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FANCD2 | Wikipedia
Fanconi anemia is a disorder with a recessive Mendelian pattern of inheritance characterized by chromosomal instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not … See more
Tobacco smoke suppresses the expression of FANCD2, which codes for a DNA damage "caretaker" or repair mechanism. See more
• Hejna JA, Timmers CD, Reifsteck C, Bruun DA, Lucas LW, Jakobs PM, et al. (May 2000). "Localization of the Fanconi anemia … See more
Humans with a FANCD deficiency display hypogonadism, male infertility, impaired spermatogenesis, and reduced female fertility. Similarly, mice deficient in FANCD2 show hypogonadism, impaired fertility and impaired gametogenesis.
In the non-mutant … See moreFANCD2 has been shown to interact with:
• FANCI
• Ataxia telangiectasia mutated,
• See moreWikipedia text under CC-BY-SA license FANCD2–FANCI is a clamp stabilized on DNA by
WEBFeb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that …
- Author: Pablo Alcón, Shabih Shakeel, Zhuo A. Chen, Juri Rappsilber, Juri Rappsilber, Ketan J. Patel, Lori A....
- Publish Year: 2020
FANCD2–FANCI surveys DNA and recognizes double- to single …
WEBJul 31, 2024 · The FANCD2–FANCI (D2–I) protein complex is central to this process as it initiates repair by coordinating DNA incisions around the lesion 1. However, D2–I is also …
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The Fanconi Anemia/BRCA Pathway: FANCD2 at the …
WEBAvailable data indicate that FANCD2 is involved in cell cycle regulation and DNA repair. Our current knowledge on the functional significance of FA …
- Author: Massimo Bogliolo, Jordi Surrallés
- Published: 2013
- Publish Year: 2013
FANCD2 modulates the mitochondrial stress response to prevent …
WEBJan 29, 2021 · We show that FANCD2, a master regulator of CFS stability, dampens the activation of the mitochondrial stress response and prevents mitochondrial dysfunction.
- Author: Philippe Fernandes, Benoit Miotto, Claude Saint-Ruf, Maha Said, Viviana Barra, Viviana Barra, Viola ...
- Publish Year: 2021
FANCD2 and DNA Damage - PMC | National Center for …
WEBAug 19, 2017 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, …
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Mechanism, specificity, and function of FANCD2-FANCI ... | PubMed
WEBRecent work suggests that FANCD2 ubiquitination transforms the ID2 complex into a sliding DNA clamp. Further ubiquitination on FANCI does not alter this closed-on-DNA ID2 …
Differential functions of FANCI and FANCD2
WEBJun 8, 2020 · Our above results demonstrate separate functions for the two monoubiquitination events occurring on the ID2 complex. FANCD2 ubiquitination was found to modulate ID2‐dsDNA binding affinity, …
FANCD2 and DNA Damage | PubMed
WEBAug 19, 2017 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, …
The FANCI/FANCD2 complex links DNA damage response to R …
WEBJan 23, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair …
The DNA-damage kinase ATR activates the FANCD2-FANCI …
WEBSep 1, 2022 · Monoubiquitinated FANCD2–FANCI is locked onto DNA and recruits nucleases that mediate DNA repair. However, it remains unclear how phosphorylation …
Structure of the FANCI-FANCD2 Complex: Insights into the
WEBJul 15, 2011 · Fanconi anemia is a cancer predisposition syndrome caused by defects in the repair of DNA interstrand cross-links (ICLs). Central to this pathway is the Fanconi …
FANCD2 Binds CtIP and Regulates DNA-End Resection during …
WEBMay 22, 2014 · A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand crosslinks (ICLs), where it coordinates DNA …
FANCI and FANCD2 have common as well as independent …
WEBOct 20, 2017 · We suggest at least two possible explanations: (i) FANCI actively opposes FANCD2 to negatively regulate HDR or (ii) FANCD2 and FANCI work in concert during …
FANCD2 FA complementation group D2 [ (human)] | National …
WEBThis gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci …
The key to the FANCD2–FANCI lock | Nature
WEBSep 7, 2022 · New cryo-EM structures of the FANCD2–FANCI complex provide insights into how phosphorylation of FANCI facilitates DNA clamping to prime the complex for …
FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand …
WEBJul 29, 2010 · The mono-ubiquitylated ID complex locates to sites of DNA damage to which it recruits FAN1, a mono-ubiquitin–binding protein. FAN1 has a DNA …
FANCD2 maintains replication fork stability during ... | Nature
WEBMay 27, 2022 · In agreement with a role of FANCD2 during replication fork restart , 5hmdC exposure also increased the frequency of collapsed forks in Fancd2 −/− cells compared …
Expression of FANCD2 is associated with prognosis in patients …
WEBSep 1, 2019 · FANCD2 was significantly higher in T 1-2, stage I-II NPC tissues with a disease duration shorter than 6 months than in T 3-4, stage III-IV NPC tissues with a …
FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody
WEBAug 6, 2024 · FANCD2 (FA Complementation Group D2) is a Protein Coding gene. Diseases associated with FANCD2 include Fanconi Anemia, Complementation Group …
Fancd2 in vivo interaction network reveals a non-canonical role in ...
WEBApr 5, 2017 · Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 …
Fanconi anemia proteins participate in a break-induced ... | Nature
WEBJun 10, 2021 · The FA core complex, which comprises eight FA proteins (FANCA/B/C/E/F/G/L/M) and additional associated subunits, monoubiquitinates the …
FANCD2 promotes mitotic rescue from transcription-mediated
WEBDec 21, 2022 · These fragile loci are targeted by the Fanconi anemia protein, FANCD2, to facilitate the resolution of under-replicated DNA, thus preventing chromosome mis …
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