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  1. Hill equation (biochemistry) - Wikipedia

    • In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration. A ligand is "a substance that forms a complex with a biomolecule to serve a biological purpose" (ligand definition), and a macromolecule is a very large molecule, such … See more

    Proportion of ligand-bound receptors

    The Hill equation is commonly expressed in the following ways.
    ,
    where:
    • … See more

    Tissue response

    A distinction should be made between quantification of drugs binding to receptors and drugs producing responses. There may not necessarily be a linear relationship between the two values. In contrast to this article's pre… See more

    Hill coefficient

    The Hill coefficient is a measure of ultrasensitivity (i.e. how steep is the response curve).
    The Hill coefficient, or , may describe cooperativity (or possibly other biochemical properties, … See more

    Reversible form

    The most common form of the Hill equation is its irreversible form. However, when building computational models a reversible form is often required in order to model product inhibition. For this reason, Hofmeyr and Cornis… See more

    Applications

    The Hill equation is used extensively in pharmacology to quantify the functional parameters of a drug and are also used in other areas of biochemistry.
    The Hill equation can be used to describe dose-respo… See more

    Limitations

    Because of its assumption that ligand molecules bind to a receptor simultaneously, the Hill equation has been criticized as a physically unrealistic model. Moreover, the Hill coefficient should not be considered … See more

     
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    Binding of ligands to macromolecules
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    The Hill equation is used in biochemistry and pharmacology to describe the binding of ligands to macromolecules, particularly in the context of cooperative ligand binding in allosteric proteins like hemoglobin 1 2. It allows for the analysis of protein-ligand interactions by transforming the fractional saturation equation into a linear form 2.

     
  3. Hill Equation - Interactive Graph - PhysiologyWeb

    Oct 22, 2014 · The interactive graph provided below allows for a good understanding of the Hill equation, how the reaction velocity changes as a function of the substrate concentration, and how changes in V max, K 0.5, and …

     
  4. Hill equation (biochemistry) - WikiMili, The Best …

    Oct 5, 2024 · In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration.

  5. The Hill equation: a review of its capabilities in pharmacological ...

  6. C3. Mathematical Analysis of Cooperative Binding

    A plot of log (Y/1-Y) vs log L is called a Hill plot, where n is the Hill coefficient. This equation is of the form: y = mx + b which is a straight line with slope n and y intercept of - log Kd.

  7. Hill Equation - Online Tutor, Practice Problems

    The Hill Equation, developed by Archibald Hill, describes cooperative ligand binding in allosteric proteins, particularly hemoglobin. It allows for the analysis of protein-ligand interactions by transforming the fractional saturation equation …

  8. Hill Equation - SpringerLink

  9. Hill Equation - (Biological Chemistry I) - Vocab, Definition

  10. Hill equation (biochemistry) - Alchetron, the free social …

    Sep 30, 2024 · The Hill equation, which was originally formulated by Archibald Hill in 1910 to describe the sigmoidal O 2 binding curve of haemoglobin, is used to describe the fraction of a macromolecule saturated by ligand as a function of …

  11. Hill Equation - Vocab, Definition, and Must Know Facts - Fiveable

  12. Hill equation (biochemistry) - Wikiwand

  13. Hill Coefficient - an overview | ScienceDirect Topics

  14. Hill Equation | Channels for Pearson+

  15. Tietz textbook of clinical chemistry and molecular diagnostics

  16. Clinical Chemistry: Theory, Analysis, Correlation ... - Oxford …

  17. Fluid, Electrolyte, and Acid-Base Balance - ScienceDirect

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