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See all on WikipediaFANCD2 - Wikipedia
In the non-mutant mouse, FANCD2 is expressed in spermatogonia, pre-leptotene spermatocytes, and in spermatocytes in the leptotene, zygotene and early pachytene stages of meiosis. [18] . In synaptonemal complexes of meiotic chromosomes, activated FANCD2 protein co-localizes with BRCA1 (breast … See more
Fanconi anemia is a disorder with a recessive Mendelian pattern of inheritance characterized by chromosomal instability, hypersensitivity to DNA … See more
Humans with a FANCD deficiency display hypogonadism, male infertility, impaired spermatogenesis, and reduced female fertility. Similarly, mice … See more
Tobacco smoke suppresses the expression of FANCD2, which codes for a DNA damage "caretaker" or repair mechanism.
Cancer
FANCD2 mutant mice have a significantly increased … See moreFANCD2 has been shown to interact with:
• FANCI
• Ataxia telangiectasia mutated,
• BARD1, See more• Hejna JA, Timmers CD, Reifsteck C, Bruun DA, Lucas LW, Jakobs PM, et al. (May 2000). "Localization of the Fanconi anemia complementation group D gene to a 200-kb region on chromosome 3p25.3". American Journal of Human Genetics. 66 (5): 1540–51. See more
Wikipedia text under CC-BY-SA license FANCD2 Gene - GeneCards | FACD2 Protein
Oct 2, 2024 · FANCD2 (FA Complementation Group D2) is a Protein Coding gene. Diseases associated with FANCD2 include Fanconi Anemia, Complementation Group D2 and Fanconi Anemia, Complementation Group A. …
FANCD2 - My Cancer Genome
FANCD2 is an inclusion criterion in 27 clinical trials for malignant solid tumor, of which 22 are open and 5 are closed. Of the trials that contain FANCD2 status and malignant solid tumor as …
FANCD2 facilitates replication through common fragile sites
Oct 10, 2016 · We propose that FANCD2 has a multifaceted role in facilitating replication at difficult to replicate genomic regions such as CFS. It helps the replication machinery navigate …
FANCD2–FANCI surveys DNA and recognizes double- to single …
Jul 31, 2024 · DNA crosslinks block DNA replication and are repaired by the Fanconi anaemia pathway. The FANCD2–FANCI (D2–I) protein complex is central to this process as it initiates …
Entry - *613984 - FANCD2 GENE; FANCD2 - OMIM
Aug 10, 2020 · HGNC Approved Gene Symbol: FANCD2. Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38) : 3:10,026,437-10,101,932 (from NCBI)
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FANCD2 protein expression summary - The Human Protein Atlas
Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas. All transcripts of all genes have been analyzed regarding the location (s) of …
Expression of FANCD2 is associated with prognosis in patients …
Sep 1, 2019 · The FANCD2 gene is located on chromosome 3p25.3 and consists of 44 exons and encodes 2 proteins that both contain 1451 amino acids (FANCD2-S and FANCD2-L). These 2 …
The Fanconi anaemia pathway: new players and new functions
May 5, 2016 · What are the timings and locations of ubiquitylation and deubiquitylation of FANCD2? What do FANCD2 foci represent? Is FANCD2 monoubiquitylated in those foci, and …
FANCD2–FANCI is a clamp stabilized on DNA by
Feb 17, 2020 · Ubiquitin is positioned at the interface of FANCD2 and FANCI, where it acts as a covalent molecular pin to trap the complex on DNA. In contrast, isolated FANCD2 is a homodimer that is unable to...
The identification of FANCD2 DNA binding domains reveals …
Aug 8, 2017 · FANCD2 was shown to activate the transcription of tumor suppressor Tap63 by binding to its promoter . The DNA binding domain we identified binds to DNA without …
The identification of FANCD2 DNA binding domains reveals
Aug 21, 2017 · By using synthetic peptide mapping and DNA binding screen by electromobility shift assays, we found that FANCD2 bears two major DNA binding domains predominantly …
DNA repair protein FANCD2 has both ubiquitination-dependent …
Mar 1, 2023 · When DNA interstrand crosslink lesions occur, a core complex of Fanconi anemia proteins promotes the ubiquitination of FANCD2 and FANCI, which recruit downstream factors …
The DNA-damage kinase ATR activates the FANCD2-FANCI …
Sep 1, 2022 · Monoubiquitinated FANCD2–FANCI is locked onto DNA and recruits nucleases that mediate DNA repair. However, it remains unclear how phosphorylation activates this pathway. …
Differential functions of FANCI and FANCD2 ... - EMBO reports
Jun 8, 2020 · Our above results demonstrate separate functions for the two monoubiquitination events occurring on the ID2 complex. FANCD2 ubiquitination was found to modulate …
FANCD2 and REV1 cooperate in the protection of nascent DNA …
Sep 9, 2015 · We found that REV1 is targeted to laser-induced DNA damage stripes in a manner dependent on its ubiquitin-binding motifs, on RAD18, and on monoubiquitinated FANCD2 …
Subcellular localization of FANCD2 is associated with survival in ...
Feb 25, 2020 · Expression of the Fanconi Anemia complementation group D2 protein (FANCD2) is reduced in ovarian surface epithelial cells (OSE) in patients with ovarian cancer. FANCD2 …
type FANCD2 (Figure 1(b)), which has not been described previously. Surprisingly, while H 2O 2 was a potent inducer of FANCD2 foci in cells with a functional FA pathway (Figure 2(a)), …
FANCD2 modulates the mitochondrial stress response to prevent …
Jan 29, 2021 · We propose that FANCD2 coordinates nuclear and mitochondrial activities to prevent genome instability. Common fragile sites (CFSs) are genomic regions that are prone …
The FANCI/FANCD2 complex links DNA damage response to R …
Jan 23, 2024 · We propose a model wherein SRSF1 and FANCD2 interaction links DNA damage response to the avoidance of pathogenic R-loops via regulation of mRNA export.
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