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The Fanconi anaemia pathway: new players and new functions
May 5, 2016 · The Fanconi anaemia pathway comprises 19 Fanconi anaemia proteins (FANCA to FANCT) and many associated proteins. Germline inactivation of any of the Fanconi anaemia …
- Author: Raphael Ceccaldi, Prabha Sarangi, Alan D. D'Andrea
- Publish Year: 2016
The Fanconi Anemia/BRCA Pathway: FANCD2 at the …
Available data indicate that FANCD2 is involved in cell cycle regulation and DNA repair. Our current knowledge on the functional significance of FA pathway …
- Author: Massimo Bogliolo, Jordi Surrallés
- Published: 2013
- Publish Year: 2013
- Studies of fancd2 pathway
The Fanconi Anemia DNA Repair Pathway
Fanconi anemia (FA) is caused by faulty DNA repair of interstrand crosslinks (ICLs) in every cell in patients with the disease. Researchers have discovered 23 genes to date that cause FA …
Fanconi anemia pathway: Current Biology - Cell Press
Sep 25, 2017 · FANCD2, for example, prevents the accumulation of single-stranded DNA and pathological replication intermediaries, binds nascent DNA and restrains the replication fork.
FANCD2–FANCI surveys DNA and recognizes double- to single …
Jul 31, 2024 · DNA crosslinks block DNA replication and are repaired by the Fanconi anaemia pathway. The FANCD2–FANCI (D2–I) protein complex is central to this process as it initiates …
Structure of the FANCI-FANCD2 Complex: Insights into the …
Jul 7, 2011 · Fanconi Anemia is a cancer predisposition syndrome caused by defects in the repair of DNA interstrand crosslinks (ICL). Central to this pathway is the FANCI-FANCD2 (ID) …
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Stress and DNA repair biology of the Fanconi anemia pathway
Oct 30, 2014 · Establishing the interaction network involving the FA proteins and their associated partners has revealed an intersection of FA with several DNA repair pathways, including …
Histone H2AX and Fanconi anemia FANCD2 function in the …
Mar 3, 2007 · The FANCD2 gene is a key player in the FA pathway (reviewed in Bogliolo and Surrallés, 2005 ). Together with FANCL and FANCM/Hef, it is the only FA gene present in non …
The Fanconi anemia (FA) pathway confers glioma resistance to …
Jan 13, 2007 · a Simplified model of the Fanconi anemia (FA) DNA repair pathway. Mono-ubiquitination (Ub) of FANCD2 is carried out by the FANC-A, B, C, E, F, G, L, and M …
The FANCI/FANCD2 complex links DNA damage …
Jan 23, 2024 · We show that binding of SRSF1 to FANCD2 stimulates FANCD2 monoubiquitination, which is crucial for the licensing of signaling and DNA repair events in the FA pathway in an RNA-dependent manner. We provide evidence …
FANCD2 modulates the mitochondrial stress response to prevent …
Jan 29, 2021 · FANCD2, a key component of the FANC pathway, has been shown to relocalize to large genes encompassing CFSs after replication stress 22,23 and form foci at CFSs during …
The Fanconi anemia pathway induces chromothripsis …
Aug 23, 2024 · Inactivation of the FA pathway suppresses chromosome shattering during mitosis without impacting interphase-associated defects within micronuclei. Mono-ubiquitination of FANCI-FANCD2 by the FA core complex …
Chk1-Mediated Phosphorylation of FANCE Is Required for the …
Feb 12, 2007 · The eleven Fanconi anemia (FA) proteins cooperate in a novel pathway required for the repair of DNA cross-links. Eight of the FA proteins (A, B, C, E, F, G, L, and M) form a …
The Fanconi Anemia Pathway Promotes Replication-Dependent …
Nov 12, 2009 · A central event in the activation of the Fanconi anemia pathway is the mono-ubiquitylation of the FANCI-FANCD2 complex, but how this complex confers ICL resistance …
Fanconi anemia proteins participate in a break-induced ... - Nature
Jun 10, 2021 · These results demonstrate that FANCD2 promotes the cleavage-coupled BIR pathway but not the cleavage-free pathway. FANCD2 recruits downstream endonucleases for …
Regulation of FANCD2 by the mTOR pathway contributes to the …
These data suggest that the mTOR pathway may promote the repair of DNA double strand breaks by sustaining FANCD2 and provide a novel mechanism of how the FA pathway modulates DNA damage response and repair.
Histone H2AX and Fanconi anemia FANCD2 function in the …
The central FA protein FANCD2 is known to relocate to chromatin upon DNA damage in a poorly understood process. Here, we have induced subnuclear accumulation of DNA damage to …
FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody
Oct 2, 2024 · FANCD2 (FA Complementation Group D2) is a Protein Coding gene. Diseases associated with FANCD2 include Fanconi Anemia, Complementation Group D2 and Fanconi …
FANCD2–FANCI is a clamp stabilized on DNA by ... - Nature
Feb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that may recruit other DNA repair factors.
FANCD2 facilitates replication through common fragile sites
Oct 10, 2016 · FANCD2 deficiency is associated with altered replication initiation and instability at CFS loci (A) Cytogenetic FISH analysis using the IGH/MAF probe set, to detect and compare breaks at CFS-FRA16D in lymphoblasts and fibroblasts, in …
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