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  1. Hill equation (biochemistry) - Wikipedia

    • In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration. A ligand is "a substance that forms a complex with a biomolecule to serve a biological purpose" (ligand definition), and a macromolecule is a very large molecule, such … See more

    Proportion of ligand-bound receptors

    The Hill equation is commonly expressed in the following ways.
    ,
    where:
    • … See more

    Tissue response

    A distinction should be made between quantification of drugs binding to receptors and drugs producing responses. There may not necessarily be a linear relationship between the two values. In contrast to this article's pre… See more

    Hill coefficient

    The Hill coefficient is a measure of ultrasensitivity (i.e. how steep is the response curve).
    The Hill coefficient, or , may describe cooperativity (or possibly other biochemical properties, … See more

    Reversible form

    The most common form of the Hill equation is its irreversible form. However, when building computational models a reversible form is often required in order to model product inhibition. For this reason, Hofmeyr and Cornis… See more

    Applications

    The Hill equation is used extensively in pharmacology to quantify the functional parameters of a drug and are also used in other areas of biochemistry.
    The Hill equation can be used to describe dose-respo… See more

    Limitations

    Because of its assumption that ligand molecules bind to a receptor simultaneously, the Hill equation has been criticized as a physically unrealistic model. Moreover, the Hill coefficient should not be considered … See more

     
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    The Hill equation is a mathematical representation used in biochemistry and pharmacology to describe the binding of ligands to macromolecules 1 2 3. It allows for the analysis of protein-ligand interactions, particularly in allosteric proteins like hemoglobin 3.

     
  3. Hill Equation - Interactive Graph - PhysiologyWeb

    Oct 22, 2014 · The Hill equation (see below) is commonly used to study the kinetics of reactions that exhibit a sigmoidal behavior. The rate of many enzyme-catalyzed reactions and many transporter-mediated processes can be …

     
  4. Hill equation (biochemistry) - WikiMili, The Best …

    Oct 5, 2024 · In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration.

  5. The Hill equation: a review of its capabilities in pharmacological ...

  6. Hill Equation - SpringerLink

  7. The Hill analysis and co-ion–driven transporter …

    Here, we review the use of the Hill equation, which is commonly used to analyze binding or kinetic data, to analyze the kinetics of ion-coupled transporters and show how the mechanism of transport affects the Hill coefficient.

  8. Hill kinetics - Mathematics of Reaction Networks

  9. Hill Equation - (Biological Chemistry I) - Vocab, Definition

  10. Hill Equation - Online Tutor, Practice Problems & Exam Prep

  11. Hill Equation - Vocab, Definition, and Must Know Facts - Fiveable

  12. Hill equation (biochemistry) - Wikiwand

  13. C3. Mathematical Analysis of Cooperative Binding - Hill Plot

  14. Hill Equation | Channels for Pearson+

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  16. Department of Biochemistry and Molecular Biophysics – …

  17. Hill reaction - Wikipedia

  18. Alumni of University of Tennessee-Health Science Center …

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