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FANCD2 - Wikipedia
Fanconi anemia group D2 protein is a protein that in humans is encoded by the FANCD2 gene. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2 (this gene), FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, … See more
Fanconi anemia is a disorder with a recessive Mendelian pattern of inheritance characterized by chromosomal instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective See more
Tobacco smoke suppresses the expression of FANCD2, which codes for a DNA damage "caretaker" or repair mechanism. See more
• Hejna JA, Timmers CD, Reifsteck C, Bruun DA, Lucas LW, Jakobs PM, et al. (May 2000). "Localization of the Fanconi anemia … See more
Humans with a FANCD deficiency display hypogonadism, male infertility, impaired spermatogenesis, and reduced female fertility. Similarly, mice deficient in FANCD2 show hypogonadism, impaired fertility and impaired gametogenesis.
In the non-mutant … See moreFANCD2 has been shown to interact with:
• FANCI
• Ataxia telangiectasia mutated,
• See moreWikipedia text under CC-BY-SA license FANCD2OS - Wikipedia
Fanconi Anemia Opposite Strand Transcript protein is a predicted protein that in humans is encoded by the FANCD2OS gene. The name is derived from mRNA transcribed from the strand complementary to the FANCD2 gene.
Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 2 mins
FANCA - Wikipedia
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- Studies of fancd2 wikipedia
FANCD2 Gene - GeneCards | FACD2 Protein | FACD2 Antibody
WEBAug 6, 2024 · FANCD2 (FA Complementation Group D2) is a Protein Coding gene. Diseases associated with FANCD2 include Fanconi Anemia, Complementation Group …
FANCD2 modulates the mitochondrial stress response to prevent …
WEBJan 29, 2021 · We show that FANCD2, a master regulator of CFS stability, dampens the activation of the mitochondrial stress response and prevents mitochondrial dysfunction.
FANCD2 and DNA Damage - PMC - National Center for …
WEBAug 19, 2017 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, …
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Differential functions of FANCI and FANCD2
WEBJun 8, 2020 · A key step in the FA pathway is the monoubiquitination of each of the two subunits (FANCI and FANCD2) of the ID2 complex on specific lysine residues. However, the molecular function of these …
FANCD2–FANCI is a clamp stabilized on DNA by
WEBFeb 17, 2020 · Together, our work suggests that FANCD2–FANCI is a clamp that is locked onto DNA by ubiquitin, with distinct interfaces that may recruit other DNA repair factors.
FANCD2–FANCI surveys DNA and recognizes double- to single …
WEBJul 31, 2024 · FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular mechanism …
FANCD2 FA complementation group D2 [ (human)] - National …
WEBThis gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci …
Mechanism, specificity, and function of FANCD2-FANCI
WEBAt the center of the pathway is the monoubiquitination of two FA proteins, FANCD2 and FANCI, on two specific lysine residues. This is achieved by the combined action of the …
FANCE - Wikipedia
WEBSome characteristics of FANCE are that it can set itself up with ubiquitinated FANCD2, BRCA2 and constructed nuclear foci. Also, as it is the only member showing direct union …
Mechanism, specificity, and function of …
WEBJun 17, 2021 · Fanconi anemia (FA) is a rare genetic disorder caused by mutations in any of the currently 22 known FA genes. The products of these genes, along with other FA-associated proteins, participate in a ...
Ferroptosis regulator FANCD2 is associated with immune …
WEBOct 4, 2022 · FANCD2 is an essential gene involved in DNA damage repair and ferroptosis inhibition. FANCD2 has been found to induce transcription-dependent and …
The FANCI/FANCD2 complex links DNA damage response to R …
WEBJan 23, 2024 · The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair …
FANCD2 and DNA Damage - PubMed
WEBAug 19, 2017 · Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, …
FBXL12 degrades FANCD2 to regulate replication recovery and …
WEBAug 16, 2023 · Fanconi anemia (FA) signaling, a key genomic maintenance pathway, is activated in response to replication stress. Here, we report that phosphorylation of the …
FANCI - Wikipedia
WEBFANCI monoubiquitination is essential for repairing DNA interstrand crosslinks, and clamps the protein on DNA together with its partner protein FANCD2. The …
FANCD2 maintains replication fork stability during ... - Nature
WEBMay 27, 2022 · Fanconi anemia (FA) is a rare hereditary disorder caused by mutations in any one of the FANC genes. FA cells are mainly characterized by extreme …
FANCB - Wikipedia
WEBFanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased …
Fancd2 in vivo interaction network reveals a non-canonical role in ...
WEBApr 5, 2017 · Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 …
FANCI and FANCD2 have common as well as independent …
WEBOct 20, 2017 · Fanconi anemia (FA) is an inherited cancer predisposition syndrome characterized by cellular hypersensitivity to DNA interstrand crosslinks (ICLs).
The DNA-damage kinase ATR activates the FANCD2-FANCI …
WEBSep 1, 2022 · Monoubiquitinated FANCD2–FANCI is locked onto DNA and recruits nucleases that mediate DNA repair. However, it remains unclear how phosphorylation …
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