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- Central to maintaining a healthy epithelium are intestinal stem cells (ISCs), which are essential for replenishing the intestinal epithelium throughout an individual’s lifespan. Recent research has unveiled the intricate interplay between ISCs and their niche, which includes various cell types, extracellular components, and signaling molecules.
www.nature.com/articles/s12276-024-01179-1 - People also askQ&A: Guthealthmicrosoftstart.msn.com
WebMar 1, 2024 · Central to maintaining a healthy epithelium are intestinal stem cells (ISCs), which are essential for replenishing the intestinal epithelium throughout an individual’s lifespan. Recent...
See results only from nature.comRoles of intestinal epitheli…
Open access. Published: 26 May 2017. Roles of intestinal epithelial cells in the …
Adult intestinal stem cells: cr…
Published: 11 December 2013. Adult intestinal stem cells: critical drivers of …
Intestinal stem cells - Latest …
Claudin-7 is essential for the maintenance of colonic stem cell homoeostasis via …
A growth factor-free culture …
42 Citations. 3 Altmetric. Metrics. Abstract. Lgr5 + intestinal stem cells (ISCs) drive …
WebAug 8, 2022 · Intestinal stem cells (ISCs) play an important role in maintaining intestinal homeostasis via promoting a healthy gut barrier. Within the stem cell niche, gut …
- DOI: 10.7150/ijbs.72600
- Published: 2022
- Publication: Int J Biol Sci. 2022; 18(13): 5185-5206.
WebIn response to diverse stress stimuli from a variety of external and internal cues, constant intestinal epithelial adaptation is required. The intestinal …
- Author: Gizem Calibasi-Kocal, Gizem Calibasi-Kocal, Omid Mashinchian, Yasemin Basbinar, Ender Ellidokuz, Chi...
- Publish Year: 2021
WebJan 18, 2019 · In addition to the actively cycling ISCs that maintain daily homeostasis, accumulating evidence supports the existence of other pools of stem/progenitor cells …
WebGenetic and pharmacologic evidence indicates a pivotal role of canonical Wnt signaling during intestinal homeostasis and Lgr5 + ISC proliferation with crypt/villus/Lgr5 + ISC loss observed upon diverse manipulations …
- Studies of gut stem cell maintenance
WebOpen access. Published: 26 May 2017. Roles of intestinal epithelial cells in the maintenance of gut homeostasis. Ryu Okumura & Kiyoshi Takeda. Experimental & …
WebCentral to maintaining a healthy epithelium are intestinal stem cells (ISCs), which are essential for replenishing the intestinal epithelium throughout an individuals...
WebNov 1, 2021 · Crypt-villus axes are important structures for massively enhancing the surface area of the gut for efficient absorption, but which need to be tightly regulated to ensure …
WebSep 16, 2016 · Here we review the current models of stem cell‐driven intestinal epithelial regeneration, with particular emphasis on human models; discuss how advancements in …
WebMar 8, 2022 · The midgut is maintained by pluripotent intestinal stem cells (ISCs) that self-renew and transiently differentiate into non-dividing enteroblasts (EBs) and pre-enteroendocrines (pre-EEs), which terminally …
Gut microbiota‐stem cell niche crosstalk: A new …
WebSep 27, 2022 · Open Access. Gut microbiota-stem cell niche crosstalk: A new territory for maintaining intestinal homeostasis. Ning Ma, Xiyue Chen, Lee J. Johnston, Xi Ma. First published: 27 September 2022. …
Regulation of Drosophila intestinal stem cell maintenance and ...
WebDec 17, 2014 · Abstract. Tissue stem cells divide to self-renew and generate differentiated cells to maintain homeostasis. Although influenced by both intrinsic and extrinsic factors, …
Muscarinic receptor M3 contributes to intestinal stem cell …
WebJul 9, 2021 · The ability of intestinal stem cells (ISCs) to divide and differentiate is necessary for tissue repair and homeostasis. Maintenance of a functional intestine …
Adult intestinal stem cells: critical drivers of epithelial ... - Nature
WebPublished: 11 December 2013. Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nick Barker. Nature Reviews Molecular Cell Biology 15 , …
Regulation of Drosophila intestinal stem cell maintenance and ...
WebNov 28, 2014 · Introduction. During homeostasis, tissue stem cells maintain the stem cell population through self‐renewal and give rise to differentiating progeny to replace …
Stem Cell Signaling Pathways in the Small Intestine - PMC
WebMar 16, 2020 · The ability of stem cells to divide and differentiate is necessary for tissue repair and homeostasis. Appropriate spatial and temporal mechanisms are needed. …
Autocrine and paracrine unpaired signaling regulate intestinal …
WebDec 15, 2012 · The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway is involved in the regulation of intestinal stem cell (ISC) activity to …
IDDF2021-ABS-0074 Gut microbial metabolite of tryptophan …
WebThe mitochondrial OXPHOS ability of intestinal crypt stem cells in CRS mice and control mice was assessed using Seahorse mitochondrial stress test. 16S rRNA analysis was …
Identifying the initial steps in colorectal cancer formation
Web1 day ago · Research led by Weill Cornell Medicine provides new evidence that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer …
Intestinal stem cells - Latest research and news | Nature
WebApr 27, 2024 · Claudin-7 is essential for the maintenance of colonic stem cell homoeostasis via the modulation of Wnt/Notch signalling. Kun Wang. Yin Liu. Lei Ding. Research Open …
Intestinal stem cell dynamics in homeostasis and cancer
WebFeb 10, 2022 · Uncovering stem cell dynamics in homeostasis and following acquisition of oncogenic mutations has provided unprecedented insights into CRC initiation, and it is …
Stem Cells in Repair of Gastrointestinal Epithelia - PMC
WebJun 14, 2017 · Each unit can be subdivided into a villus, protruding into the gut lumen and containing differentiated cells responsible for digestion and absorption, and crypt of …
Impact of microbiota specific circulating memory T cells in …
Web3 days ago · 2572 Background: The gut microbiota influences the cancer immune set point and response to immune checkpoint inhibitors (ICB), participating in the differentiation …
Gut bacteria boost immune response to fight tumors
WebMay 20, 2024 · Microbes also can leak out of the gut and trigger an immune response in the tumor or activate gut T cells that migrate to the tumor to mount an attack, Colonna …
Modulation of stem cell fate in intestinal homeostasis, injury and ...
WebMay 5, 2023 · Go to: Abstract. The mammalian intestinal epithelium constitutes the largest barrier against the external environment and makes flexible responses to various types …
Antagonizing vasoactive intestinal peptide (VIP) receptors with …
Web3 days ago · Vasoactive intestinal peptide (VIP) is an emerging checkpoint pathway for T cell function, which expresses VIP receptors (VIPR) and is abundantly expressed by …
A growth factor-free culture system underscores the coordination ...
WebSep 4, 2018 · 42 Citations. 3 Altmetric. Metrics. Abstract. Lgr5 + intestinal stem cells (ISCs) drive the fast renewal of intestinal epithelium. Several signaling pathways have been …
GFI1B specifies developmental potential of innate lymphoid cell
Web14 hours ago · Intestinal cells were isolasted as previously described (63, 64). Cells were blocked with PBS containing anti-CD16/CD32 (5 μg/ml; 2.4G2) and stained for 20 to 30 …
Gut microbiome remodeling and metabolomic profile improves in …
WebMay 24, 2024 · IL-13 may be important for gut mucosal immune responses and is a stimulator of mucus production from goblet cells 37, which has been recently reported to …
The histone demethylase Kdm6b regulates the maturation and …
WebJan 9, 2022 · Lysed target cells were analyzed by flow cytometry and gated as CFSE + 7-AAD + cells. Intestinal microbiota analysis ... McCoy KD. Regionalized Development …
Author Correction: c-Maf-dependent Treg cell control of intestinal …
WebMay 23, 2024 · Author Correction: c-Maf-dependent T reg cell control of intestinal T H 17 cells and IgA establishes host–microbiota homeostasis. Christian Neumann 1,2, Jonas …
Mechanisms of axonal support by oligodendrocyte-derived
WebMay 31, 2023 · As well as providing myelin sheaths for saltatory nerve conduction, oligodendrocytes support axonal maintenance and energy homeostasis via exosome …
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