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  1. Role of glutamine synthetase in angiogenesis beyond glutamine …

    • Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows negligible glutamine-synthesi… See more

    Main

    Endothelial cells (ECs) line the lumen of blood vessels. Emerging evidence reveals that EC metabolism controls vessel sprouting (angiogenesis)1,2,3. Although glutamineSee more

    Nature
    Vessel sprouting requires endothelial GS

    We checked the expression of GS in endothelial cells of the retinal microvasculature with a genetic Glul reporter mouse (Glul+/GFP mice with a nucleus-tar… See more

    Nature
    Silencing GLUL reduces EC migration

    We then used GLUL knockdown (GLULKD) HUVECs (mediated by short hairpin RNA (shRNA); >80% silencing; Extended Data Fig. 2a) in in vitro spheroid-sprouting assays to a… See more

    Nature
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  3. Glutamine Synthetase: Localization Dictates Outcome - PMC

     
  4. Structural Analysis of Glutamine Synthetase from - Nature

  5. Differences in regulation mechanisms of glutamine synthetases …

  6. Exploring the Catalytic Mechanism of Human Glutamine …

  7. Evidence for glutamine synthetase function in mouse spinal cord ...

  8. Glutamine synthetase structure‐catalysis …

    Nov 22, 2018 · Glutamine synthetase is a key enzyme that exists in every living organism. It is responsible for incorporating ammonium into glutamate, generating glutamine. Research on this enzyme has grown substantially over the last …

  9. Glutamine Synthetase as a Therapeutic Target for Cancer …

  10. Advances in the functional study of glutamine synthetase in plant ...

  11. Glutamine Synthetase as a Therapeutic Target for Cancer …

  12. Glutamine reliance in cell metabolism | Experimental ... - Nature

  13. Molecular Mechanisms of Glutamine Synthetase Mutations that …

  14. The Role of Glutamine Synthetase in Regulating Ammonium …

  15. M. mazei glutamine synthetase and glutamine synthetase-GlnK1 …

  16. Research paper NMDA receptor-mediated modulation on …

  17. Glutamine synthetase - Wikipedia

  18. Macrophage-derived glutamine boosts satellite cells and muscle …