fancd2 loci - Search
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  1. Nature
    https://www.nature.com/articles/s42003-022-04360-2

    FANCD2 promotes mitotic rescue from transcription-mediated

    • Replication stress (RS) is a leading cause of genome instability and cancer development. A substantial source of endogenous RS originates from the encounter between the transcription and replicati… See more

    Introduction

    DNA replication is an essential process that must be tightly regulated and completed ahead of chromosome segregation to maintain genome stability and sustain cell proliferation.… See more

    Nature
    Results

    SETX prevents spontaneous chromosome fragility marked by recruitment of … See more

    Nature
    Discussion

    DNA replication and transcription are two vital cellular processes that, when occurring concomitantly, must be tightly regulated to prevent transcription-mediated RS and DNA dama… See more

    Nature
    Methods

    Cell line, culture conditions and treatments
    Human colon cancer cell line, HCT116 (American Type Culture Collection), was maintained in McCoy’s 5A medium (Thermo Fi… See more

    Nature
    Data availability

    Unprocessed blot images are shown in Supplementary Fig. 6. Source data underlying the graphs are available in Supplementary Data 1. All other relevant data are av… See more

    Nature
    Acknowledgements

    The authors are grateful to the members of UMR9019 Genome Integrity and Cancers for useful discussions and advice, and to E. Di Tommaso (S. Giunta lab, Department of Biology & B… See more

    Nature
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    Table of Contents
    Introduction
    Results
    Discussion
    Methods
    Data availability
    Acknowledgements
     

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  2. Studies of fancd2 loci
    National Center for Biotechnology Information
    FANCD2 facilitates replication through common fragile sites
    Nearly two-thirds of the human genome is comprised of repetitive sequences that often challenge DNA replication, which can lead to genomic instability. CFSs are chromosomal regions that are most prone to genomic instability and are implicated in the development and progression of cancer (Arlt et al....
    Author: Advaitha Madir…
    Published: 2016/10/10
    DOI: 10.1016/j.molcel.2…
    National Center for Biotechnology Information
    FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells
    DNA replication is an essential process that must be tightly regulated and completed ahead of chromosome segregation to maintain genome stability and sustain cell proliferation. However, the cell is often faced with circumstances that challenge genome duplication due to stalling of replication fo...
    Author: Maha Said, Vi…
    Published: 2022
    Publication: Commun …
    National Center for Biotechnology Information
    Fanconi Anemia Protein FANCD2 Promotes Immunoglobulin Gene Conversion and DNA Repair through a Mechanism Related to Homologous Recombination†
    Recent studies show overlap between Fanconi anemia (FA) proteins and those involved in DNA repair mediated by homologous recombination (HR). However, the mechanism by which FA proteins affect HR is unclear. FA proteins (FancA/C/E/F/G/L) form a multiprotein complex, which is responsible for DNA damag...
    Author: Kazuhiko Yam…
    Published: 2005/01
    Publication: Mol Cell B…
    ScienceDirect
    Review Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA
    Biallelic mutations of FANCD2 and other components of the Fanconi Anemia (FA) pathway cause a disease characterized by bone marrow failure, cancer predisposition and a striking sensitivity to agents that induce crosslinks between the two complementary DNA strands (inter-strand crosslinks-ICL). Such ...
    Published: 2018/03/01
    Cited By: 0
    Keywords: A-EJ altern…
     
  3. Nature
    https://www.nature.com/articles/s42003-021-01647-8

    FANCD2 modulates the mitochondrial stress response to prevent …

     
  4. Nature
    https://www.nature.com/articles/ncb1882

    Replication stress induces sister-chromatid bridging at …

    May 24, 2009 · Here we show that the Fanconi anaemia proteins FANCD2 and FANCI specifically associate with common fragile site loci irrespective of whether the chromosome is broken.

  5. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC4951507

    Cellular response to DNA interstrand crosslinks: the Fanconi …

  6. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683400

    FANCD2 facilitates replication through common fragile sites

  7. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S1097276516305664

    FANCD2 Facilitates Replication through Common Fragile Sites

  8. People also ask
    What does FANCD2 do?
    Cell Biol. 11, 753–760 (2009). Fernandes, P. et al. FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability. Commun. Biol. 4, 127 (2021). Madireddy, A. et al. FANCD2 facilitates replication through common fragile sites. Mol. Cell 64, 388–404 (2016).

    FANCD2 promotes mitotic rescue from transcription-mediated ... - Nature

    nature.com
    What is FANCD2–FANCI?
    FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular mechanism that reconciles the roles of FANCD2–FANCI in the recognition and protection of stalled replication forks.

    FANCD2–FANCI surveys DNA and recognizes double- to single ... - Nat…

    nature.com
    Where are FANCD2 sister foci located?
    Notably, all of the FANCD2/I sister foci were located on chromosome arms in normal fibroblasts, and not at centromeres. These data indicate that FANCD2 sister foci are established during S phase and persist into mitosis.

    Replication stress induces sister-chromatid bridging at fragile

    nature.com
    How are FANCD2 and FANCI detected?
    The presence of both FANCD2 and FANCI were confirmed through the detection of both green (FANCD2-Cy3) and red (FANCI-Cy5; shown as magenta in the figures) fluorophores within the same particle (Fig. 1c).

    FANCD2–FANCI surveys DNA and recognizes double- to single ... - Nat…

    nature.com
    What is the function of FANCD2–FANCI complex in Fanconi anaemia?
    DNA interstrand crosslinks (ICLs) are toxic lesions that block DNA replication and transcription, and are detected and repaired by the Fanconi anaemia pathway. The FANCD2–FANCI (D2–I) complex is key to Fanconi anaemia DNA repair as it binds dsDNA and is required for recruitment of nucleases that excise crosslinks 1.

    FANCD2–FANCI surveys DNA and recognizes double- to single ... - Nat…

    nature.com
    How does FANCD2 bind to CFS loci in mitosis?
    FANCD2 specifically localizes to CFS loci 27, 28 that remain incompletely replicated in mitosis 24, 29, in a manner dependent on transcription and mitochondrial stress 30, where it facilitates their replication and limits the formation of R-loops through a yet unidentified mechanism 31, likely by interacting with RNA processing factors 32.

    FANCD2 promotes mitotic rescue from transcription-mediated ... - Nature

    nature.com
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  9. Springer
    https://link.springer.com/article/10.1007/s10142-024-01453-5

    FANCD2 genome binding is nonrandom and is enriched at large …

  10. Cell Press
    https://www.cell.com/molecular-cell/fulltext…

    FANCD2 Facilitates Replication through Common …

    By visualizing the in vivo replication dynamics of individual DNA fibers, we found a striking change in the replication program at the CFS loci in FANCD2 −/− patient-derived lymphoblasts. We propose that FANCD2 has a multifaceted role in …

  11. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC5381226

    Fancd2 in vivo interaction network reveals a non-canonical role in ...

  12. Cell Press
    https://www.cell.com/molecular-cell/pdf/S1097-2765(16)30566-4.pdf
    [PDF]

    FANCD2 Facilitates Replication through Common Fragile …

  13. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S2211124723015358

    FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ...

  14. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772326

    FANCD2 promotes mitotic rescue from transcription-mediated …

  15. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538764

    Fanconi Anemia Protein FANCD2 Promotes Immunoglobulin …

  16. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC8384067

    FANCD2-Associated Nuclease 1 Partially Compensates for the …

  17. Nature
    https://www.nature.com/articles/s41586-024-07770-w

    FANCD2–FANCI surveys DNA and recognizes double- to single …

  18. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0027510717301148

    Beyond interstrand crosslinks repair: contribution of FANCD2 and …

  19. Cell Press
    https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01622-4

    The FANCI/FANCD2 complex links DNA damage response to R …

  20. Nature
    https://www.nature.com/articles/s41467-024-51090-6

    The Fanconi anemia core complex promotes CtIP-dependent end …

  21. GeneCards
    https://www.genecards.org/cgi-bin/carddisp.pl?gene=FANCD2

    FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody

  22. Nature
    https://www.nature.com/articles/s41594-022-00826-3

    The key to the FANCD2–FANCI lock - Nature

  24. Some results have been removed