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Nov 8, 2022 · We reveal that the first mitotic division has an extended prometaphase/metaphase and exhibits phenotypes that can cause nondisjunction. These included multipolar …

Nov 29, 2024 · By examining the first mitotic divisions of human embryos using live cell imaging, three recent studies identify spindle architecture and positioning features that could provide …

Jul 29, 2024 · To delineate the spatiotemporal organization of the first mitotic division typical for normal human embryo development, we systematically analyzed a unique timelapse dataset …

Apr 7, 2023 · A very recent study based on an oocyte-share-to-research programme investigated the fine details of the first event of chromosome segregation in the human embryo, revealing a …

Jul 28, 2020 · Applying this workflow to the first mitotic division (1- to 2-cell stage) of a population of human embryos revealed that the length of the first mitotic division was approximately 3 …

Jul 17, 2020 · Here, using cell-permeable DNA dyes, we film chromosome segregation during the first and second mitotic cleavage divisions in human embryos from women undergoing …

Jul 17, 2020 · We propose that the first mitotic division in humans is a unique and highly error-prone event, which contributes to fetal aneuploidies. Human reproduction requires the …

We reveal that the first mitotic division has an extended prometaphase/metaphase and exhibits phenotypes that can cause nondisjunction. These included multipolar chromosome …

Jun 1, 2023 · The meiotic spindle is replaced by a segregation machinery that may form as a transient or persistent dual mitotic spindle. Maternal proteins assist the decay of maternal …

Jun 25, 2024 · We observe that the first mitotic spindles vary, and low-aspect-ratio-shaped spindles tend to lead to the formation of multiple nuclei at the 2-cell stage. Moreover, we …

Feb 20, 2017 · In this study, the subcellular localization and possible roles of H3S10ph were evaluated in the first mitotic cell cycle progression of porcine embryos using western blot, …

Jan 30, 2025 · The mitotic phase is a multistep process during which the duplicated chromosomes are aligned, separated, and move into two new, identical daughter cells. The first portion of the …

Mitosis is a type of cell division where cells divide to produce new cells.. Mitosis is the process that takes place when: an organism grows. an organism becomes damaged and needs to …

Here we combine non-invasive time-lapse imaging with karyotypic reconstruction of all blastomeres in four-cell human embryos to address the hypothesis that blastomere behaviour …

2 days ago · Greatwall, a conserved MAST-like kinase with crucial mitotic entry functions, is curiously absent in worms. Here, the single canonical MAST kinase family member KIN-4 is …

Zygotes are an elegant model because factors can be depleted in the oocyte prior to the first mitotic division; in addition, zygotes reveal vital functions required in early embryos. Fifty DSBs …

Dec 4, 2012 · Here we combine non-invasive time-lapse imaging with karyotypic reconstruction of all blastomeres in four-cell human embryos to address the hypothesis that blastomere …

A very recent study based on an oocyte-share-to-research programme investigated the fine details of the first event of chromosome segregation in the human embryo, revealing a highly …

6 days ago · In contrast, somatic cells complete their growth through mitosis alone. The development of germ cells is a delicate and prolonged process. In most mammals, a complete …

14 hours ago · Inhibition of Plk1 results in mitotic arrest and aberrant cell division ... as organoids or mammalian embryos allowing to understand how ... from mitotic entry (first frame after …