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  2. Mono-ubiquination of FANCD2 is essential for repairing DNA interstrand crosslinks, and clamps the protein on DNA together with its partner protein FANCI. The monoubiquitinated FANCD2:FANCI complex coats DNA in a filament-like array, potentially as a way to protect DNA associated with stalled replication.

    FANCD2 - Wikipedia

    en.wikipedia.org/wiki/FANCD2
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  3. People also ask
    What is FANCI & FANCD2?FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response Fanconi anemia (FA) is an inherited cancer predisposition syndrome characterized by cellular hypersensitivity to DNA interstrand crosslinks (ICLs).

    FANCI and FANCD2 have common as well as independent

    pubmed.ncbi.nlm.nih.gov
    Do FANCD2 and FANCI function in DNA replication?In this study, we analyzed the functions of FANCD2 and FANCI during DNA replication, using isogenic knockout cell lines. Our results suggest that FANCD2 and FANCI fulfill partially independent and at times opposing roles in the cellular replication stress response (Figure 9 ).

    FANCI and FANCD2 have common as well as independent functions du…

    academic.oup.com
    Do FANCI and FANCD2 have a common function?FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response Nucleic Acids Res. 2017 Nov 16;45(20):11837-11857.doi: 10.1093/nar/gkx847. Authors

    FANCI and FANCD2 have common as well as independent

    pubmed.ncbi.nlm.nih.gov
    Are FANCI and FANCD2 independent?We show that FANCI and FANCD2 are partially independent regarding their protein stability, nuclear localization and chromatin recruitment and contribute independently to cellular proliferation. Simultaneously, FANCD2—but not FANCI—plays a major role in HDR-mediated replication restart and in suppressing new origin firing.

    FANCI and FANCD2 have common as well as independent functions du…

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  4. PubMed
    https://pubmed.ncbi.nlm.nih.gov/34137174

    Mechanism, specificity, and function of FANCD2-FANCI

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  5. Nature
    https://www.nature.com/articles/s41594-0…

    FANCD2–FANCI is a clamp stabilized on DNA by

    WEBFeb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that …

    • Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
    • Publish Year: 2020

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    FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand …
    science.org
    FANCD2 modulates the mitochondrial stress response to …
    nature.com
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  6. Studies of fancd2 fanci function
    PubMed
    FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response
    Fanconi anemia (FA) is an inherited cancer predisposition syndrome characterized by cellular hypersensitivity to DNA interstrand crosslinks (ICLs). To repair these lesions, the FA proteins act in a linear hierarchy: following ICL detection on chromatin,
    Author: Elizabeth L Th…
    Published: 2017/11/16
    Keywords: National In…
    febs.onlinelibrary.wiley.com
    Mechanism, specificity, and function of FANCD2-FANCI ubiquitination and deubiquitination
    Fanconi anemia (FA) is a rare genetic disorder caused by mutations in any of the currently 22 known FA genes. The products of these genes, along with other FA-associated proteins, participate in a biochemical pathway, known as the FA pathway. This pathway
    Author: Kimon Lemoni…
    Published: 17 June 2021
    Cited By: 12
    National Center for Biotechnology Information
    FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair
    Vertebrate DNA crosslink repair excises toxic replication-blocking DNA crosslinks. Numerous factors involved in crosslink repair have been identified, and mutations in their corresponding genes cause Fanconi anemia (FA). A key step in crosslink repair
    Author: Pablo Alcón, S…
    Published: 2020/03
    DOI: 10.1038/s41594-0…
    National Center for Biotechnology Information
    Structural insight into FANCI–FANCD2 monoubiquitination
    The Fanconi anemia (FA) pathway coordinates a faithful repair mechanism for DNA damage that blocks DNA replication, such as interstrand cross-links. A key step in the FA pathway is the conjugation of ubiquitin on to FANCD2 and FANCI, which is facilitated
    Author: Landing Li, Wi…
    Published: 2020/10
    Publication: Essays Bi…
    ResearchGate
    Mechanism, specificity, and function of FANCD2-FANCI ubiquitination and deubiquitination
    Fanconi anemia (FA) is a rare genetic disorder caused by mutations in any of the currently 22 known FA genes. The products of these genes, along with other FA‐associated proteins, participate in a biochemical pathway, known as the FA pathway. This pathway
    Author: Kimon Lemoni…
    Published: 2021/06/01
    DOI: 10.1111/febs.16077
    National Center for Biotechnology Information
    FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response
    Fanconi anemia (FA) is an inherited cancer predisposition syndrome characterized by cellular hypersensitivity to DNA interstrand crosslinks (ICLs). To repair these lesions, the FA proteins act in a linear hierarchy: following ICL detection on chromatin,
    Author: Elizabeth L. Th…
    Published: 2017/11/11
    Publication: Nucleic A…
    PubMed
    FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex
    Fanconi Anemia (FA) is an inherited multi-gene cancer predisposition syndrome that is characterized on the cellular level by a hypersensitivity to DNA interstrand crosslinks (ICLs). To repair these lesions, the FA pathway proteins are thought to act in
    Author: Maya Raghun…
    Published: 2015
    Keywords: FA pathwa…
  7. Nature
    https://www.nature.com/articles/nrm.2016.48

    The Fanconi anaemia pathway: new players and new functions

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    Fanconi anemia pathway: Current Biology - Cell Press
    cell.com
    Fanconi anemia pathway - PubMed
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  8. Nature
    https://www.nature.com/articles/s41586-024-07770-w

    FANCD2–FANCI surveys DNA and recognizes double- to single …

  9. Oxford Academic
    https://academic.oup.com/nar/article/45/20/11837/4559113

    FANCI and FANCD2 have common as well as independent …

    Tags:
    Fancd2 and Fanci
    Fancd2 Antibody
    Fancd2 Gene in Ovarian Cancer
  10. PubMed
    https://pubmed.ncbi.nlm.nih.gov/29059323

    FANCI and FANCD2 have common as well as independent …

    Tags:
    Fancd2 and Fanci
    Publish Year:2017
  11. FEBS Press
    https://febs.onlinelibrary.wiley.com/doi/full/…

    Mechanism, specificity, and function of …

    WEBJun 17, 2021 · Fanconi anemia (FA) is a rare genetic disorder caused by mutations in any of the currently 22 known FA genes. The products of these genes, along with other FA-associated proteins, participate in a …

    Tags:
    Fanconi Anemia
    Publish Year:2021
    Cited By:12
    17 June 2021
  12. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067600

    FANCD2–FANCI is a clamp stabilized on DNA by …

    Tags:
    Fancd2 and Fanci
    Publish Year:2020
    Fanci D2
    Published:2020/03
  13. Cell Press
    https://www.cell.com/biophysj/fulltext/S0006-3495(23)01812-X

    FANCD2-FANCI is a sliding DNA clamp that specifically …

  14. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588663

    Structural insight into FANCI–FANCD2 monoubiquitination - PMC

    Tags:
    Fancd2 and Fanci
    Publish Year:2020
    Published:2020/10
  15. Oxford Academic
    https://academic.oup.com/nar/article/47/14/7532/5521033

    Fanci knockout mouse model reveals common and distinct …

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    Fancd2 and Fanci
    Fancc Knockout Mouse From Jackson Lab
    Fanci Gene Mutation
  16. ResearchGate
    https://www.researchgate.net/publication/352481421...

    (PDF) Mechanism, specificity, and function of FANCD2-FANCI ...

  17. Wikipedia
    https://en.wikipedia.org/wiki/FANCD2

    FANCD2 - Wikipedia

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    Fanconi Anemia
    FANCD2
  18. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714191

    FANCI and FANCD2 have common as well as independent …

    Tags:
    Fancd2 and Fanci
    Publish Year:2017
    10.1093/nar/gkx847
    Published:2017/11/11
  19. Nature
    https://www.nature.com/articles/s41594-022-00826-3

    The key to the FANCD2–FANCI lock - Nature

    Tags:
    DNA
    FANCI
  20. Cell Press
    https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01622-4

    The FANCI/FANCD2 complex links DNA damage response to R …

  21. EMBO Press
    https://www.embopress.org/doi/full/10.15252/embr.202050133

    Differential functions of FANCI and FANCD2 ubiquitination …

    Tags:
    Fancd2 and Fanci
    Fancd2 Antibody
    Publish Year:2020
    Fancd2 Gene
  22. Cell Press
    https://www.cell.com/molecular-cell/fulltext/S1097-2765(13)00549-2

    FANCD2 Binds MCM Proteins and Controls Replisome Function …

    Tags:
    Fanconi Anemia
    Publish Year:2013
  23. Nature
    https://www.nature.com/articles/s41417-024-00797-1

    Deciphering the role of post-translational modifications in ... - Nature

  24. PubMed
    https://pubmed.ncbi.nlm.nih.gov/25659033

    FANCD2, FANCJ and BRCA2 cooperate to promote replication …

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    Publish Year:2015
  25. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/gene/2177

    FANCD2 FA complementation group D2 [ (human)] - National …

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    Fancd2 and Fanci
    Fanconi Anemia
  26. Nature
    https://www.nature.com/articles/s41594-022-00820-9

    The DNA-damage kinase ATR activates the FANCD2-FANCI …

    Tags:
    Fancd2 Antibody
    Fancd2 Gene
  27. GeneCards
    https://www.genecards.org/cgi-bin/carddisp.pl?gene=FANCD2

    FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody

    Tags:
    Fanconi Anemia
    Fancd2 Antibody
    Fancd2 Gene in Ovarian Cancer
    Fancd2 Ub
  28. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270283

    Clinical Validation of the Somatic FANCD2 Mutation (c.2022 …