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- This pathway is responsible for the repair of DNA interstrand cross-links (ICL) and the maintenance of genomic stability in response to replication stress. At the center of the pathway is the monoubiquitination of two FA proteins, FANCD2 and FANCI, on two specific lysine residues.Author: Kimon Lemonidis, Connor Arkinson, Martin L. Rennie, Helen WaldenPublish Year: 2021
pubmed.ncbi.nlm.nih.gov/34137174/ FANCD2–FANCI surveys DNA and recognizes double- to single …
Jul 31, 2024 · The FANCD2–FANCI (D2–I) protein complex is central to this process as it initiates repair by coordinating DNA incisions around the lesion 1. However, D2–I is also known to have a more general role in DNA repair and in protecting stalled replication forks from unscheduled …
Fanconi anemia protein FANCI functions in ribosome biogenesis
One such protein in the FA pathway is FANCI (14 – 16), mutated in 1% of FA patients (5). FANCI and its binding partner, FANCD2, together are called the ID complex and are activated for …
- Studies of fancd2 fanci function
Mechanism, specificity, and function of FANCD2-FANCI
This pathway is responsible for the repair of DNA interstrand cross-links (ICL) and the maintenance of genomic stability in response to replication stress. At the center of the pathway …
FANCD2–FANCI is a clamp stabilized on DNA by
Feb 17, 2020 · FANCD2–FANCI adopts a closed conformation when the FANCD2 subunit is monoubiquitinated, creating a channel that encloses double-stranded DNA (dsDNA). Ubiquitin is positioned at the interface of FANCD2 and FANCI, …
The DNA-damage kinase ATR activates the FANCD2-FANCI …
Sep 1, 2022 · DNA interstrand cross-links are tumor-inducing lesions that block DNA replication and transcription. When cross-links are detected at stalled replication forks, ATR kinase …
FANCI and FANCD2 have common as well as independent …
Nov 11, 2017 · Our findings indicate that FANCD2 fulfills crucial roles in mediating cellular resistance to HU or APH independent of FANCI. In fact, HU- or APH-triggered cell death in …
Fanconi anemia protein FANCI functions in ribosome …
Jan 28, 2019 · One such protein in the FA pathway is FANCI (14 – 16), mutated in 1% of FA patients (5). FANCI and its binding partner, FANCD2, together are called the ID complex and are activated for DNA repair by phosphorylation …
FANCD2-FANCI surveys DNA and recognizes double- to single …
The FANCD2-FANCI (D2-I) protein complex is central to this process as it initiates repair by coordinating DNA incisions around the lesion 1. However, D2-I is also known to have a more …
Differential functions of FANCI and FANCD2 ubiquitination
Jul 3, 2020 · The Fanconi anaemia (FA) pathway is a dedicated pathway for the repair of DNA interstrand crosslinks and is additionally activated in response to other forms of replication …
Differential functions of FANCI and FANCD2 ubiquitination …
Jul 7, 2020 · The Fanconi anaemia (FA) pathway is a dedicated pathway for the repair of DNA interstrand crosslinks and is additionally activated in response to other forms of replication …
Identification of the Fanconi anemia (FANC) I protein, a ...
Several FA proteins form a ubiquitin ligase that controls monoubiquitination of the FANCD2 protein in an ATR-dependent manner. Here we describe a new FA protein FANCI, identified as …
FANCI and FANCD2 have common as well as independent …
Oct 20, 2017 · Our findings indicate that FANCD2 fulfills crucial roles in mediating cellular resistance to HU or APH independent of FANCI. In fact, HU- or APH-triggered cell death in …
The Fanconi anaemia pathway: new players and new functions
May 5, 2016 · Fanconi anaemia proteins have other functions in addition to ICL repair. Fanconi anaemia proteins, notably FANCD2, have crucial roles in replication fork protection and …
DNA repair protein FANCD2 has both ubiquitination-dependent …
Mar 1, 2023 · When DNA interstrand crosslink lesions occur, a core complex of Fanconi anemia proteins promotes the ubiquitination of FANCD2 and FANCI, which recruit downstream factors …
FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody
Oct 2, 2024 · This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with …
The FANCI/FANCD2 complex links DNA damage response to R …
Jan 23, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair and …
Differential functions of FANCI and FANCD2 ... - EMBO reports
Jun 8, 2020 · The Fanconi anaemia (FA) pathway is a dedicated pathway for the repair of DNA interstrand crosslinks and is additionally activated in response to other forms of replication …
FANCD2 Binds MCM Proteins and Controls Replisome Function …
Sep 12, 2013 · Here, we identified FANCD2 and FANCI in a proteomic screen of replisome-associated factors bound to nascent DNA in response to replication arrest. We found that …
FANCI and FANCD2 have common as well as independent …
Nov 16, 2017 · FANCD2 also functions during the replication stress response by mediating the restart of temporarily stalled replication forks thereby suppressing the firing of new replication …
Model of common and independent functions of FANCD2 and …
(A) FANCD2 and FANCI act in concert during the cellular response to DNA ICLs in S-phase to promote ICL removal and cell survival. (B and C) FANCD2 and FANCI have separate roles …
PP2A licenses the FANCD2/FANCI complex for chromosome …
The Fanconi anemia (FA) pathway removes interstrand crosslinks (ICLs) between the Watson-Crick strands of the DNA double helix in humans. Central to the pathway is the …
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