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- In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration.Learn more:In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration.en.wikipedia.org/wiki/Hill_equation_(biochemistry)The Hill equation is a mathematical formula used to describe the binding of ligands to macromolecules, such as proteins, and their subsequent interactions. It provides insight into cooperative binding phenomena, where the binding of one ligand affects the binding of additional ligands.library.fiveable.me/key-terms/biophysics/hill-equationThe Hill equation helps explain allosteric regulation by quantifying how the binding of one ligand to a protein influences the affinity for subsequent ligands. By analyzing the Hill coefficient (n), we can determine whether there is positive or negative cooperativity among subunits in a protein.library.fiveable.me/key-terms/biological-chemistry-i/…The Hill equation, which was originally formulated by Archibald Hill in 1910 to describe the sigmoidal O 2 binding curve of haemoglobin, is used to describe the fraction of a macromolecule saturated by ligand as a function of the ligand concentration.alchetron.com/Hill-equation-%28biochemistry%29Here, we review the use of the Hill equation, which is commonly used to analyze binding or kinetic data, to analyze the kinetics of ion-coupled transporters and show how the mechanism of transport affects the Hill coefficient.pmc.ncbi.nlm.nih.gov/articles/PMC4442790/
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Hill equation (biochemistry) - Wikipedia
In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration. A ligand is "a substance that forms a complex with a biomolecule to serve a biological purpose" (ligand definition), and … See more
The Hill equation is commonly expressed in the following ways.
,
where: See moreThe Hill coefficient is a measure of ultrasensitivity (i.e. how steep is the response curve).
The Hill coefficient, $${\displaystyle n}$$ or See moreThe Hill equation is used extensively in pharmacology to quantify the functional parameters of a drug and are also used in other areas of … See more
A distinction should be made between quantification of drugs binding to receptors and drugs producing responses. There may not necessarily … See more
The most common form of the Hill equation is its irreversible form. However, when building computational models a reversible form is … See more
Because of its assumption that ligand molecules bind to a receptor simultaneously, the Hill equation has been criticized as a physically unrealistic model. Moreover, the Hill coefficient should not be considered a reliable approximation of the number of … See more
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The Hill analysis and co-ion–driven transporter …
Here, we review the use of the Hill equation, which is commonly used to analyze binding or kinetic data, to analyze the kinetics of ion-coupled transporters and show how the mechanism of transport affects the Hill coefficient.
Hill coefficients, dose–response curves and allosteric …
Hill coefficients (nH) derived from four parameter logistic fits to dose–response curves were compared to calculated realistic reaction schemes and related to experimental data: (1) Hill coefficients may give information on the number of …
Hill Equation - (Biophysics) - Vocab, Definition, Explanations
Hill Equation - (Biological Chemistry I) - Vocab, Definition
C3. Mathematical Analysis of Cooperative Binding
A plot of log (Y/1-Y) vs log L is called a Hill plot, where n is the Hill coefficient. This equation is of the form: y = mx + b which is a straight line with slope n and y intercept of - log Kd.
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