fancd2 loci - Search
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  1. Nature
    https://www.nature.com/articles/s42003-022-04360-2

    FANCD2 promotes mitotic rescue from transcription-mediated

    • Replication stress (RS) is a leading cause of genome instability and cancer development. A substantial source of endogenous RS originates from the encounter between the transcription and replicati… See more

    Introduction

    DNA replication is an essential process that must be tightly regulated and completed ahead of chromosome segregation to maintain genome stability and sustain cell proliferation.… See more

    Nature
    Results

    SETX prevents spontaneous chromosome fragility marked by recruitment of … See more

    Nature
    Discussion

    DNA replication and transcription are two vital cellular processes that, when occurring concomitantly, must be tightly regulated to prevent transcription-mediated RS and DNA dama… See more

    Nature
    Methods

    Cell line, culture conditions and treatments
    Human colon cancer cell line, HCT116 (American Type Culture Collection), was maintained in McCoy’s 5A medium (Thermo Fi… See more

    Nature
    Data availability

    Unprocessed blot images are shown in Supplementary Fig. 6. Source data underlying the graphs are available in Supplementary Data 1. All other relevant data are av… See more

    Nature
    Acknowledgements

    The authors are grateful to the members of UMR9019 Genome Integrity and Cancers for useful discussions and advice, and to E. Di Tommaso (S. Giunta lab, Department of Biology & B… See more

    Nature
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    Table of Contents
    Introduction
    Results
    Discussion
    Methods
    Data availability
    Acknowledgements
     

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  2. Studies of fancd2 loci
    National Center for Biotechnology Information
    FANCD2 facilitates replication through common fragile sites
    Nearly two-thirds of the human genome is comprised of repetitive sequences that often challenge DNA replication, which can lead to genomic instability. CFSs are chromosomal regions that are most prone to genomic instability and are implicated in the development and progression of cancer (Arlt et al....
    Author: Advaitha Madir…
    Published: 2016/10/10
    DOI: 10.1016/j.molcel.2…
    National Center for Biotechnology Information
    FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability
    Common fragile sites (CFSs) are genomic regions that are prone to form breaks and gaps within metaphase chromosomes in response to replication stress1. CFSs are known to drive genomic instability from the earliest steps of tumor development2,3. CFS instability is cell-type dependent and is influence...
    Author: Philippe Ferna…
    Published: 2021
    Publication: Commun …
    National Center for Biotechnology Information
    FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells
    DNA replication is an essential process that must be tightly regulated and completed ahead of chromosome segregation to maintain genome stability and sustain cell proliferation. However, the cell is often faced with circumstances that challenge genome duplication due to stalling of replication fo...
    Author: Maha Said, Vi…
    Published: 2022
    Publication: Commun …
    National Center for Biotechnology Information
    Fanconi Anemia Protein FANCD2 Promotes Immunoglobulin Gene Conversion and DNA Repair through a Mechanism Related to Homologous Recombination†
    Recent studies show overlap between Fanconi anemia (FA) proteins and those involved in DNA repair mediated by homologous recombination (HR). However, the mechanism by which FA proteins affect HR is unclear. FA proteins (FancA/C/E/F/G/L) form a multiprotein complex, which is responsible for DNA damag...
    Author: Kazuhiko Yam…
    Published: 2005/01
    Publication: Mol Cell B…
    ScienceDirect
    Review Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA
    Biallelic mutations of FANCD2 and other components of the Fanconi Anemia (FA) pathway cause a disease characterized by bone marrow failure, cancer predisposition and a striking sensitivity to agents that induce crosslinks between the two complementary DNA strands (inter-strand crosslinks-ICL). Such ...
    Published: 2018/03/01
    Cited By: 0
    Keywords: A-EJ altern…
     
  3. Nature
    https://www.nature.com/articles/s42003-021-01647-8

    FANCD2 modulates the mitochondrial stress response to prevent …

     
  4. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683400

    FANCD2 facilitates replication through common fragile sites

  5. Nature
    https://www.nature.com/articles/ncb1882

    Replication stress induces sister-chromatid bridging at …

    May 24, 2009 · Here we show that the Fanconi anaemia proteins FANCD2 and FANCI specifically associate with common fragile site loci irrespective of whether the chromosome is broken.

  6. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC4951507

    Cellular response to DNA interstrand crosslinks: the Fanconi …

  7. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S1097276516305664

    FANCD2 Facilitates Replication through Common Fragile Sites

  8. Springer
    https://link.springer.com/article/10.1007/s10142-024-01453-5

    FANCD2 genome binding is nonrandom and is enriched at large …

  9. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC5381226

    Fancd2 in vivo interaction network reveals a non-canonical role in ...

  10. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846573

    FANCD2 modulates the mitochondrial stress response to prevent …

  11. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC8384067

    FANCD2-Associated Nuclease 1 Partially Compensates for the …

  12. Cell Press
    https://www.cell.com/molecular-cell/fulltext…

    FANCD2 Facilitates Replication through Common …

    By visualizing the in vivo replication dynamics of individual DNA fibers, we found a striking change in the replication program at the CFS loci in FANCD2−/− patient-derived lymphoblasts. We propose that FANCD2 has a multifaceted role in …

  13. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772326

    FANCD2 promotes mitotic rescue from transcription-mediated …

  14. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S2211124723015358

    FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ...

  15. Cell Press
    https://www.cell.com/molecular-cell/pdf/S1097-2765(16)30566-4.pdf
    [PDF]

    FANCD2 Facilitates Replication through Common Fragile …

  16. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538764

    Fanconi Anemia Protein FANCD2 Promotes Immunoglobulin …

  17. Nature
    https://www.nature.com/articles/s41586-024-07770-w

    FANCD2–FANCI surveys DNA and recognizes double- to single …

  18. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0027510717301148

    Beyond interstrand crosslinks repair: contribution of FANCD2 and …

  19. Nature
    https://www.nature.com/articles/s41594-022-00826-3

    The key to the FANCD2–FANCI lock - Nature

  20. GeneCards
    https://www.genecards.org/cgi-bin/carddisp.pl?gene=FANCD2

    FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody

  21. Nature
    https://www.nature.com/articles/s41467-024-51090-6

    The Fanconi anemia core complex promotes CtIP-dependent end …

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