anaemia …
WEBMar 11, 2020 · Cryo-EM structures of the FANCI–FANCD2 complex bound to DNA reveal that monoubiquitination triggers structural changes that enable the complex to function …
FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand …
WEBThe mono-ubiquitylated ID complex locates to sites of DNA damage to which it recruits FAN1, a mono-ubiquitin–binding protein. FAN1 has a DNA branch–specific nuclease …
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