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  1. Hill equation (biochemistry) - Wikipedia

    • In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration. A ligand is "a substance that forms a complex with a biomolecule to serve a biological purpose" (ligand definition), and a macromolecule is a very large molecule, such … See more

    Proportion of ligand-bound receptors

    The Hill equation is commonly expressed in the following ways.
    ,
    where:
    • … See more

    Tissue response

    A distinction should be made between quantification of drugs binding to receptors and drugs producing responses. There may not necessarily be a linear relationship between the two values. In contrast to this article's pre… See more

    Hill coefficient

    The Hill coefficient is a measure of ultrasensitivity (i.e. how steep is the response curve).
    The Hill coefficient, or , may describe cooperativity (or possibly other biochemical properties, … See more

    Reversible form

    The most common form of the Hill equation is its irreversible form. However, when building computational models a reversible form is often required in order to model product inhibition. For this reason, Hofmeyr and Cornis… See more

    Applications

    The Hill equation is used extensively in pharmacology to quantify the functional parameters of a drug and are also used in other areas of biochemistry.
    The Hill equation can be used to describe dose-respo… See more

    Limitations

    Because of its assumption that ligand molecules bind to a receptor simultaneously, the Hill equation has been criticized as a physically unrealistic model. Moreover, the Hill coefficient should not be considered … See more

     
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  2. In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration.
    Learn more:
    In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration.
    en.wikipedia.org/wiki/Hill_equation_(biochemistry)
    The Hill Equation, developed by Archibald Hill, describes cooperative ligand binding in allosteric proteins, particularly hemoglobin. It allows for the analysis of protein-ligand interactions by transforming the fractional saturation equation into a linear form, facilitating data interpretation.
    www.pearson.com/channels/biochemistry/learn/jas…
    The Hill equation is a mathematical representation that describes the fraction of a biomolecule that is bound to a ligand as a function of the ligand concentration.
    library.fiveable.me/key-terms/biological-chemistry-i/…
    The Hill equation describes the binding of a ligand to a macromolecule is often enhanced if there are already other ligands present on the same macromolecule. The hill coefficient provides a way to quantify this effect.
    www.vcalc.com/wiki/hill-equation
    The Hill equation (as a relationship between the concentration of a compound adsorbing to binding sites and the fractional occupancy of the binding sites) is equivalent to the Langmuir equation.
    reaction-networks.net/wiki/Hill_kinetics
     
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  4. C3. Mathematical Analysis of Cooperative Binding

    A plot of log (Y/1-Y) vs log L is called a Hill plot, where n is the Hill coefficient. This equation is of the form: y = mx + b which is a straight line with slope n and y intercept of - log Kd.

  5. Hill Equation - Interactive Graph - PhysiologyWeb

    Oct 22, 2014 · The interactive graph provided below allows for a good understanding of the Hill equation, how the reaction velocity changes as a function of the substrate concentration, and how changes in V max, K 0.5, and …

  6. Hill Equation - SpringerLink

  7. Hill equation - vCalc

  8. The Hill analysis and co-ion–driven transporter …

    Here, we review the use of the Hill equation, which is commonly used to analyze binding or kinetic data, to analyze the kinetics of ion-coupled transporters and show how the mechanism of transport affects the Hill coefficient.

  9. Hill kinetics - Mathematics of Reaction Networks

  10. The Hill equation revisited: uses and misuses - PubMed

  11. Hill Equation - (Biological Chemistry I) - Vocab, Definition

  12. Hill Equation - Online Tutor, Practice Problems & Exam Prep

  13. Beyond the hill equation: Reconceptualizing cooperativity for ...

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  16. 9.3.1: Binding Energy and Mass Defect - Chemistry LibreTexts

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