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WEBJul 30, 2024 · FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified …
FANCD2–FANCI is a cla…
Together, our work suggests that FANCD2–FANCI is a clamp that is …
The DNA-damage kinase …
When cross-links are detected at stalled replication forks, ATR kinase …
The key to the FANCD2–FA…
New cryo-EM structures of the FANCD2–FANCI complex provide …
The FANCD2–FANCI compl…
FANCD2 and FANCI are essential components of the Fanconi anaemia …
See results only from nature.comWEBFeb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that …
- Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
- Publish Year: 2020
WEBSep 1, 2022 · When cross-links are detected at stalled replication forks, ATR kinase phosphorylates FANCI, which stimulates monoubiquitination of the FANCD2–FANCI …
- Studies of fancd2 fanci
WEBMar 20, 2020 · FANCD2-FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA (dsDNA). …
WEBAt the center of the pathway is the monoubiquitination of two FA proteins, FANCD2 and FANCI, on two specific lysine residues. This is achieved by the combined action of the …
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WEBFANCD2–FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA. Ubiquitin …
WEBJun 17, 2021 · A key step in the FA pathway is the monoubiquitination of FA proteins FANCD2 and FANCI. This is a crucial event because it results in the formation of FANCI-FANCD2 nuclear foci where numerous …
WEBJul 29, 2020 · In this review, we summarize these recent advances in the structural and molecular understanding of these key components in the FA pathway, compare the …
WEBNov 28, 2019 · When incubated with free FANCI, the FANCD2 homodimer exchanges to D2-I, acquiring DNA binding properties. This suggests an autoinhibitory mechanism that …
WEBJun 8, 2020 · A FA patient mutation in FANCI, R1285Q, which reduces ubiquitination of the ID2 complex 20, has been suggested to reduce both FANCI and ID2 DNA binding, as well as FANCI interaction with …
FANCI and FANCD2 have common as well as independent …
WEBNov 16, 2017 · We show that FANCI and FANCD2 are partially independent regarding their protein stability, nuclear localization and chromatin recruitment and contribute …
The FANCI/FANCD2 complex links DNA damage response to R …
WEBJan 1, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair …
Decades-Old Mystery Solved: Scientists Crack the Code of
WEB3 days ago · By Medical Research Council (MRC) Laboratory of Medical Sciences August 3, 2024. Researchers from the UK’s Medical Research Council Research Institutes have …
The key to the FANCD2–FANCI lock - Nature
WEBSep 7, 2022 · New cryo-EM structures of the FANCD2–FANCI complex provide insights into how phosphorylation of FANCI facilitates DNA clamping to prime the complex for …
WEBThe central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair and replication fork …
Structure of the FANCI-FANCD2 Complex: Insights into the …
WEBJul 7, 2011 · Fanconi Anemia is a cancer predisposition syndrome caused by defects in the repair of DNA interstrand crosslinks (ICL). Central to this pathway is the FANCI-FANCD2 …
FANCD2 - Wikipedia
WEBFanconi anemia is a disorder with a recessive Mendelian pattern of inheritance characterized by chromosomal instability, hypersensitivity to DNA crosslinking agents, …
FANCD2, FANCJ and BRCA2 cooperate to promote replication …
WEBOur results support a non-linear FA pathway model at stalled replication forks, where the nonubiquitinated FANCD2 isoform - in concert with FANCJ and BRCA2 - fulfills a …
The Fanconi Anemia DNA Repair Pathway - Fanconi Cancer …
WEBFanconi anemia (FA) is caused by faulty DNA repair of interstrand crosslinks (ICLs) in every cell in patients with the disease. Researchers have discovered 23 genes to date that …
FANCI and FANCD2 have common as well as independent …
WEBOct 20, 2017 · FANCD2 and FANCI are partially independent for their protein stability, nuclear import and chromatin recruitment and contribute separately to normal cell …
The FANCD2–FANCI complex is recruited to DNA interstrand
WEBJul 13, 2016 · FANCD2 and FANCI are essential components of the Fanconi anaemia DNA damage repair pathway. Here the authors present the cryo-EM structure of the FANCD2 …
Clinical Validation of the Somatic FANCD2 Mutation (c.2022 …
WEBThe FANCI-FANCD2 heterodimer is present where the FA pathway comes together . It serves as a substrate for the FA core complex as well as a potential collecting site for …
FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody
WEBApr 3, 2024 · FANCD2 (FA Complementation Group D2) is a Protein Coding gene. Diseases associated with FANCD2 include Fanconi Anemia, Complementation Group …
DNA repair discovery sparks cancer hope - 2024 - Wiley …
WEB1 day ago · Alcón, P., et al.: FANCD2–FANCI surveys DNA and recognizes double- to single-stranded junctions. Nature (2024); DOI: 10.1038/s41586-024-07770-w. About the …
FANCD2 FA complementation group D2 [ (human)] - National …
WEBThis gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci …
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